Therapeutic Resistance in Acute Myeloid Leukemia: The Role of Non-Coding RNAs

Zebisch, Armin; Hatzl, Stefan; Pichler, Martin; Wölfler, Albert; Sill, Heinz

doi:10.3390/ijms17122080

Cited by 59 publications

(51 citation statements)

References 101 publications

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“…Nrf2 is a pivotal regulator in antioxidative stress that can be activated by various phytochemicals or Chinese herbal medicine formula [26,27]. For example, Tao Hong Si Wu decoction (THSWD) and Z-ligustilide have been reported to activate PI3K/AKT and Nrf2/HO-1 signalling to protect against cerebral ischemia-reperfusion injury [28,29].…”

Section: Discussionmentioning

confidence: 99%

Scutellaria barbata D. Don (SBD) protects oxygen glucose deprivation/reperfusion-induced injuries of PC12 cells by up-regulating Nrf2

Wang

Li²,

Zhang³

2019

Artificial Cells, Nanomedicine, and Biotechnology

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This study aimed to investigate the potential effect of Scutellaria barbata D. Don (SBD) on oxygen glucose deprivation/reperfusion (OGD/R)-injured PC12 cells. PC12 cells were pretreated with various concentrations of 0.1-0.8 mg/ml SBD for indicated times (12-48 h) and then subjected to OGD/R injury. Cell viability, apoptosis and proliferation were detected using MTT assay, flow cytometry, Ki67 staining and western blot. Oxidative damage was assessed by detecting MDA content, SOD activity and GSH levels. The mitochondrial membrane potential (Dwm) was measured by Rh123 staining. Western blot was performed to assess the expression levels of Nrf2 and PI3K/AKT pathway-related proteins. We found that SBD pretreatment promoted cell viability and proliferation but inhibited apoptosis of OGD/R-injured PC12 cells in dosage-and time-dependent manner. Meanwhile, SBD attenuated oxidative damage and restored mitochondria dysfunction, as evidenced by the reduced MDA content, the increased SOD and GSH levels, and the increased Dwm. Furthermore, SBD induced the expression of Nrf2 in a PI3K/AKT-dependent signalling. Knockdown of Nrf2 blocked the protective effects of SBD on PC12 cells. In conclusion, this study demonstrates that SBD pretreatment protects PC12 cells against OGD/R-induced injury. The potential mechanism may be through up-regulating the expression of Nrf2 in a PI3K/AKT-dependent pathway. ARTICLE HISTORY

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Section: Discussionmentioning

confidence: 99%

Scutellaria barbata D. Don (SBD) protects oxygen glucose deprivation/reperfusion-induced injuries of PC12 cells by up-regulating Nrf2

Wang

Li²,

Zhang³

2019

Artificial Cells, Nanomedicine, and Biotechnology

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“…Non‐coding RNAs (ncRNAs) are RNA transcripts of variable length, which are basically not transcribed and translated into proteins. Two best studied examples, especially in cancer, are micro‐RNAs (miRNAs) and long non‐coding RNAs (lncRNAs) . The discovery of the miRNA and lncRNA families has created additional layers of genomic regulatory functions .…”

Section: Introductionmentioning

confidence: 99%

MALAT1 modulates the autophagy of retinoblastoma cell through miR‐124‐mediated stx17 regulation

Huang

Yang

Fang

et al. 2018

J of Cellular Biochemistry

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The retinoblastoma is the most common intraocular malignant tumor in infants and children; it is one of the deadliest forms of cancer due to its limited sensitivity to chemotherapy and radiotherapy. In several cancers, chemoresistance is associated with autophagy induction. Non-coding RNAs, including long non-coding RNAs (lncRNA) and microRNAs (miRNAs) have been reported to regulate physiological activities of the cells, including proliferation, apoptosis, migration, as well as autophagy. MALAT1, a well-established lncRNA acts as an oncogene, promotes cancer proliferation, and metastasis via the stimulation of autophagy. In addition to MALAT1, miR-124, a known tumor suppressor, has also been reported to regulate cell apoptosis and autophagy in dopaminergic neurons. In the present study, we investigated the roles of MALAT1 and miR-124 in the regulation of retinoblastoma cell autophagy through evaluating the changes of autophagy-related proteins. Through direct targeting miR-124, MALAT1 promotes retinoblastoma cell autophagy. Further, we investigated whether Syntaxin 17 (STX17), a Soluble NSF Attachment Protein receptor (SNARE) of the autophagosome, is involved in MALAT1/miR-124 regulation of retinoblastoma cell autophagy, and the underlying mechanism. Taken together, we provided novel experimental and theoretical basis for regulation of retinoblastoma cell autophagy, and potential direction of dealing with autophagy-induced chemoresistance of retinoblastoma, which need further in-depth study.

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“…Investigations of samples from cohort of patients of different ages, miRNA-181a was identified as marker of chemosensitivity [75,102]. The main function of this miRNA is activation of apoptotic activity in cells and inducing sensitivity of leukemic to native immunity action.…”

Section: Sncrnas As Markers Of Therapeutic Resistance or Sensitivity mentioning

confidence: 99%

Small Non-Coding RNAs in Regulation of Course and Therapeutic Efficacy in Acute Myeloid Leukemia

Klimenko¹

2018

Myeloid Leukemia

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Small non-coding RNAs (sncRNAs) are small regulatory molecules, which play key roles in fine-tune of all cell functions. In late 1970s and early 1980s, it was first determined that non-coding RNAs contribute to the cellular regulatory processes. The kingdom of sncRNAs is very numerous and it is clear that functions of different members of this family is different from each other and may be involved in normal and pathologic processes in cell. Recently it was investigated that sncRNAs and long non-coding RNAs play roles in cellular differentiation, proliferation, metabolic processes, bioenergetic regulation, cell death and inter-cellular communications, etc. In embryos, non-coding RNAs control maternal-zygotic transition, the maintenance of pluripotency, the pattering of the body axes, the specification and differentiation of cell types and morphogenesis of organs. Development of hematologic malignancies in humans, their course and regulation of resistance and sensitivity of tumorous cells to therapy are under the control of sncRNAs.

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Therapeutic Resistance in Acute Myeloid Leukemia: The Role of Non-Coding RNAs

Cited by 59 publications

References 101 publications

Scutellaria barbata D. Don (SBD) protects oxygen glucose deprivation/reperfusion-induced injuries of PC12 cells by up-regulating Nrf2

Scutellaria barbata D. Don (SBD) protects oxygen glucose deprivation/reperfusion-induced injuries of PC12 cells by up-regulating Nrf2

MALAT1 modulates the autophagy of retinoblastoma cell through miR‐124‐mediated stx17 regulation

Small Non-Coding RNAs in Regulation of Course and Therapeutic Efficacy in Acute Myeloid Leukemia

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