Therapeutic potentials of human adipose-derived stem cells on the mouse model of Parkinson's disease

Abstract

The treatment of Parkinson's disease (PD) using stem cells has long been the focus of many researchers, but the ideal therapeutic strategy has not yet been developed. The consistency and high reliability of the experimental results confirmed by animal models are considered to be a critical factor in the stability of stem cell transplantation for PD. Therefore, the aim of this study was to investigate the preventive and therapeutic potential of human adipose-derived stem cells (hASC) for PD and was to identify the related factors to this therapeutic effect. The hASC were intravenously injected into the tail vein of a PD mouse model induced by 6-hydroxydopamine. Consequently, the behavioral performances were significantly improved at 3 weeks after the injection of hASC. Additionally, dopaminergic neurons were rescued, the number of structure-modified mitochondria was decreased, and mitochondrial complex I activity was restored in the brains of the hASC-injected PD mouse model. Overall, this study underscores that intravenously transplanted hASC may have therapeutic potential for PD by recovering mitochondrial functions.

HGF and BFGF Secretion by Human Adipose-Derived Stem Cells Improves Ovarian Function During Natural Aging via Activation of the SIRT1/FOXO1 Signaling Pathway

“…Although data from several studies suggest that hADSCs play a pivotal role in wound healing, anti-neural aging and skin aging [21, 22, 27], few studies have revealed how hADSCs work during this period. Little is known about the mechanism of hADSCs in resisting NOA.…”

“…hADSCs represent several advantages that make them suitable for clinical therapy: they can be isolated an abundant tissue source, they are stably proliferative and poorly immunogenic, and they have a low injury risk, thus holding great promise for autologous cell repair and regeneration. It has been shown that adipose-derived stem cells (ADSCs) are able to directly or indirectly (through a paracrine effect, releasing cytokines) participate in the regeneration process [21, 22]. Previous studies have shown that basic fibroblast growth factor (bFGF) and hepatocyte growth factor (HGF) are secreted from multiple mesenchymal stem cells, such as BMSCs, human amniotic fluid stem cells and human menstrual blood stem cells [23].…”

Recent trends in the development of nanophytobioactive compounds and delivery systems for their possible role in reducing oxidative stress in Parkinson’s disease models

“…3,36,[40][41][42][43] Extensive animal model studies have been conducted about the sustained protective role of different synthetic and natural bioactive compounds against dopaminergic neuron loss in PD. [44][45][46][47][48][49] Based on limitations for using synthetic compounds, [50][51][52] natural phytobioactive compounds play an important role in preventing PD. 38,48 Phytobioactive compounds from various medicinal plants show neuroprotective effects in various animal models.…”

Functional role of mesenchymal stem cells in the treatment of chronic neurodegenerative diseases

“…As a result, methamphetamine stimulated rotational behavior was inhibited and the number of tyrosine hydroxylase (TH) positive neurons (i.e., dopaminergic neurons) in the SNpc was significantly preserved, likely due to anti‐inflammatory mechanisms related to modulation of microglial activation. Improvements of the behavioural performance were confirmed also after 3 weeks from intravenous administration of hASCs in the same rat model (Choi et al, ). Moreover, nigral dopaminergic neurons were better preserved and the number of altered mitochondria was decreased.…”