Therapeutic potentials of metals in ancient India: A review through Charaka Samhita

Galib,; Barve, Mayur; Mashru, Mayur; Jagtap, Chandrashekhar; Patgiri, Biswajyoti; Prajapati, PK

doi:10.4103/0975-9476.82523

Cited by 108 publications

(57 citation statements)

References 4 publications

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“…The Rasashastra of the Ayurvedic system of medicine deals with medicines of mineral origin. 3 The properties of metal nanoparticles have been widely studied for their antimicrobial activity. Metal nanoparticles such as silver oxide (Ag2O), titanium dioxide (TiO2), silicon (Si), copper oxide (CuO), zinc oxide (ZnO), gold (Au), calcium oxide (CaO) and magnesium oxide (MgO) have demonstrated antimicrobial activity against a spectrum of microorganisms.…”

mentioning

confidence: 99%

Antimicrobial Nanoparticles: applications and mechanisms of action

Fernando¹,

Gunasekara²,

Holton³

2018

Sri Lankan J Infec Dis

136

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Nanoparticle technology is rapidly advancing and is used for a wide range of applications in medicine. The potential of metal nanoparticles as antimicrobial agents is widely studied and is considered as an alternative approach to overcome the challenge posed by multidrug resistance in bacteria. This review discusses novel approaches to nanoparticle synthesis including green synthesis and the antimicrobial spectrum of nanoparticles. Approaches for enhancing antimicrobial potential of nanoparticles by surface modification and its potential as a vehicle for antibiotic delivery are also explored.

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mentioning

confidence: 99%

Antimicrobial Nanoparticles: applications and mechanisms of action

Fernando¹,

Gunasekara²,

Holton³

2018

Sri Lankan J Infec Dis

136

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“…Through process of purification and processing, the metals are becoming biocompatible. In the herbo-mineral preparations, the metals are transforming into very potent drugs [14,15].…”

Section: Discussionmentioning

confidence: 99%

Sophisticated Instrumental Evaluation of Novel Siddha Raw Drug -Manosilai: An Modern Approach towards Drug Standardization

Sureka¹,

Murugesan²,

Madhavan³

2017

Int. J. Adv. Res. Biol. Sci.

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In Siddha system of traditional medicine minerals and animal products are used as main drugs to treat various dreadful diseases. Standardization of Siddha preparations is of utmost important task in establishing the active components of the drug responsible for its biological activity. WHO has emphasized the need to ensure quality control of Indian Medicines including Siddha formulations by using modern techniques and by applying suitable parameters and standards. Siddha practitioners use several metallic preparations to treat diseases such as cancer, urolithiasis, kidney disorders and chronic liver diseases. One such novel drug is Manosilai comprises of arsenic and Sulphur as major components. The main aim of the present study is to purify the Manosilai and to analyses the same with modern sophisticated analytical instrumentation techniques. ICPOES results of the sample manosilai before and after purification reveals the presence of Mercury, Lead, Arsenic and Cadmium along with other trace elements. FT-IR analysis report of both unpurified and purified formulation confirm the presence of biologically significant functional group with characteristic IR absorption frequencies. Further the XRD patter of samples justifies the presence of arsenic sulfide and mercury being the major component of the manosilai. SEM analysis of the sample signifies that the mean particle size of the formulation ranges from 11.21 to 19.37 μm. Hence from the results of the present investigation it was clear that the manosilai purified in accordance with traditional siddha system confirms the stability and complies with the genuinity and standards as per AYUSH guidelines.

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“…The ancient seers of Ayurveda had found that drugs of different origin (herbal, metal, or animal) in addition to codes of conduct and dietary regulations were suitable tools to maintain health in healthy and eradicating diseases in diseased person. [7] The use of metallic preparations in healthcare is a unique feature in this system. Processed metals (mercury, gold, silver, lead, zinc, copper, etc.…”

Section: Review Articlementioning

confidence: 99%

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Pandey

2016

IJGP

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Consumption of metals and minerals are very common in today's life either in the form of medicine or in the form of commercial products. However, the accumulation of free metals above the normal level in human body is the prime cause of metal toxicity. To remove this toxicity from human body chelation therapy is adopted by modern system of medicine, where different chelating agents are described. Chelation therapy is the preferred medical treatment for reducing the toxic effects of metals. Chelating agents are capable of binding to toxic metal ions to form complex structures which are easily excreted from the body removing them from intracellular or extracellular spaces. Ethylenediaminetetraacetic acid and 2,3-Dimercaprol are some of the common chelating agents, which have been used for the chelation of lead or arsenic poisoning. However, serious side effects of these agents have been reported by causing the loss of essential metals and minerals from the body. This may lead researchers to develop less toxic analogs. In Ayurveda (Ayur = life, Veda = science; the science of life) system of medicine, metals and minerals in the form of medicines (Rasaushadhies) are frequently used to treat different diseases. Yet, the ancient scholars of Ayurveda while practicing came to know about the ill-effects of these medicines on human body which may be caused due to the use of medicines made from improper processed metals and minerals. At the same time, they advised to administer various natural substances in the form of antidotes such as honey, ghee, cow's milk, garlic, coriander, turmeric, and coconut water to remove ill effects or toxicity occurred from these medicines. These natural antidotes may consider as chelating agents of Ayurveda, which not only helpful to remove the toxic effects of metal and minerals without causing any side effects but also protect the loss of essential elements from the body. Thus, in this review study, we have tried to correlate the natural antidotes as explained in Ayurveda vis-à-vis with the term chelation or chelating agents of contemporary science.

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Therapeutic potentials of metals in ancient India: A review through Charaka Samhita

Cited by 108 publications

References 4 publications

Antimicrobial Nanoparticles: applications and mechanisms of action

Antimicrobial Nanoparticles: applications and mechanisms of action

Sophisticated Instrumental Evaluation of Novel Siddha Raw Drug -Manosilai: An Modern Approach towards Drug Standardization

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