Therapeutic relevance of eosinophilic inflammation and airway viral interactions in severe asthma
Hitasha Rupani,
William W. Busse,
Peter H. Howarth
et al.
Abstract:The role of eosinophils in airway inflammation and asthma pathogenesis is well established, with raised eosinophil counts in blood and sputum associated with increased disease severity and risk of asthma exacerbation. Conversely, there is also preliminary evidence suggesting antiviral properties of eosinophils in the airways. These dual roles for eosinophils are particularly pertinent as respiratory virus infections contribute to asthma exacerbations. Biologic therapies targeting key molecules implicated in eo… Show more
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