Therapeutic prospects of microRNAs in cancer treatment through nanotechnology

Awasthi, Rajendra; Rathbone, Michael J.; Hansbro, Philip M.; Bebawy, Mary; Dua, Kamal

doi:10.1007/s13346-017-0440-1

Cited by 34 publications

(26 citation statements)

References 127 publications

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“…Previous studies have shown that the expression of miR‐373 is regulated by CREB in zinc transporter 4‐induced progression of pancreatic cancer (Awasthi et al , 2018). Since microRNAs elicit specific cellular effects (Esteller, 2011), we wanted to understand the role of miR‐373 in our experimental setup.…”

Section: Resultsmentioning

confidence: 99%

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Norepinephrine‐CREB1‐miR‐373 axis promotes progression of colon cancer

Han

Jiang

et al. 2020

Molecular Oncology

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The adrenergic system contributes to the stress-induced onset and progression of cancer. Adrenergic fibers are the primary source of norepinephrine (NE). The underlying mechanisms involved in NE-induced colon cancer remain to be understood. In this study, we describe the function and regulatory network of NE in the progression of colon cancer. We demonstrate that NE-induced phosphorylation of cAMP response element-binding protein 1 (CREB1) promotes proliferation, migration, and invasion of human colon cancer cells. The downstream effector of NE, CREB1, bound to the promoter of miR-373 and transcriptionally activated its expression. miR-373 expression was shown to be necessary for NE-induced cell proliferation, invasion, and tumor growth. We confirmed that proliferation and invasion of colon cancer cells are regulated in vitro and in vivo by miR-373 through targeting of the tumor suppressors TIMP2 and APC. Our data suggest that NE promotes colon cancer cell proliferation and metastasis by activating the CREB1-miR-373 axis. The study of this novel signaling axis may provide mechanistic insights into the neural regulation of colon cancer and help in the design of future clinical studies on stress biology in colorectal cancer.Abbreviations APC, adenomatous polyposis coli; CRC, colorectal cancer; CREB1, cAMP response element-binding protein 1; NE, norepinephrine; qRT-PCR, quantitative real-time polymerase chain reaction; TCGA, The Cancer Genome Atlas; TH, tyrosine hydroxylase; TIMP2, tissue inhibitor of metalloproteinases 2.

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Section: Resultsmentioning

confidence: 99%

“…MicroRNAs (miRs) are involved in the regulation of gene expression and may potentially serve as new therapeutics in cancer (Awasthi et al , 2018). miR‐373 plays a variety of roles in tumorigenesis and tumor progression.…”

Section: Introductionmentioning

confidence: 99%

Norepinephrine‐CREB1‐miR‐373 axis promotes progression of colon cancer

Han

Jiang

et al. 2020

Molecular Oncology

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“…Emerging research indicates that only certain types of encapsulated miRNA play a role in cell-cell signaling and others may not. Exosomes, for instance, appear to transport miRNA that promote paracrine communication [375][376][377] and nanotechnology can be used to deliver chemically modified miRNA to cancer cells [378,379].…”

Section: Discussionmentioning

confidence: 99%

The Multiple Roles of Hepatitis B Virus X Protein (HBx) Dysregulated MicroRNA in Hepatitis B Virus-Associated Hepatocellular Carcinoma (HBV-HCC) and Immune Pathways

Sartorius

Swadling

et al. 2020

Viruses

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Currently, the treatment of hepatitis B virus (HBV)-associated hepatocellular carcinoma (HCC) [HBV-HCC] relies on blunt tools that are unable to offer effective therapy for later stage pathogenesis. The potential of miRNA to treat HBV-HCC offer a more targeted approach to managing this lethal carcinoma; however, the complexity of miRNA as an ancillary regulator of the immune system remains poorly understood. This review examines the overlapping roles of HBx-dysregulated miRNA in HBV-HCC and immune pathways and seeks to demonstrate that specific miRNA response in immune cells is not independent of their expression in hepatocytes. This interplay between the two pathways may provide us with the possibility of using candidate miRNA to manipulate this interaction as a potential therapeutic option.

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“…Treatment of any cancer aims to remove or destroy the cancerous cells without killing normal cells. The most common traditional methods used for treatment include surgery, radiation, and chemotherapy which can be used either alone or in combination with each other [8] [24]. The most consistent and effective option to treat patients suffering from lung cancer is surgical resection.…”

Section: Traditional Methods and The Importance Of Nano-carriers In Tmentioning

confidence: 99%

Emerging trends in the novel drug delivery approaches for the treatment of lung cancer

Sharma

Mehta

Dhanjal

et al. 2019

Chemico-Biological Interactions

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338

149

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Cancer is one of the major diseases that cause a high number of deaths globally. Of the major types of cancers, lung cancer is known to be the most chronic form of cancer in the world. The conventional management of lung cancer includes different medical interventions like chemotherapy, surgical removal, and radiation therapy. However, this type of approach lacks specificity and also harms the adjacent normal cells. Lately, nanotechnology has emerged as a promising intervention in the management and treatment of lung cancers. Nanotechnology has revolutionized the existing modalities and focuses primarily on reducing toxicity and improving the bioavailability of anticancer drugs to the target tumor cells. Nanocarrier systems are being currently used extensively to exploit and to overcome the obstructions induced by cancers in the lungs. The nano-carrier-loaded therapeutic drug delivery methods have shown promising potential in treating lung cancer as its target is to control the growth of tumor cells. In this review, various modes of nano drug delivery options like liposomes, dendrimers, quantum dots, carbon nanotubes and metallic nanoparticles have been discussed. Nano-carrier drug delivery systems emerge as a promising approach and thus is expected to provide newer and advanced avenues in cancer therapeutics.

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Therapeutic prospects of microRNAs in cancer treatment through nanotechnology

Cited by 34 publications

References 127 publications

Norepinephrine‐CREB1‐miR‐373 axis promotes progression of colon cancer

Norepinephrine‐CREB1‐miR‐373 axis promotes progression of colon cancer

The Multiple Roles of Hepatitis B Virus X Protein (HBx) Dysregulated MicroRNA in Hepatitis B Virus-Associated Hepatocellular Carcinoma (HBV-HCC) and Immune Pathways

Emerging trends in the novel drug delivery approaches for the treatment of lung cancer

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