Therapeutic role of inflammasome inhibitors in neurodegenerative disorders

Lahooti, Behnaz; Chhibber, Tanya; Bagchi, Sounak; Varahachalam, Sree Pooja; Jayant, Rahul Dev

doi:10.1016/j.bbi.2020.11.004

Cited by 29 publications

(29 citation statements)

References 175 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Finally, a formation of pores by the N-terminal gasdermin D at the plasma membrane induces pyroptosis and propagation of the inflammatory signal [117,124,126]. Thus, regarding their inflammatory action, NLRP inflammasomes are already implicated in different pathogeneses, as is the case more often in pathological pregnancies [127][128][129][130][131][132][133].…”

Section: Nlrp Inflammasome Activationmentioning

confidence: 99%

See 1 more Smart Citation

Pathophysiological Implication of Pattern Recognition Receptors in Fetal Membranes Rupture: RAGE and NLRP Inflammasome

et al. 2021

View full text Add to dashboard Cite

Preterm prelabor ruptures of fetal membranes (pPROM) are a pregnancy complication responsible for 30% of all preterm births. This pathology currently appears more as a consequence of early and uncontrolled process runaway activation, which is usually implicated in the physiologic rupture at term: inflammation. This phenomenon can be septic but also sterile. In this latter case, the inflammation depends on some specific molecules called “alarmins” or “damage-associated molecular patterns” (DAMPs) that are recognized by pattern recognition receptors (PRRs), leading to a microbial-free inflammatory response. Recent data clarify how this activation works and which receptor translates this inflammatory signaling into fetal membranes (FM) to manage a successful rupture after 37 weeks of gestation. In this context, this review focused on two PRRs: the receptor for advanced glycation end-products (RAGE) and the NLRP7 inflammasome.

show abstract

Section: Nlrp Inflammasome Activationmentioning

confidence: 99%

“…Thus, regarding their inflammatory action, NLRP inflammasomes are already implicated in different pathogeneses, as is the case more often in pathological pregnancies [ 127 , 128 , 129 , 130 , 131 , 132 , 133 ].…”

Section: Inflammasomesmentioning

confidence: 99%

Pathophysiological Implication of Pattern Recognition Receptors in Fetal Membranes Rupture: RAGE and NLRP Inflammasome

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Inflammasomes are one of the most crucial components of the innate immune system and play important roles in the pathogeneses of various inflammation‐related neurological diseases. 7 tPA was reported to promote inflammasome activation after ischemic stroke in hyperglycemic mice. 8 Inflammasome activation was shown to lead to BBB disruption, hemorrhagic transformation, and poor outcomes in hyperglycemic patients suffering from ischemic stroke.…”

Section: Introductionmentioning

confidence: 99%

AIM2 deletion enhances blood‐brain barrier integrity in experimental ischemic stroke

Bian

Shu

et al. 2021

CNS Neurosci Ther

View full text Add to dashboard Cite

show abstract

“…To date, nearly 10 inflammasomes have been described, including NLR family pyrin domin containing 1 (NLRP1), NLRP2, NLRP3, NLRP6, NLRC4, NLRP12, pyrin, absent in melanoma 2 (AIM2), and interferon gamma inducible protein 16 (IFI16). [ 2 , 13 , 15 , 16 , 18 , 21 ] However, the specific inflammasomes that are most strongly associated with stroke and how they are activated have remained unclear, which promoted us to review and analyze the corresponding literature in the present study.…”

Section: Introductionmentioning

confidence: 99%

Global trends and prospects about inflammasomes in stroke: a bibliometric analysis

et al. 2021

View full text Add to dashboard Cite

Background Sterile inflammation is a key pathological process in stroke. Inflammasome activation has been implicated in various inflammatory diseases, including ischemic stroke and hemorrhagic stroke. Hence, targeting inflammasomes is a promising approach for the treatment of stroke. Methods We applied bibliometric methods and techniques. The Web of Science Core Collection was searched for studies indexed from database inception to November 26, 2020. We generated various visual maps to display publications, authors, sources, countries, and keywords. Results Our literature search yielded 427 publications related to inflammasomes involved in stroke, most of which consisted of original research articles and reviews. In particular, we found that there was a substantial increase in the number of relevant publications in 2018. Furthermore, most of the publications with the highest citation rates were published in 2014. Relatively, the field about inflammasomes in stroke developed rapidly in 2014 and 2018. Many institutions contributed to these publications, including those from China, the United States, and worldwide. We found that NLR family pyrin domain containing 3 (NLRP3) was the most studied, followed by NLRP1, NLRP2, and NLRC4 among the inflammasomes associated with stroke. Analysis of keywords suggested that the most studied mechanisms involved dysregulation of extracellular pH, efflux of Ca2+ ions, dysfunction of K+/Na+ ATPases, mitochondrial dysfunction, and damage to mitochondrial DNA. Conclusions Given the potential diagnostic and therapeutic implications, the specific mechanisms of inflammasomes contributing to stroke warrant further investigation. We used bibliometric methods to objectively present the global trend of inflammasomes in stroke, and to provide important information for relevant researchers.

show abstract

Therapeutic role of inflammasome inhibitors in neurodegenerative disorders

Cited by 29 publications

References 175 publications

Pathophysiological Implication of Pattern Recognition Receptors in Fetal Membranes Rupture: RAGE and NLRP Inflammasome

Pathophysiological Implication of Pattern Recognition Receptors in Fetal Membranes Rupture: RAGE and NLRP Inflammasome

AIM2 deletion enhances blood‐brain barrier integrity in experimental ischemic stroke

Global trends and prospects about inflammasomes in stroke: a bibliometric analysis

Contact Info

Product

Resources

About