Therapeutic potentials of Vachellia nilotica (L.) extracts in Hepatitis C infection: A review

Ahovegbe, Lucrece; Ogwang, Patrick Engeu; Peter, Emanuel L.; Mtewa, Andrew G.; Kasali, Félicien Mushagalusa; Tolo, Casim Umba; Gbenoudon, J.; Weisheit, Anke; Pakoyo, Kamba F.

doi:10.1016/j.sciaf.2021.e00918

Cited by 6 publications

(2 citation statements)

References 79 publications

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“…Kankara et al (2017), for example reported the effect of V. nilotica in wound healing by suppressing oxidative stress and pro-inflammatory cytokines. Vachellia nilotica's immunomodulatory effects showed by its ability to proliferate immune cells and inhibit immunosuppressive cytokines was also earlier reported (Ahovègbé, et al 2021). In another study, it was reported that Adansonia digitata leaf, root bark and fruit pulp methanol extracts displayed promising immunomodulatory property based on their ability to stimulate T-cells via increase in delayedtype hypersensitivity (Sharma & Rangali, 2016).…”

Section: Ethnopharmacological Relevance Of the Cited Speciesmentioning

confidence: 58%

Indigenous traditional knowledge of medicinal plants used for the management of HIV / AIDS opportunistic infections in Katsina State, Nigeria

Kankara

Nuhu

Haruna³

et al. 2022

Ethnobot. Res. App.

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Background: Medicinal plants are widely used for the management of many diseases including HIV / AIDS opportunistic infections in Katsina State, North-western part of Nigeria. The usage of those plants is, however, poorly documented.Method: An ethnobotanical study was conducted to document medicinal plants used for the management of HIV / AIDS opportunistic infections in three Local Government Areas (one from each Senatorial Zone) of Katsina State, Nigeria. Information was obtained through a semi-structured questionnaire administered to 150 respondents comprising traditional healers, herbalists, farmers and HIV / AIDS patients.Results: The survey revealed 48 plant species distributed among 44 genera and 28 families. The highest Relative Frequency of Citation was observed in Anogeissus leiocarpa (DC.) Guill. and Perr (0.75). Fabaceae represented by 11 species appeared to be the most utilised family. Highest Informant Consensus factor was observed in abnormal vaginal discharge and genital ulcer. Most of the cited species are trees that are sourced from the wild and majority of medications are prepared in the form of decoction which is taken orally. The most used plant parts were leaves (40%). Conclusion:The study revealed substantial numbers and knowledge of medicinal plants used for the treatment of HIV / AIDS related infections in Katsina State, Nigeria. Further investigations to establish the pharmacological potentials of the cited species with regard to the treatment of HIV / AIDS are highly recommended.

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Section: Ethnopharmacological Relevance Of the Cited Speciesmentioning

confidence: 58%

Indigenous traditional knowledge of medicinal plants used for the management of HIV / AIDS opportunistic infections in Katsina State, Nigeria

Kankara

Nuhu

Haruna³

et al. 2022

Ethnobot. Res. App.

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“…DNA viruses, viruses belonging to Herpesviridae, Poxviridae, and Papillomaviridae were targeted using V. nilotica , and resulted in anti-bovine herpes virus and direct virucidal activity against goatpox virus. The meta-analysis inferred that V. nilotica could be a promising source of anti-hepatitis C virus drug leads with the ability to prevent its long-term sequelae while promoting immune competence [ 144 ]. Additionally, another study aimed to assess the cytotoxic and antiviral activity of an aqueous leaf extract of A. catechu against the new castle disease virus (NDV) on human peripheral blood mononuclear cells (PBMC).…”

Section: Pharmacological Activitiesmentioning

confidence: 99%

Bioactive Compounds, Pharmacological Actions, and Pharmacokinetics of Genus Acacia

et al. 2022

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Plants are a promising source of bioactive compounds that can be used to tackle many emerging diseases both infectious and non-infectious. Among different plants, Acacia is a very large genus and exhibits a diverse array of bioactive agents with remarkable pharmacological properties against different diseases. Acacia, a herb found all over the world, contains approximately more than 1200 species of the Fabaceae family. In the present review, we have collected detailed information on biochemical as well as pharmacological properties. The data were retrieved using different databases, such as Elsevier, PubMed, Science Direct, Google Scholar, and Scopus, and an extensive literature survey was carried out. Studies have shown that Acacia possesses several secondary metabolites, including amines, cyanogenic glycosides, flavonoids, alkaloids, seed oils, cyclitols, fluoroacetate, gums, non-protein amino acids, diterpenes, fatty acids, terpenes, hydrolyzable tannins, and condensed tannins. These compounds exhibit a wide range of pharmaceutical applications such as anti-inflammatory, antioxidant, antidiarrheal, antidiabetic, anticancer, antiviral, liver protective effects, and so on. Thus, the literature shows the tremendous phytochemical impact of the genus Acacia in medicine. Overall, we recommend that more research should be conducted on the medicinal value and isolation and purification of the effective therapeutic agents from Acacia species for the treatment of various ailments.

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UV‐spectrophotometric and spectroscopic observed Vachellia nilotica and Nigella sativa formulations regularized the histopathological and biochemical parameters during wound contraction

Shahzad,

Ali,

Farooq

et al. 2024

Microscopy Res & Technique

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Diabetes mellitus causes impaired diabetic wounds which is linked to a number of pathological alterations that impede the healing of wounds. In the current research, Swiss albino mice were given alloxan monohydrate to induce diabetes and excision wounds of approximately 6 mm using biopsy punch. The diabetic wounds were treated with various biomaterials including Vachellia nilotica extract (VN), Nigella sativa extract (NS), V. nilotica nanoparticles (VNNPs) and N. sativa nanoparticles (NSNPs). Their effects were determined by evaluating the percent wound contraction, healing time, and histopathological analysis. The serum level of various biochemical parameters that is, pro‐inflammatory cytokines, Matrix metalloproteinases (MMPs) and tissue inhibitor matrix metalloproteinases (TIMPs) were also determined. VNNPs group provided the best outcomes, with wound contraction 100% on 12th day. According to histopathological examination, VNNPs group reduced inflammation and encouraged the formation of blood vessels, fibroblasts, and keratinocytes. VNNPs group significantly alleviated the serum level of pro‐inflammatory cytokines that are, TNF‐α (19.4 ± 1.5 pg/mL), IL‐6 (13.8 ± 0.6 pg/mL), and IL‐8 (24.8 ± 1.2 pg/mL) as compared with the diabetic mice. The serum level of MMP2 (248.2 ± 7.9 pg/mL), MMP7 (316 ± 5.2 pg/mL), and MMP9 (167.8 ± 12.1 pg/mL) in the same group VNNPs were also observed much less than the diabetic mice. The serum level of TIMPs (176.8 ± 2.9 pg/mL) in the VNNPs group was increased maximally with respect to diabetic mice. It is concluded that nanoparticles and biomaterials possess healing properties and have the ability to repair the chronic/diabetic wound.Research Highlights UV‐spectrophotometric and Fourier transform infrared spectroscopy observation for functional group analysis and possible linkage between conjugates Optimization of the histopathological and biochemical markers after application of the formulations Microscopic analysis of epithelial tissues for evaluation of healing mechanisms Speedy contraction of wounds as the alleviation of the inflammatory and necrotic factors

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Therapeutic potentials of Vachellia nilotica (L.) extracts in Hepatitis C infection: A review

Cited by 6 publications

References 79 publications

Indigenous traditional knowledge of medicinal plants used for the management of HIV / AIDS opportunistic infections in Katsina State, Nigeria

Indigenous traditional knowledge of medicinal plants used for the management of HIV / AIDS opportunistic infections in Katsina State, Nigeria

Bioactive Compounds, Pharmacological Actions, and Pharmacokinetics of Genus Acacia

UV‐spectrophotometric and spectroscopic observed Vachellia nilotica and Nigella sativa formulations regularized the histopathological and biochemical parameters during wound contraction

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