Therapeutic Potential of Select Dietary Compounds in the Management of Hypertension and its Cardiovascular Complications

Valookaran, Aleena Francis; Bouchard, Jenny; Aloud, Basma Milad; Thandapilly, Sijo Joseph; Netticadan, Thomas

doi:10.3390/molecules27217222

Cited by 5 publications

(3 citation statements)

References 188 publications

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“…It is well recognized that oxidative stress in the central areas is crucial for maintaining cardiovascular control. In hypertensive rats, quercetin could reduce oxidative stress levels in the heart, lungs, liver, and kidneys (Valookaran et al, 2022). Quercetin can also inhibit the generation of free radicals and increase the expression of ERK, PPARγ (Zhao, Wang, et al, 2021).…”

Section: Quercetin In the Treatment Of Oxidative Stress‐related Diseasesmentioning

confidence: 99%

Advance in the pharmacological effects of quercetin in modulating oxidative stress and inflammation related disorders

Zhou

Qian

Tang

et al. 2023

Phytotherapy Research

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Numerous pharmacological effects of quercetin have been illustrated, including antiinflammation, antioxidation, and anticancer properties. In recent years, the antioxidant activity of quercetin has been extensively reported, in particular, its impacts on glutathione, enzyme activity, signaling transduction pathways, and reactive oxygen species (ROS). Quercetin has also been demonstrated to exert a striking antiinflammatory effect mainly by inhibiting the production of cytokines, reducing the expression of cyclooxygenase and lipoxygenase, and preserving the integrity of mast cells. By regulating oxidative stress and inflammation, which are regarded as two critical processes involved in the defense and regular physiological operation of biological systems, quercetin has been validated to be effective in treating a variety of disorders. Symptoms of these reactions have been linked to degenerative processes and metabolic disorders, including metabolic syndrome, cardiovascular, neurodegeneration, cancer, and nonalcoholic fatty liver disease. Despite that evidence demonstrates that antioxidants are employed to prevent excessive oxidative and inflammatory processes, there are still concerns regarding the expense, accessibility, and side effects of agents. Notably, natural products, especially those derived from plants, are widely accessible, affordable, and generally safe. In this review, the antioxidant and antiinflammatory abilities of the active ingredient quercetin and its application in oxidative stress‐related disorders have been outlined in detail.

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Section: Quercetin In the Treatment Of Oxidative Stress‐related Diseasesmentioning

confidence: 99%

Advance in the pharmacological effects of quercetin in modulating oxidative stress and inflammation related disorders

Zhou

Qian

Tang

et al. 2023

Phytotherapy Research

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“…Primary hypertension is a risk factor for and a contributor to various diseases. These include cardiovascular ailments like stroke, coronary artery disease, heart failure, peripheral vascular disease, and conditions like renal disease and hypertensive retinopathy [1,[5][6][7] . Hypertensive retinopathy typically advances subtly, often devoid of symptoms, but in severe cases, it can lead to reduced vision, eye swelling, and even double vision [7] .…”

Section: Introductionmentioning

confidence: 99%

Dry eye rate and its relationship with disease stage in patients with primary hypertension: a cross-sectional study in Vietnam

Thang,

Huynh,

Kien

et al. 2024

Int J Ophthalmol

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AIM: To determine the dry eye (DE) rate and its relationship with disease stage in patients with primary hypertension. METHODS: A cross-sectional study included 432 patients with primary hypertension (with an equal number of patients in each group: 144 in stage I, II, and III hypertension) and 144 healthy subjects as a control group. The Ocular Surface Disease Index (OSDI) and Schirmer I test without anesthetics were conducted on all 576 subjects. Subjects with OSDI scores <13 and Schirmer I values equal to or under 10 mm were diagnosed with DE. RESULTS: The ratio of DE in hypertension patients was higher than in the control group (41.7% versus 18.8%; P<0.001). The proportion of patients with DE increased gradually according to the hypertension stage: 27.1% in stage I, 40.3% in stage II, and 57.6% in stage III, P<0.001. Age, duration of hypertension, plasma urea, creatinine, and high-sensitivity C-reactive protein (CRP-hs) levels in hypertension patients with DE were higher than those without DE, P<0.001. Advanced age, a long duration of hypertension, diabetes mellitus, elevated plasma creatinine, and CRP-hs levels were independent factors associated with DE in primary hypertension patients, P<0.001. CONCLUSION: DE is a common disorder associated with advanced age, a long duration of hypertension, diabetes mellitus, elevated plasma CRP-hs, and creatinine levels in patients with primary hypertension.

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“…Shift work, short sleep duration or poor sleep, and other forms of circadian disruption might increase the risk of hypertension [9]. Bioactive compounds that occur in small quantities in foods such as onions, fish, and red wine are being intensively studied to uncover their vasoprotective, antioxidant, antiproliferative, and anti-inflammatory effects which are beneficial to attenuate chronic disease and protect human health [10].…”

Section: Introductionmentioning

confidence: 99%

A Literature Review: Effectiveness of Swedish Foot Massage Therapy on Quality of Sleep in Elderly with Essential Hypertension

Widyaningrum,

Ulum,

Yulianti

2023

Dis.Prev.Public Heal J.

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Background: Aging processes in the elderly lead to degenerative diseases, one of them being essential hypertension. The elderly with hypertension often complain about sleeping problems, difficulty staying awake, often waking up in the middle of the night, and later difficulty going back to sleep, waking up too early, and sleeping poorly. Treatment of sleeping problems may include pharmacology and non-pharmacology. One nonpharmacological treatment was a complementary therapy called foot massage with Swedish techniques. The purpose is to determine the effect of Swedish foot massage therapy on sleep quality in the elderly with essential hypertension. Method: Literature Review. Data Sources: Science Direct, Springer Nature, Hindawi, Researchgate, and Sinta. The research method used is Literature Review with the PICO Analyst method (Problem, Intervention, Comparison, and Outcome) from 2011 to 2021 with the keywords "Swedish foot massage" AND "sleep quality" AND "hypertension". Based on the purpose of this study, the researcher reviewed 256 articles, and 251 were excluded. Results: Based on the results of the analysis of 5 journals, the duration of the research intervention varies widely, ranging from 2 days to 1 month. The average frequency of an intervention is 1-2 times a day. The duration of each meeting ranges from 20-40 minutes. Conclusions: Based on the results of the analysis of 5 journals, the intervention of Swedish foot massage therapy significantly improves the sleep quality of hypertensive patients. The researchers recommend Swedish foot massage therapy to improve the quality of sleep for people with essential hypertension.

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Therapeutic Potential of Select Dietary Compounds in the Management of Hypertension and its Cardiovascular Complications

Cited by 5 publications

References 188 publications

Advance in the pharmacological effects of quercetin in modulating oxidative stress and inflammation related disorders

Advance in the pharmacological effects of quercetin in modulating oxidative stress and inflammation related disorders

Dry eye rate and its relationship with disease stage in patients with primary hypertension: a cross-sectional study in Vietnam

A Literature Review: Effectiveness of Swedish Foot Massage Therapy on Quality of Sleep in Elderly with Essential Hypertension

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