Therapeutic potential of targeting Nrf2 by panobinostat in pituitary neuroendocrine tumors
Yijun Cheng,
Yuting Dai,
Hao Tang
et al.
Abstract:We aimed to identify the druggable cell-intrinsic vulnerabilities and target-based drug therapies for PitNETs using the high-throughput drug screening (HTS) and genomic sequencing methods. We examined 9 patient-derived PitNET primary cells in HTS. Based on the screening results, the potential target genes were analyzed with genomic sequencing from a total of 180 PitNETs. We identified and verified one of the most potentially effective drugs, which targeted the Histone deacetylases (HDACs) both in in vitro and … Show more
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