Therapeutic potential role of exosomes for ischemic stroke

Zhu, Zhihan; Kalyan, Bikram Shah; Chen, Lukui

doi:10.26599/bsa.2019.9050013

Cited by 1 publication

(1 citation statement)

References 77 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Эти факторы не только спасают поврежденные клетки мозга, но и ускоряют регенерацию собственных стволовых клеток. Трофические факторы способствуют пролиферации клеток-предшественников нейронов хозяина, особенно тех, которые расположены вокруг субвентрикулярной зоны (SVZ) и обычно неактивны [27][28][29].…”

Section: типы внеклеточных везикулunclassified

Cell therapy for ischemic stroke

Botev¹,

Gryb²

2020

Ukr Neurosurg J

View full text Add to dashboard Cite

Stroke is the second, and in some countries the third cause of mortality in the population and one of the causes of disability in the adult population. According to statistics, in 2018, 15 million cases of stroke and 6 million deaths were diagnosed, The only currently approved treatments for acute stroke are intravenous tissue plasminogen activator (rtPA) and intra-arterial thrombectomy, which are used in less than 10% and 1% of patients, respectively.The literature review is devoted to the pathophysiology and molecular mechanisms of damage in cerebral ischemia. The modern concept of two strategies of cell therapy is discussed: neuroprotection and remodeling; the role of stem cells in reducing local and systemic inflammation, neurogenesis and angiogenesis, increasing neuronal plasticity, and protecting the bloodbrain barrier, the role of paracrine factors and extracellular vesicles is shown. Methods of stem cell delivery are described: direct intracerebral transplantation, intraventricular and intrathecal, intravenous and intraarterial; the number of cells, their type and optimal delivery time depending on the acute, subacute and chronic periods of stroke. We also described recently designed the radially branched deployment (RBD) device and Cleveland multiport catheter for convection-enhanced delivery in which a cell-delivery catheter can be deployed at various angles and depths from a single longitudinal cannula. Finally, data on the completed 15 clinical trials from 2015 to the present, in which 513 patients took part, are presented. A detailed analysis of the efficacy and safety of cell therapy has been carried out.

show abstract

Section: типы внеклеточных везикулunclassified

Cell therapy for ischemic stroke

Botev¹,

Gryb²

2020

Ukr Neurosurg J

View full text Add to dashboard Cite

show abstract

Therapeutic potential role of exosomes for ischemic stroke

Cited by 1 publication

References 77 publications

Cell therapy for ischemic stroke

Cell therapy for ischemic stroke

Contact Info

Product

Resources

About