Therapeutic Potential of Selenium Nanoparticles

Majeed, Warda; Zafar, Maryam; Bhatti, Attya; Park, John

doi:10.4172/2157-7439.1000487

Cited by 18 publications

(15 citation statements)

References 46 publications

(52 reference statements)

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“…The results of the present study indicated that SeNPs are of beneficial effects on liver functions and restored the activities of ALT and AST toward normal levels as well as the level of albumin. These finding could be explained due to the radical scavenging property of Se and the importance of Se in protecting the integrity and the functions of tissues (Majeed et al 2018). These results could be due to the role of SeNPs in protecting the integrity and functions of liver tissues besides its radical scavenging activity.…”

Section: Discussionmentioning

confidence: 94%

“…Several studies have shown that SeNPs downregulate mRNA expression of pro-inflammatory cytokines including inducible NO synthase (iNOS), interleukin IL-1, and TNF-α thus reducing inflammation (Shi et al 2011;Wang et al 2016). Selenium is known as a fundamental component of selenoprotein, an essential enzyme in the body that protects against oxidative stress and inflammation (Majeed et al 2018).…”

Section: Discussionmentioning

confidence: 99%

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Mitigating effect of single or combined administration of nanoparticles of zinc oxide, chromium oxide, and selenium on genotoxicity and metabolic insult in fructose/streptozotocin diabetic rat model

Hassan

Elsayed

Kholief

et al. 2021

Environ Sci Pollut Res

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This research was intended to evaluate the antidiabetic effect of single or combined administration of nanoparticles of zinc oxide nanoparticles (ZnONPs), chromium oxide nanoparticles (Cr 2 O 3 NPs), and selenium nanoparticles (SeNPs), on genetic and metabolic insult in fructose/streptozotocin diabetic rat model. Type 2 diabetes mellitus was induced by feeding sixty adult male albino rats with a high fructose diet accompanied by a single i.p. injection of streptozotocin (STZ). The rats were divided into 6 groups (10 rats/each) and the doses of nanoparticles were 10 mg/kg b.wt for ZnONPs, 1 mg/kg b.wt for Cr 2 O 3 , and 0.4 mg/kg b.wt for SeNPs. The results displayed that diabetes significantly decreased bodyweight, serum insulin, C-peptide, adiponectin levels, erythrocyte glutathione peroxidase, serum superoxide dismutase activities, high-density lipoprotein cholesterol (HDL-C), and total antioxidant capacity while causing a substantial increase in serum glucose, C-reactive protein, atherogenic index, HOMA–IR, malondialdehyde, lipid profile, interleukin-6 levels, and liver function and kidney function parameters. Furthermore, the findings showed a decrease in insulin receptor substrate-1 (IRS-1) hepatic mRNA expression level and peroxisome proliferator-activated receptor (PPAR-γ) adipocyte mRNA expression level in type 2 diabetic rats. DNA damage was confirmed by performing the comet assay. Moreover, histological observation of pancreatic and hepatic tissues was performed, which were consistent with the biochemical results. The present study confirmed that oral administration of ZnONPs, Cr 2 O 3 NPs, SeNPs, and their mixture improved all the biochemical and genetic parameters toward normal levels and ameliorated the diabetic consequences that were manifested by restricting cellular DNA damage which maintaining pancreatic and hepatic tissues from oxidative damage. The best reported antidiabetic effect was observed in the mixture administered group.

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Mitigating effect of single or combined administration of nanoparticles of zinc oxide, chromium oxide, and selenium on genotoxicity and metabolic insult in fructose/streptozotocin diabetic rat model

Hassan

Elsayed

Kholief

et al. 2021

Environ Sci Pollut Res

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“…It has been reported that Se supplementation improves the condition of patients as well as reduces inflammation levels in experimental models, such as the granuloma pouch exudate, and in lupus mice or in the adjuvant arthritis in rats [ 41 ]. Evidence has suggested that Se can decrease inflammation in autoimmune disorders [ 42 ]. One report revealed that Se supplementation has an antioxidant effect as it upregulates selenoproteins and downregulates inflammation in autoimmune disorders [ 43 ].…”

Section: Serum Selenium Status In Rheumatoid Arthritismentioning

confidence: 99%

Biogenic Selenium Nanoparticles: Potential Solution to Oxidative Stress Mediated Inflammation in Rheumatoid Arthritis and Associated Complications

2021

Self Cite

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Rheumatoid arthritis (RA) is a common chronic inflammation-mediated disorder having systematic complications. RA triggers a self-directed inflammatory and immunological cascade that culminates in joint destruction. Though a range of treatment options are available, none of them are without adverse effects and this has led researchers to search for alternative solutions. Nanomedicine has emerged as a powerful therapeutic alternative, and selenium (Se) is an essential micronutrient trace element that has a crucial role in human health and disease. Selenium nanoparticles (SeNPs) derived from biological sources, such as plants, bacteria, fungi, and proteins, have exhibited remarkable candidate properties and toxicological profiles, and hence have shown potential to be used as antirheumatic agents. The potential of SeNPs can be attributed to the effect of functional groups bound to them, concentration, and most importantly to their nano range size. The antirheumatic effect of SeNPs is considerable due to its potential in amelioration of oxidative stress-mediated inflammation via downregulation of radical and nonradical species, markers of inflammation, and upregulation of inherent antioxidant defenses. The size and concentration impact of SeNPs has been shown in the subsequent antioxidant and anti-inflammatory properties. Moreover, the article emphasizes the role of these biogenic SeNPs as a notable option in the nanomedicine arena that needs to be further studied as a prospective remedial alternative to cure RA and medication-related adverse events.

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“…SeNPs can be synthesized via physical techniques such as UV radiation and laser ablation; chemically via acid decomposition, catalytic reductions, and precipitation, biologically via microorganisms or plant extracts [11]. The health benefi ts of SeNPs are anti-aging, antioxidant, antidiabetic, boost immunity, reduces infl ammation, improves fertility and brain functions, anti-asthma, anti-arthritic, treats muscular dystrophy, antiviral, and regulates thyroid [12].…”

Section: Introductionmentioning

confidence: 99%

Selenium nanoparticles: Small is the new big: Mini review

Jolly¹,

Rauf²,

Ahmad³

2020

Open Journal of Chemistry

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Nanotechnology is the study of developing peculiar particles (1-100 nanometres (nm)) of matter at an atomic, molecular, and supramolecular scale. These nanoparticles possess unique properties such as large surface area, fewer side effects, bioavailability, decrease the toxicity, and prolonged drug release. Some inorganic metals nanoparticles like Ti, Se, Zn, Ag, Ce, Au, and Fe play possess antonymous bioactivities. Selenium is the essential trace element and essential micronutrient in the biological system. There are 25 selenoproteins in the human body possessing oxidoreductase activity; therefore, regulating the physiological redox balance in the organs system. Selenium nanoparticles (SeNPs) have exclusive properties and bioactivities as compared to traditional selenium supplements. Therefore, SeNPs have been attracted worldwide interest as a therapeutic agent and food additive. In this review, we have discussed the therapeutics applications of selenium nanoparticles.

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Therapeutic Potential of Selenium Nanoparticles

Abstract: Nanomedicine & Nanotechnology J o ur nal of N a n o m ed icine & N a n o te chnolo g y

Cited by 18 publications

References 46 publications

Mitigating effect of single or combined administration of nanoparticles of zinc oxide, chromium oxide, and selenium on genotoxicity and metabolic insult in fructose/streptozotocin diabetic rat model

Mitigating effect of single or combined administration of nanoparticles of zinc oxide, chromium oxide, and selenium on genotoxicity and metabolic insult in fructose/streptozotocin diabetic rat model

Biogenic Selenium Nanoparticles: Potential Solution to Oxidative Stress Mediated Inflammation in Rheumatoid Arthritis and Associated Complications

Selenium nanoparticles: Small is the new big: Mini review

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