Therapeutic Potential of Virgin Coconut Oil in Ameliorating
Diabetes Mellitus and Hepatotoxicity Using Rattus Norvegicus as
Case Study

Okpiabhele, A.O.; Nw, E.A.C.; Abu, O.D.

doi:10.3923/ajbs.2018.138.144

Cited by 6 publications

(7 citation statements)

References 13 publications

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“…However, treatment of the diabetic Wistar albino rats with two different doses of ethanol extract of C. sativus fruit markedly reduced the FBG concentration and body weights of rats, but enhanced the activity/concentration of antioxidant enzymes/molecules in pancreatic tissue. These results are in agreement with those of previous studies [28][29][30][31][32][33]. The results suggest that oxidative stress plays a crucial role in STZ-induced diabetes mellitus and that increased ROS production suppresses the activity of antioxidant enzymes, while diminishing the levels of antioxidant molecules in pancreatic tissue.…”

Section: Discussionsupporting

confidence: 93%

"Protective Property of Ethanol Extract of C. Sativus on STZ-Induced Diabetic Rat Pancreas"

2023

BJSTR

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The present study investigated the protective property of ethanol extract of Cucumis sativus on streptozotocin (STZ)-induced diabetic rat pancreas. Male albino rats of Wistar strain (n = 25, mean weight = 215 ± 15 g) were assigned to five groups (5 rats/group): normal control, diabetic control, metformin, extract (200 mg/ kg body weight, bwt) and extract (300 mg/kg bwt) groups. A single intraperitoneal injection of 50 mg/kg bwt STZ was used to induce diabetes mellitus in the experimental rats. The diabetic rats were treated for a period of 21 days with 50 mg/kg bwt metformin (standard antidiabetic agent) or the extract. Activities of catalase, superoxide dismutase (SOD), glutathione peroxidase (GPx) and glutathione reductase (GR) as well as glutathione (GSH), total protein (TP), malondialdehyde (MDA) and nitric oxide (NO) levels were measured in pancreatic tissue. The results showed that the diabetogenic agent STZ significantly increased the fasting blood glucose (FBG) concentrations of the rats, but it decreased the activity/concentration of antioxidant enzymes/molecules (p < 0.05). However, treatment of the diabetic Wistar albino rats with 200 and 300 mg/kg bwt extract markedly reduced the FBG concentration and body weights of rats, but enhanced the activity/concentration of antioxidant enzymes/molecules in pancreatic tissue (p < 0.05). These results indicate that ethanol extract of C. sativus fruit has the potential to promote antioxidant defense in STZ-induced diabetic rats pancreas.

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Section: Discussionsupporting

confidence: 93%

"Protective Property of Ethanol Extract of C. Sativus on STZ-Induced Diabetic Rat Pancreas"

2023

BJSTR

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“…However, treatment of diabetic rats with ethanol extract of C. sativus significantly increased the activities of the antioxidant enzymes as well as NO level, but it did not significantly alter cardiac TP concentration. These results are in conformity with reports of previous studies [58][59][60][61]. The cardioprotective effect of medicinal plants may involve attenuation of the damage in cardiac muscle cells, vascular smooth muscle cells (VSMCs), endothelial cells (ECs), and macrophages and monocytes.…”

Section: Discussionsupporting

confidence: 93%

Cardiac Oxidative Status in Diabetic Wistar Rats Exposed To Ethanol Extract of Cucumis Sativus Fruit

OD,

2023

J Diagn Case Rep

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The present study investigated cardiac oxidative status in diabetic Wistar rats exposed to ethanol extract of Cucumis sativus fruit. Male Wistar albino rats (n = 25, mean weight = 215 ± 15 g) were randomly assigned to five groups of 5 rats each: normal control, diabetic control, metformin, extract (200 mg/kg body weight, bwt) and extract (300 mg/kg bwt) groups. Diabetes mellitus was induced in the rats via intraperitoneal injection of 50 mg/kg bwt STZ. The diabetic rats were treated for 21 days with either metformin (50 mg/kg bwt) or the extract. Activities of antioxidant enzymes such as catalase, superoxide dismutase (SOD), glutathione peroxidase (GPx) and glutathione reductase (GR) as well as molecules like reduced glutathione (GSH), total protein (TP), malondialdehyde (MDA) and nitric oxide (NO) were measured in heart homogenate. The results showed that induction of diabetes mellitus with STZ significantly increased the fasting blood glucose (FBG) concentrations of the rats, while decreasing the activity/concentration of antioxidant enzymes/ molecules (p < 0.05). However, treatment of the diabetic Wistar rats with the extract markedly reduced the FBG concentration and body weights of rats, but enhanced the activity/concentration of antioxidant enzymes/molecules in cardiac tissue (p < 0.05). These results indicate that ethanol extract of the medicinal plant fruit has the potential to promote antioxidant defense in the heart of STZ-induced diabetic rats.

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“…Lauric acid can increase insulin secretion. Increased insulin secretion causes the search for glucose alternatives to be reduced and free radical by-products are produced less so that pancreatic beta cell damage can be inhibited 15 .…”

Section: Resultsmentioning

confidence: 99%

Anti-diabetic Activity of Virgin Coconut Oil (VCO): Review

Rahmawati

Putra

Wiyani

et al. 2023

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Diabetes mellitus is a metabolic disease characterized by increased blood glucose levels. Currently, the treatment of diabetes mellitus uses synthetic or chemical drugs and natural ingredients such as virgin coconut oil. Virgin coconut oil (VCO) is extracted with minimal heating and no chemical purification process. This study aims to obtain data on the impact of VCO as an antidiabetic obtained from several research journals. This literature study uses a narrative review method obtained from the Google Scholar, Pubmed, and Science Direct databases. The results of this study indicate that VCO can be used as an alternative to lowering blood glucose levels because it has antidiabetic activity. Medium-chain fatty acid (MCFA) lauric acid in VCO can stimulate insulin production in pancreatic beta cells. This study concludes that virgin coconut oil can potentially reduce blood sugar levels.

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Therapeutic Potential of Virgin Coconut Oil in Ameliorating Diabetes Mellitus and Hepatotoxicity Using Rattus Norvegicus as Case Study

Cited by 6 publications

References 13 publications

"Protective Property of Ethanol Extract of C. Sativus on STZ-Induced Diabetic Rat Pancreas"

"Protective Property of Ethanol Extract of C. Sativus on STZ-Induced Diabetic Rat Pancreas"

Cardiac Oxidative Status in Diabetic Wistar Rats Exposed To Ethanol Extract of Cucumis Sativus Fruit

Anti-diabetic Activity of Virgin Coconut Oil (VCO): Review

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