Therapeutic Properties of Flavonoids in Treatment of Cancer through Autophagic Modulation: A Systematic Review

Silva, Guilherme Vinício de Sousa; Lopes, Ana Luiza Vieira Ferreira Guimarães; Viali, Isis Carolina; Lima, Lucas Zannini Medeiros; Bizuti, Matheus Ribeiro; Haag, Fabiana Brum; Silva, Débora Tavares de Resende e

doi:10.1007/s11655-022-3674-9

Cited by 8 publications

(3 citation statements)

References 76 publications

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“…To date, small molecules such as mitoxantrone, berberine, TMPyP4, and IMC-48 have been reported as potential i-motif ligands. Flavonoids are polyphenolic natural compounds that are present in a variety of fruits, grains, nuts, wine, tea, vegetables, and other foods. , They are known to have a variety of health-beneficial properties with high potency and minimal systemic toxicity . Flavonoid molecules have a basic diphenyl propane skeleton (also known as C 6 –C 3 –C 6 ), which consists of two benzene rings (A- and B-rings) joined by a heterocyclic pyran or pyrone ring (C-ring) in the center (Figure a).…”

Section: Introductionmentioning

confidence: 99%

Uncovering the Contrasting Binding Behavior of Plant Flavonoids Fisetin and Morin Having Subsidiary Hydroxyl Groups (−OH) with HRAS1 and HRAS2 i-Motif DNA Structures: Decoding the Structural Alterations and Positional Influences

Bag,

Ghosal,

Karmakar

et al. 2023

ACS Omega

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Research on the interactions of naturally existing flavonoids with various noncanonical DNA such as i-motif (IM) DNA structures is helpful in comprehending the molecular basis of binding mode as well as providing future direction for the application and invention of novel effective therapeutic drugs. IM DNA structures have been identified as prospective anticancer therapeutic targets, and flavonoids are smaller molecules with a variety of health-promoting attributes, including anticancer activities. The extensive investigation comprising a series of techniques reveals the contrasting mode of the binding behavior of fisetin and morin with various IM DNA structures. We have discovered that structural alterations of hydroxyl groups located at different places of aromatic rings influence flavonoid’s reactivity. This minor structural alteration appears to be critical for fisetin and morin’s capacity to interact differentially with HRAS1 and HRAS2 IM DNA. Hence, fisetin appears to be an efficient ligand for HRAS1 and morin is considered to be an efficient ligand for HRAS2 IM DNA. This novel exploration opens up the possibility of employing the strategy for regulation of gene expression in cancerous cells. Our finding also reveals the flavonoid-mediated specific interaction with IM DNA while pointing toward tangible strategies for drug discovery and other essential cellular functions.

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Section: Introductionmentioning

confidence: 99%

Uncovering the Contrasting Binding Behavior of Plant Flavonoids Fisetin and Morin Having Subsidiary Hydroxyl Groups (−OH) with HRAS1 and HRAS2 i-Motif DNA Structures: Decoding the Structural Alterations and Positional Influences

Bag,

Ghosal,

Karmakar

et al. 2023

ACS Omega

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“…Among them, the energy consumption in protein synthesis is high, so mRNA translation is closely and directly controlled by mTOR signals. mTOR also plays a role in the inhibition of autophagy and inhibits protein catabolism [37]. During autophagy, unwanted or dysfunctional components are removed and recirculated by lysosomal dependent mechanisms.…”

Section: Structure and Distribution Of Orexin And Its Receptorsmentioning

confidence: 99%

the inhibitory effect of Orexin system on different diseases through mTOR signaling pathway

song

wang

et al. 2022

Preprint

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Orexins, also known as hypocretins, are two neuropeptides secreted from orexin-containing neurons, mainly in the lateral hypothalamus (LH). The mTOR pathway is an essential component of the Orexin/GPCR downstream signaling network and can be activated and activated by Orexin. This review article summarizes the Orexin system and its inhibition of various diseases through mTOR signaling pathway. In addition, the potential of targeting the Orexin system for treating a wide range of conditions is discussed.

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“…They are considered one of the promising chemopreventive agents for cancer (de Sousa Silva et al, 2023; Ferreira et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

A comprehensive view on the apigenin impact on colorectal cancer: Focusing on cellular and molecular mechanisms

Daneshvar,

Zamanian,

Ivraghi

et al. 2023

Food Science & Nutrition

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Colon cancer (CC) is one of the most common and deadly cancers worldwide. Oncologists are facing challenges such as development of drug resistance and lack of suitable drug options for CC treatment. Flavonoids are a group of natural compounds found in fruits, vegetables, and other plant‐based foods. According to research, they have a potential role in the prevention and treatment of cancer. Apigenin is a flavonoid that is present in many fruits and vegetables. It has been used as a natural antioxidant for a long time and has been considered due to its anticancer effects and low toxicity. The results of this review study show that apigenin has potential anticancer effects on CC cells through various mechanisms. In this comprehensive review, we present the cellular targets and signaling pathways of apigenin indicated to date in in vivo and in vitro CC models. Among the most important modulated pathways, Wnt/β‐catenin, PI3K/AKT/mTOR, MAPK/ERK, JNK, STAT3, Bcl‐xL and Mcl‐1, PKM2, and NF‐kB have been described. Furthermore, apigenin suppresses the cell cycle in G2/M phase in CC cells. In CC cells, apigenin‐induced apoptosis is increased by inhibiting the formation of autophagy. According to the results of this study, apigenin appears to have the potential to be a promising agent for CC therapy, but more research is required in the field of pharmacology and pharmacokinetics to establish the apigenin effects and its dosage for clinical studies.

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Therapeutic Properties of Flavonoids in Treatment of Cancer through Autophagic Modulation: A Systematic Review

Cited by 8 publications

References 76 publications

Uncovering the Contrasting Binding Behavior of Plant Flavonoids Fisetin and Morin Having Subsidiary Hydroxyl Groups (−OH) with HRAS1 and HRAS2 i-Motif DNA Structures: Decoding the Structural Alterations and Positional Influences

Uncovering the Contrasting Binding Behavior of Plant Flavonoids Fisetin and Morin Having Subsidiary Hydroxyl Groups (−OH) with HRAS1 and HRAS2 i-Motif DNA Structures: Decoding the Structural Alterations and Positional Influences

the inhibitory effect of Orexin system on different diseases through mTOR signaling pathway

A comprehensive view on the apigenin impact on colorectal cancer: Focusing on cellular and molecular mechanisms

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