Therapeutic Potential of Selenium Compounds in the Treatment of Cancer

Selvam, Arun Kumar; Björnstedt, Mikael; Misra, Santosh

doi:10.1007/978-3-319-95390-8_13

Cited by 1 publication

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“…Although it is not considered an active drug, it has been well-established that its metabolites, such as methylselenol and MSP, display antitumoral and antiproliferative properties [188]. The significant role of methylselenol in antitumoral treatment lies in its capacity to induce cell death and it is recognized as one of the most cytotoxic Se compounds [23, 72,188,190,191]. Likewise, MSP also exhibits interesting properties, such as its ability to inhibit angiogenesis and histone deacetylase (HDAC) [72,192,193].…”

Section: Se-methylselenocysteine and Cancermentioning

confidence: 99%

Seleno-Metabolites and Their Precursors: A New Dawn for Several Illnesses?

et al. 2022

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Selenium (Se) is an essential element for human health as it is involved in different physiological functions. Moreover, a great number of Se compounds can be considered potential agents in the prevention and treatment of some diseases. It is widely recognized that Se activity is related to multiple factors, such as its chemical form, dose, and its metabolism. The understanding of its complex biochemistry is necessary as it has been demonstrated that the metabolites of the Se molecules used to be the ones that exert the biological activity. Therefore, the aim of this review is to summarize the recent information about its most remarkable metabolites of acknowledged biological effects: hydrogen selenide (HSe−/H2Se) and methylselenol (CH3SeH). In addition, special attention is paid to the main seleno-containing precursors of these derivatives and their role in different pathologies.

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