Therapeutic potentials of curcumin in the treatment of glioblstoma

Shabaninejad, Zahra; Pourhanifeh, Mohammad Hossein; Movahedpour, Ahmad; Mottaghi, Reza; Nickdasti, Ali; Mortezapour, Erfan; Shafiee, Alimohammad; Hajighadimi, Sarah; Moradizarmehri, Sanaz; Sadeghian, Mohammad Hadi; Mousavi, Seyed Mojtaba; Mirzaei, Hamed

doi:10.1016/j.ejmech.2020.112040

Cited by 49 publications

(34 citation statements)

References 106 publications

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“…As a result, that mediation of IL-6 and soluble IL-6 receptor secretion by the miR-145-ADAM17 pathway has been revealed that could played a role in maintaining the CSC characteristics in a paracrine way. Curcumin is a natural compounds that could be used in the treatment of different diseases such as cancer [168][169][170][171][172][173][174][175]. The curcumin delivery attenuated the tumor expansion in vivo by enhancing the miR-145 promoter activities [167].…”

Section: Micrornasmentioning

confidence: 99%

Cancer stem cells and oral cancer: insights into molecular mechanisms and therapeutic approaches

2020

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Cancer stem cells (CSCs) have been identified as a little population of cancer cells, which have features as the same as the cells normal stem cells. There is enough knowledge of the CSCs responsibility for metastasis, medicine resistance, and cancer outbreak. Therefore, CSCs control possibly provides an efficient treatment intervention inhibiting tumor growth and invasion. In spite of the significance of targeting CSCs in treating cancer, few study comprehensively explored the nature of oral CSCs. It has been showed that oral CSCs are able to contribute to oral cancer progression though activation/inhibition a sequences of cellular and molecular pathways (microRNA network, histone modifications and calcium regulation). Hence, more understanding about the properties of oral cancers and their behaviors will help us to develop new therapeutic platforms. Head and neck CSCs remain a viable and intriguing option for targeted therapy. Multiple investigations suggested the major contribution of the CSCs to the metastasis, tumorigenesis, and resistance to the new therapeutic regimes. Therefore, experts in the field are examining the encouraging targeted therapeutic choices. In spite of the advancements, there are not enough information in this area and thus a magic bullet for targeting and eliminating the CSCs deviated us. Hence, additional investigations on the combined therapies against the head and neck CSCs could offer considerable achievements. The present research is a review of the recent information on oral CSCs, and focused on current advancements in new signaling pathways contributed to their stemness regulation. Moreover, we highlighted various therapeutic approaches against oral CSCs.

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Section: Micrornasmentioning

confidence: 99%

Cancer stem cells and oral cancer: insights into molecular mechanisms and therapeutic approaches

2020

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“…Утверждается, что куркума широко использовалась при лечении различных заболеваний более 2500 лет, в основном в азиатских странах [21,22]. Современные данные свидетельствуют о том, что куркумин может быть полезен при лечении широкого спектра заболеваний человека, включая болезнь Альцгеймера [23], болезнь Паркинсона [20], диабет, сердечно-сосудистые заболевания, артрит и различные новообразования, включая опухоли головного мозга [8,12].…”

Section: общие сведения о куркуминеunclassified

“…Отчасти это объясняется тем, что глиальные опухоли -высокогетерогенная группа новообразований как на клеточном, так и на генетическом уровне. Патогенез МГБ недостаточно изучен, однако показано, что нарушения в регуляции клеточных сигнальных путей и генетические мутации играют решающую роль в возникновении, инвазии и прогрессировании этого заболевания [12]. Кроме того, для МГБ характерно отсутствие резких границ между опухолью и здоровой тканью мозга, что затрудняет удаление всех опухолевых клеток и служит причиной развития рецидива и роста опухоли [13].…”

Section: Introductionunclassified

“…Таким образом, МГБ представляет собой одну из самых сложных проблем современной медицины и тре-бует разработки новых методов лечения. В последние десятилетия активно изучают химиотерапевтическую эффективность природных соединений и их производных для лечения злокачественных опухолей человека [12].…”

Section: Introductionunclassified

“…Противоопухолевая активность куркумина обусловлена множеством биохимических механизмов, включая воздействие на мутагенез, онкогенез, метастазирование, регуляцию клеточного цикла, апоптоз и аутофагию [15]. Необходимо отметить, что липофильные свойства куркумина и способность проникать через гематоэнцефалический барьер (ГЭБ) делают его потенциальным терапевтическим и протекторным средством при ряде неврологических заболеваний [16] и злокачественных новообразований, связанных с центральной нервной системой [12].…”

Section: Introductionunclassified

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The therapeutic potential of curcumin for the treatment of glioblastoma multiforme

et al. 2020

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Glioblastoma multiforme (GBM), a grade IV astrocytoma, is the most common and deadly type of primary malignant brain tumor, with a patien’s median survival rate ranging from 12 to 15 months. Over the last fifteen years, the treatment for GBM has included maximal safe surgical resection with combination radiotherapy and adjuvant temozolomide chemotherapy. The low efficacy of mentioned therapies has forced researchers to explore an appropriate alternative or complementary treatment for GBM. It has been shown that curcumin has therapeutic potentials to fight against GBM via affecting on cell proliferation, apoptosis, cell cycle, invasion and angiogenesis pathways. In addition, curcumin possess a synergistic impact with chemotherapeutic agents. Herein, we summarized the current findings on curcumin as potential therapeutic agent in the treatment of GBM.

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Versatile role of curcumin and its derivatives in lung cancer therapy

Ashrafizadeh

Najafi

Makvandi

et al. 2020

Journal Cellular Physiology

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Lung cancer is a main cause of death all over the world with a high incidence rate. Metastasis into neighboring and distant tissues as well as resistance of cancer cells to chemotherapy demand novel strategies in lung cancer therapy. Curcumin is a naturally occurring nutraceutical compound derived from Curcuma longa (turmeric) that has great pharmacological effects, such as anti‐inflammatory, neuroprotective, and antidiabetic. The excellent antitumor activity of curcumin has led to its extensive application in the treatment of various cancers. In the present review, we describe the antitumor activity of curcumin against lung cancer. Curcumin affects different molecular pathways such as vascular endothelial growth factors, nuclear factor‐κB (NF‐κB), mammalian target of rapamycin, PI3/Akt, microRNAs, and long noncoding RNAs in treatment of lung cancer. Curcumin also can induce autophagy, apoptosis, and cell cycle arrest to reduce the viability and proliferation of lung cancer cells. Notably, curcumin supplementation sensitizes cancer cells to chemotherapy and enhances chemotherapy‐mediated apoptosis. Curcumin can elevate the efficacy of radiotherapy in lung cancer therapy by targeting various signaling pathways, such as epidermal growth factor receptor and NF‐κB. Curcumin‐loaded nanocarriers enhance the bioavailability, cellular uptake, and antitumor activity of curcumin. The aforementioned effects are comprehensively discussed in the current review to further direct studies for applying curcumin in lung cancer therapy.

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Therapeutic potentials of curcumin in the treatment of glioblstoma

Cited by 49 publications

References 106 publications

Cancer stem cells and oral cancer: insights into molecular mechanisms and therapeutic approaches

Cancer stem cells and oral cancer: insights into molecular mechanisms and therapeutic approaches

The therapeutic potential of curcumin for the treatment of glioblastoma multiforme

Versatile role of curcumin and its derivatives in lung cancer therapy

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