Therapeutic proteins immunogenicity: a peptide point of view
Feliciana Real-Fernandez,
Fosca Errante,
Andrea Di Santo
et al.
Abstract:Protein therapeutics are extensively used in the treatment of autoimmune diseases, but a subset of patients appears to be refractory to these treatments, mainly due to the development of an immune response to the drug. A better understanding of the mechanism underlying the therapeutic drug’s failure becomes fundamental for the development of new and more effective treatments. Unfortunately, there are few cases where the exact mechanisms through which drugs bypass immunological tolerance and provoke immunogenic… Show more
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