Therapeutic potentials of crocin in medication of neurological disorders

Ahmed, Salman; Hasan, Muhammad Mohtasheemul; Heydari, Mojtaba; Rauf, Abdur; Bawazeer, Sami; Abu-Izneid, Tareq; Rebezov, Мaksim; Shariati, Mohammad Ali; Daglia, Maria; Rengasamy, Kannan R.R.

doi:10.1016/j.fct.2020.111739

Cited by 31 publications

(21 citation statements)

References 90 publications

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“…Crocin is a natural carotenoid compound derived from the gardenia and crocus flowers, showing potential therapeutic effects in the alleviation of various neurological disorders [ 116 ]. The neuroprotective action of crocin is related to its anti-inflammatory, antioxidant, and anti-apoptotic activities [ 116 ].…”

Section: Emerging Natural/pharmaceutical Therapeutics To Modulate Er ...mentioning

confidence: 99%

ER stress and UPR in Alzheimer’s disease: mechanisms, pathogenesis, treatments

et al. 2022

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Alzheimer’s disease (AD) is a devastating neurodegenerative disorder characterized by gradual loss of memory and cognitive function, which constitutes a heavy burden on the healthcare system globally. Current therapeutics to interfere with the underlying disease process in AD is still under development. Although many efforts have centered on the toxic forms of Aβ to effectively tackle AD, considering the unsatisfactory results so far it is vital to examine other targets and therapeutic approaches as well. The endoplasmic reticulum (ER) stress refers to the build-up of unfolded or misfolded proteins within the ER, thus, perturbing the ER and cellular homeostasis. Emerging evidence indicates that ER stress contributes to the onset and development of AD. A thorough elucidation of ER stress machinery in AD pathology may help to open up new therapeutic avenues in the management of this devastating condition to relieve the cognitive dementia symptoms. Herein, we aim at deciphering the unique role of ER stress in AD pathogenesis, reviewing key findings, and existing controversy in an attempt to summarize plausible therapeutic interventions in the management of AD pathophysiology.

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Section: Emerging Natural/pharmaceutical Therapeutics To Modulate Er ...mentioning

confidence: 99%

ER stress and UPR in Alzheimer’s disease: mechanisms, pathogenesis, treatments

et al. 2022

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“…A small proportion of studies investigated the medicinal benefits of crocin and safranal as the main active ingredients of saffron. For example, antidepressant and aphrodisiac properties of saffron is considered to be more secondary to the crocin content [14,15], while anti-asthmatic and anti-cancer effects are reported to be more contributed to safranal [16,17]. Our study showed that despite the observed improvement in all treated groups' wound healing process compared to control, there was a marked superiority in the histopathologic stage of wound healing in saffron treated rats compared to safranal and crocin treated ones.…”

Section: Discussionmentioning

confidence: 49%

Wound Healing Potential of Crocin and Safranal, Main Saffron (Crocus sativus L.), the Active Constituents in Excision Wound Model in Rats

Deldar

Monsefi

Salmanpour

et al. 2021

GMJ

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Background: Saffron is traditionally suggested for wound healing in Persian medicine. It is investigated for wound healing effect in multiple studies with promising results. It is not examined that which ingredient of saffron contributes more to this effect. This study was aimed to evaluate and compare the wound healing potential of saffron and its active constituents, crocin, and safranal, in rats. Materials and Methods: Forty female adult rats with induced excision wounds were randomly divided into four groups to receive topical formulation of saffron, crocin, safranal, and placebo for seven days. The Wound area and histopathologic stage of wound healing were evaluated as outcome measures. Results: The wound area was significantly lower in treatment groups (saffron, crocin, and safranal) compared to the control group on day 7 of the intervention. Compared to the control group, the wound in all treated groups showed a decreased inflammatory response and more progression to the proliferation phase. The saffron group showed more advanced healing phase with complete epithelialization of the wound on day 7 of study when partial and no epithelialization was observed in safranal and crocin groups. Conclusion: The study showed the wound healing properties of both safranal and crocin with the slight superiority of safranal. However, saffron seems to be more potent in wound healing effect compared to safranal and crocin as its main active constituents. [GMJ.2021;10:e1900]

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“…Terpenoids are essential constituents in HLJDD, including the subtypes of monoterpenes, sesquiterpenes, diterpenes, and triterpenes. Monoterpenes and diterpenes, as represented by iridoids and yellow pigments, are generally regarded as the main bioactive and characteristic components of HLJDD [28,[32][33][34]. For example, geniposide, a representative iridoid, exerts diverse pharmacological effects, including anti-inflammatory, hepatoprotective, and cardiovascular-protective effects, among others [28].…”

Section: Characterization Of Terpenoidsmentioning

confidence: 99%

An enhanced analytical strategy integrating offline two‐dimensional liquid chromatography with high‐resolution accurate mass spectrometry and molecular networking: Comprehensive characterization of HuangLian JieDu Decoction as a case study

Sun

et al. 2022

J of Separation Science

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Comprehensive ingredient research is of great significance for understanding the effective material basis of herbal medicines, but due to the diversity and complexity of their phytochemicals, such research is challenging. Here, a multifaceted strategy was proposed to analyze and identify the composition of HuangLian JieDu Decoction based on offline two‐dimensional liquid chromatography combined with ultraviolet detection and high‐resolution mass spectrometry. Multiple components were separated by two‐dimensional liquid chromatography, which consisted of hydrophilic interaction chromatography and reversed‐phase liquid chromatography, and then further characterized by high‐resolution mass spectrometry with a full mass spectrometry/precursor ion list/data‐dependent secondary scan data acquisition method. For data processing, database screening and molecular networking were used to identify the components in HuangLian JieDu Decoction. The offline two‐dimensional liquid chromatography combined with ultraviolet detection and a high‐resolution mass spectrometry system showed good orthogonality of 76.35% and a high peak capacity of 5175, effectively separating multiple components. Finally, 527 compounds, including 164 alkaloids, 133 terpenoids, 88 flavonoids, 60 phenylpropanoids, 38 organic acids, and 44 other compounds, were characterized. This integrated approach is suitable for the comprehensive characterization of herbal medicines and other complex chemical systems.

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Therapeutic potentials of crocin in medication of neurological disorders

Cited by 31 publications

References 90 publications

ER stress and UPR in Alzheimer’s disease: mechanisms, pathogenesis, treatments

ER stress and UPR in Alzheimer’s disease: mechanisms, pathogenesis, treatments

Wound Healing Potential of Crocin and Safranal, Main Saffron (Crocus sativus L.), the Active Constituents in Excision Wound Model in Rats

An enhanced analytical strategy integrating offline two‐dimensional liquid chromatography with high‐resolution accurate mass spectrometry and molecular networking: Comprehensive characterization of HuangLian JieDu Decoction as a case study

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