Therapeutic potential of serotonin 4 receptor for chronic depression and its associated comorbidity in the gut

Agrawal, Lokesh; Korkutata, Mustafa; Vimal, Sunil Kumar; Yadav, Manoj Kumar; Bhattacharyya, Sanjib; Shiga, Takashi

doi:10.1016/j.neuropharm.2020.107969

Cited by 16 publications

(5 citation statements)

References 227 publications

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“…In the present work, mice of both strains showed a region-specific decrease in the mRNA of the Htr1a , Htr4 , and Htr7 genes in the brain structures, wherein most of the changes in the expression of these genes were found in the hypothalamus and hippocampus. On the one hand, there is no doubt that the 5-HT1A [ 42 ], 5-HT4 [ 43 ], and 5-HT7 receptors [ 44 ] play an important role in the pathogenesis and treatment of depressive disorders. On the other hand, many studies have indicated that hippocampal dysfunctions are involved in mood disorders via 5-HT mechanisms [ 45 ].…”

Section: Discussionmentioning

confidence: 99%

Effect of Short Photoperiod on Behavior and Brain Plasticity in Mice Differing in Predisposition to Catalepsy: The Role of BDNF and Serotonin System

Adonina,

Bazhenova,

Bazovkina

2024

IJMS

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Seasonal affective disorder is characterized by depression during fall/winter as a result of shorter daylight. Catalepsy is a syndrome of some grave mental diseases. Both the neurotransmitter serotonin (5-HT) and brain-derived neurotrophic factor (BDNF) are involved in the pathophysiological mechanisms underlying catalepsy and depressive disorders. The aim was to compare the response of behavior and brain plasticity to photoperiod alterations in catalepsy-resistant C57BL/6J and catalepsy-prone CBA/Lac male mice. Mice of both strains were exposed for six weeks to standard-day (14 h light/10 h darkness) or short-day (4 h light/20 h darkness) conditions. Short photoperiod increased depressive-like behavior in both strains. Only treated CBA/Lac mice demonstrated increased cataleptic immobility, decreased brain 5-HT level, and the expression of Tph2 gene encoding the key enzyme for 5-HT biosynthesis. Mice of both strains maintained under short-day conditions, compared to those under standard-day conditions, showed a region-specific decrease in the brain transcription of the Htr1a, Htr4, and Htr7 genes. After a short photoperiod exposure, the mRNA levels of the BDNF-related genes were reduced in CBA/Lac mice and were increased in the C57BL/6J mice. Thus, the predisposition to catalepsy considerably influences the photoperiodic changes in neuroplasticity, wherein both C57BL/6J and CBA/Lac mice can serve as a powerful tool for investigating the link between seasons and mood.

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Section: Discussionmentioning

confidence: 99%

Effect of Short Photoperiod on Behavior and Brain Plasticity in Mice Differing in Predisposition to Catalepsy: The Role of BDNF and Serotonin System

Adonina,

Bazhenova,

Bazovkina

2024

IJMS

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“…As a gut-brain neurotransmitter, Bankskota and Khan [28] suggest that 5-hydroxytryptamine (5-HT) is the common regulatory signal between many parts of the neuroimmune systems at the local and systemic levels. 5-HT may activate the HPA axis and alter the function of the gastrointestinal tract in people with depression or other psychiatric co-morbidities [29]. Others have reported a relationship, in people with IBD, between the autonomic nervous system, psychological adjustment [30] and inflammation [31].…”

Section: Pbm the Microbiome-gut-brain Axis And Hypothalamic-pituitary...mentioning

confidence: 99%

A Holistic Perspective on How Photobiomodulation May Influence Fatigue, Pain, and Depression in Inflammatory Bowel Disease: Beyond Molecular Mechanisms

Laakso

Ewais

2023

Biomedicines

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Background: Numerous mechanisms, mostly molecular, have been tested and proposed for photobiomodulation. Photobiomodulation is finding a niche in the treatment of conditions that have no gold-standard treatment or only partially effective pharmacological treatment. Many chronic conditions are characterised by symptoms for which there is no cure or control and for which pharmaceuticals may add to the disease burden through side effects. To add quality to life, alternate methods of symptom management need to be identified. Objective: To demonstrate how photobiomodulation, through its numerous mechanisms, may offer an adjunctive therapy in inflammatory bowel disease. Rather than considering only molecular mechanisms, we take an overarching biopsychosocial approach to propose how existing evidence gleaned from other studies may underpin a treatment strategy of potential benefit to people with Crohn’s disease and ulcerative colitis. Main findings: In this paper, the authors have proposed the perspective that photobiomodulation, through an integrated effect on the neuroimmune and microbiome–gut–brain axis, has the potential to be effective in managing the fatigue, pain, and depressive symptoms of people with inflammatory bowel disease.

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“…Lokesh et al highlighted the clinical significance of potential 5-HTR 4 agonists and antagonists for the treatment of depression and associated comorbidity in the gut. As 5-HTR 4 is expressed in the gut (in enterochromaffin cells and enteric neurons) and limbic system, the authors suggest the involvement of 5-HTR 4 in psychiatric diseases and gastrointestinal disorders, referring to the case of depression-induced IBS [49]. Moreover, the authors added that 5-HT can activate the HPA axis and alter gastrointestinal functions in patients with depression, leading to symptomatic IBS [34,49].…”

Section: Mediator In the Gut-brain Axismentioning

confidence: 99%

“…As 5-HTR 4 is expressed in the gut (in enterochromaffin cells and enteric neurons) and limbic system, the authors suggest the involvement of 5-HTR 4 in psychiatric diseases and gastrointestinal disorders, referring to the case of depression-induced IBS [49]. Moreover, the authors added that 5-HT can activate the HPA axis and alter gastrointestinal functions in patients with depression, leading to symptomatic IBS [34,49]. Recently, selective serotonin reuptake inhibitors (SSRIs) have been proposed as a possible common therapy for depression and IBD [50].…”

Section: Mediator In the Gut-brain Axismentioning

confidence: 99%

Gut-derived serotonin and its emerging roles in immune function, inflammation, metabolism and the gut–brain axis

Banskota

Khan

2022

Current Opinion in Endocrinology, Diabetes &Amp; Obesity

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Purpose of reviewTo shed light on the recently uncovered diverse role of serotonin (5-hydroxytryptamine; 5-HT) in the regulation of immune functions, inflammation, metabolism, and gut-brain axis. Recent findingsPeripheral 5-HT which accounts for approximately 95% of the total is largely synthesized in the gut by enterochromaffin cells. Enterochromaffin cells release 5-HT in response to various stimuli including microbial products. Released 5-HT influences secretomotor, sensory and immune functions as well as inflammatory processes in the gut. 5-HT released from enterochromaffin cells enters circulation and is taken up and concentrated in platelets. 5-HT released from the activated platelets interacts with different organs to alter their metabolic activity. 5-HT also serves as a link in the gut-brain axis.

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Therapeutic potential of serotonin 4 receptor for chronic depression and its associated comorbidity in the gut

Cited by 16 publications

References 227 publications

Effect of Short Photoperiod on Behavior and Brain Plasticity in Mice Differing in Predisposition to Catalepsy: The Role of BDNF and Serotonin System

Effect of Short Photoperiod on Behavior and Brain Plasticity in Mice Differing in Predisposition to Catalepsy: The Role of BDNF and Serotonin System

A Holistic Perspective on How Photobiomodulation May Influence Fatigue, Pain, and Depression in Inflammatory Bowel Disease: Beyond Molecular Mechanisms

Gut-derived serotonin and its emerging roles in immune function, inflammation, metabolism and the gut–brain axis

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