Therapeutic potential of toll‐like receptors in treatment of gynecological cancers

Moradi‐Marjaneh, Reyhaneh; Hassanian, Seyed Mahdi; Hasanzadeh, Malihe; Rezayi, Majid; Maftouh, Mona; Mehramiz, Mehrane

doi:10.1002/iub.2011

Cited by 12 publications

(6 citation statements)

References 122 publications

(142 reference statements)

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“…However, strategies to enhance TLR3 signaling could be developed with synergistic targeting of excessive IFN activity. Now that dsRNA receptor agonists, such as rintatolimod (Ampligen), are emerging in other contexts as safe adjuvants for cancer therapies and for other conditions such as chronic fatigue syndrome [118,119], we believe that exploration of dsRNA as a therapy merits further evaluation in cellular and animal models of PAH.…”

Section: Discussionmentioning

confidence: 99%

RNA Signaling in Pulmonary Arterial Hypertension—A Double-Stranded Sword

Turton

Thompson

Farkas

2020

IJMS

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Recognition of and response to pathogens and tissue injury is driven by the innate immune system via activation of pattern recognition receptors. One of the many patterns recognized is RNA and, while several receptors bind RNA, Toll-like receptor 3 (TLR3) is well placed for initial recognition of RNA molecules due to its localization within the endosome. There is a growing body of work describing a role for TLR3 in maintenance of vascular homeostasis. For example, TLR3 deficiency has been shown to play repair and remodeling roles in the systemic vasculature and in lung parenchyma. A hallmark of pulmonary arterial hypertension (PAH) is pulmonary vascular remodeling, yet drivers and triggers of this remodeling remain incompletely understood. Based on its role in the systemic vasculature, our group discovered reduced endothelial TLR3 expression in PAH and revealed a protective role for a TLR3 agonist in rodent models of pulmonary hypertension. This review will provide an overview of RNA signaling in the vasculature and how it relates to PAH pathobiology, including whether targeting double-stranded RNA signaling is a potential treatment option for PAH.

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Section: Discussionmentioning

confidence: 99%

RNA Signaling in Pulmonary Arterial Hypertension—A Double-Stranded Sword

Turton

Thompson

Farkas

2020

IJMS

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“…In spite of progress and advancement in cancer prevention and treatment, it is still one of the most challenge diseases around the world [38][39][40][41][42][43][44][45][46][47]. Troxerutin has indicated great antitumor activity and a number of studies showing its anti-tumor effect are included in this review (Fig.…”

Section: Anti-tumor Effectmentioning

confidence: 99%

Biological and Therapeutic Effects of Troxerutin: Molecular Signaling Pathways Come into View

et al. 2021

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Flavonoids consist a wide range of naturally occurring compounds which are exclusively found in different fruits and vegetables. These medicinal herbs have a number of favourable biological and therapeutic activities such as antioxidant, neuroprotective, renoprotective, anti-inflammatory, anti-diabetic and anti-tumor. Troxerutin, also known as vitamin P4, is a naturally occurring flavonoid which is isolated from tea, coffee and cereal grains as well as vegetables. It has a variety of valuable pharmacological and therapeutic activities including antioxidant, anti-inflammatory, anti-diabetic and anti-tumor. These pharmacological impacts have been demonstrated in in vitro and in vivo studies. Also, clinical trials have revealed the efficacy of troxerutin for management of phlebocholosis and hemorrhoidal diseases. In the present review, we focus on the therapeutic effects and biological activities of troxerutin as well as its molecular signaling pathways.

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“…Dessa forma, são considerados um importante problema de saúde mundial. Essas patologias desenvolvem-se nos órgãos reprodutivos femininos, abrangendo o colo de útero, corpo do útero, ovários, endométrio, vagina e vulva (Moradi-Marjaneh et al 2019).…”

Section: Introductionunclassified

Distribuição da mortalidade por cânceres ginecológicos no estado da Paraíba

Nascimento

Silva

Dantas

2021

PECEN

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Nas mulheres, os cânceres ginecológicos (CG) estão entre as enfermidades mais comuns, tornando-se problema de saúde mundial. Objetivou-se analisar a distribuição do perfil de mortalidade por CG em mesorregiões da Paraíba, durante o período de 1989 a 2018. Trata-se de uma abordagem ecológica, de série temporal, quantitativa e espacial. Os dados foram extraídos do atlas de mortalidade on-line do Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA). A média de óbitos por CG na Paraíba foi equivalente a 1145.5, com maior número de mortes na mesorregião da Mata Paraibana (2056) e no Agreste Paraibano (1358). Todas as mesorregiões apresentaram um crescimento contínuo da média de óbitos ao longo dos anos, sendo maior aumento de óbitos na Borborema (4.5x). Quanto aos tipos de CG, observou-se que a maior média de mortes foi para câncer de colo de útero (227.8) na Mata Paraibana e a menor média de mortes ocorreu na região da Borborema, para câncer de vagina (1.0). Em todas as regiões, foi mais frequente mortes por câncer de útero, seguido de útero Sem Outra Especificação (SOE), ovário, corpo do útero, outros órgãos genitais, vulva e vagina. Conclui-se que há uma crescente mortalidade por CG em toda a Paraíba, com uma heterogeneidade entre regiões e entre tipos de cânceres. Palavras chave: Epidemiologia, mortalidade, saúde da mulher, neoplasia por genitais femininas.

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Therapeutic potential of toll‐like receptors in treatment of gynecological cancers

Cited by 12 publications

References 122 publications

RNA Signaling in Pulmonary Arterial Hypertension—A Double-Stranded Sword

RNA Signaling in Pulmonary Arterial Hypertension—A Double-Stranded Sword

Biological and Therapeutic Effects of Troxerutin: Molecular Signaling Pathways Come into View

Distribuição da mortalidade por cânceres ginecológicos no estado da Paraíba

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