Therapeutic strategies for aberrant splicing in cancer and genetic disorders
Wenhua Shi,
Jingqun Tang,
Juanjuan Xiang
Abstract:Accurate pre‐mRNA splicing is essential for proper protein translation; however, aberrant splicing is commonly observed in the context of cancer and genetic disorders. Notably, in genetic diseases, these splicing abnormalities often play a pivotal role. Substantial challenges persist in accurately identifying and classifying disease‐induced aberrant splicing, as well as in development of targeted therapeutic strategies. In this review, we examine prevalent forms of aberrant splicing and explore potential thera… Show more
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