2018
DOI: 10.1002/med.21547
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Therapeutic strategies involving survivin inhibition in cancer

Abstract: Survivin is a small protein that belongs to the inhibitor of apoptosis protein family. It is abundantly expressed in tumors compared with adult differentiated tissues, being associated with poor prognosis in many human neoplasms. This apoptotic inhibitor has a relevant role in both the promotion of cancer cell survival and in the inhibition of cell death. Consequently, aberrant survivin expression stimulates tumor progression and confers resistance to several therapeutic strategies in a variety of tumors. In f… Show more

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Cited by 118 publications
(83 citation statements)
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References 120 publications
(167 reference statements)
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“…Furthermore, survivin, a member of the Inhibitors of Apoptosis (IAP) family, was enriched in EVs secreted from different tumor types [177][178][179]. This protein has been implicated in suppressing cell death and promoting mitosis [180]. Indeed, treating highly aggressive MDA-MB-231 breast cancer cells with Paclitaxel promoted the secretion of EVs enriched with survivin that significantly contributed to the survival of serum-starved and Paclitaxel-treated fibroblasts and SKBR3 breast cancer cells [181].…”
Section: Exosomal Drug Resistancementioning
confidence: 99%
“…Furthermore, survivin, a member of the Inhibitors of Apoptosis (IAP) family, was enriched in EVs secreted from different tumor types [177][178][179]. This protein has been implicated in suppressing cell death and promoting mitosis [180]. Indeed, treating highly aggressive MDA-MB-231 breast cancer cells with Paclitaxel promoted the secretion of EVs enriched with survivin that significantly contributed to the survival of serum-starved and Paclitaxel-treated fibroblasts and SKBR3 breast cancer cells [181].…”
Section: Exosomal Drug Resistancementioning
confidence: 99%
“…Moreover, the NLR (Nod‐like receptor) signalling pathway, apoptosis and regulation of autophagy pathways were top‐ranked pathways enriched by GSEA analysis (Figure C). Several inflammation‐related genes, such as TNF, IL‐1β and NLRP3, were common among these enriched pathways …”
Section: Resultsmentioning
confidence: 99%
“…Importantly, the C-terminus of survivin is dispensable for cell division, whereas the N-terminus is required for apoptosis [29]. Moreover, a high level of survivin is related to enhanced angiogenesis, tumor invasion and metastasis, and chemo/radioresistance, and downregulation of survivin reversed these functions [25,30,31]. For example, overexpression of survivin confers insulin-like growth factor-induced lapatinib resistance in head and neck squamous carcinoma cells (HNSCC) [32].…”
Section: Discussionmentioning
confidence: 99%