Therapeutic Potential of Polymer-Coated Mesoporous Silica Nanoparticles

Bansal, Kuldeep K.; Mishra, Deepakkumar; Rosling, Ari; Rosenholm, Jessica M.

doi:10.3390/app10010289

Cited by 28 publications

(18 citation statements)

References 84 publications

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“…Among the existing cationic polymers, PEI is the most commonly used and is generally accepted as the gold standard for nonviral gene delivery [ 15 , 64 ]. This polymer has a high density of amine groups which, not only enhance the electrostatic interaction with genetic material and the cellular uptake but also help to avoid the endo/lysosomal pathway degradation due to the “proton sponge effect” [ 64 , 69 ].…”

Section: Hybrid Silica Nanoparticlesmentioning

confidence: 99%

Silica-Based Gene Delivery Systems: From Design to Therapeutic Applications

2020

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Advances in gene therapy have been foreshadowing its potential for the treatment of a vast range of diseases involving genetic malfunctioning. However, its therapeutic efficiency and successful outcome are highly dependent on the development of the ideal gene delivery system. On that matter, silica-based vectors have diverted some attention from viral and other types of non-viral vectors due to their increased safety, easily modifiable structure and surface, high stability, and cost-effectiveness. The versatility of silane chemistry and the combination of silica with other materials, such as polymers, lipids, or inorganic particles, has resulted in the development of carriers with great loading capacities, ability to effectively protect and bind genetic material, targeted delivery, and stimuli-responsive release of cargos. Promising results have been obtained both in vitro and in vivo using these nanosystems as multifunctional platforms in different potential therapeutic areas, such as cancer or brain therapies, sometimes combined with imaging functions. Herein, the current advances in silica-based systems designed for gene therapy are reviewed, including their main properties, fabrication methods, surface modifications, and potential therapeutic applications.

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Section: Hybrid Silica Nanoparticlesmentioning

confidence: 99%

Silica-Based Gene Delivery Systems: From Design to Therapeutic Applications

2020

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“…For the purpose of drug carrier, MSNs are frequently functionalized with polymer as it has a higher probability to improve the overall performance and therapeutic effect of the carrier [ 81 ]. The class of polymer to be functionalized on MSNs will be based on the desired outcome such as biocompatibility, specific targeting, stimuli-responsive or sustained release of drugs from the MSNs [ 82 ]. However, in this section, we will be focusing on the polymer functionalized MSNs, while the purpose of polymer functionalization will be further explained in the upcoming sections.…”

Section: Fabrication Of Msnsmentioning

confidence: 99%

Progress in Mesoporous Silica Nanoparticles as Drug Delivery Agents for Cancer Treatment

et al. 2021

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Cancer treatment and therapy have made significant leaps and bounds in these past decades. However, there are still cases where surgical removal is impossible, metastases are challenging, and chemotherapy and radiotherapy pose severe side effects. Therefore, a need to find more effective and specific treatments still exists. One way is through the utilization of drug delivery agents (DDA) based on nanomaterials. In 2001, mesoporous silica nanoparticles (MSNs) were first used as DDA and have gained considerable attention in this field. The popularity of MSNs is due to their unique properties such as tunable particle and pore size, high surface area and pore volume, easy functionalization and surface modification, high stability and their capability to efficiently entrap cargo molecules. This review describes the latest advancement of MSNs as DDA for cancer treatment. We focus on the fabrication of MSNs, the challenges in DDA development and how MSNs address the problems through the development of smart DDA using MSNs. Besides that, MSNs have also been applied as a multifunctional DDA where they can serve in both the diagnostic and treatment of cancer. Overall, we argue MSNs provide a bright future for both the diagnosis and treatment of cancer.

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“…One of the main requirements for a DDS is to be stable in blood without releasing the drug prematurely. This feature can be introduced into the design of the nano-vehicle by using polymers [ 50 ]. Furthermore, polymers are well known materials to prepare stealth nanoparticles, which allows evading immune recognition to enhance its circulation time in vivo.…”

Section: Multiple Drug Delivery Systems Based On Msnsmentioning

confidence: 99%

“…The external layer of the polymeric coating of MSNs [ 50 ] can be decorated with a variety of ligands for targeted delivery [ 80 ]. In the context of dual delivery, four types of targeting have been implemented in the DDSs: Folic acid, hyaluronic acid (HA), lactobionic acid (LA), and peptides such as TAT.…”

Section: Nano-systems Based On Msns For the Delivery Of Combinatiomentioning

confidence: 99%

Preparation and Applications of Organo-Silica Hybrid Mesoporous Silica Nanoparticles for the Co-Delivery of Drugs and Nucleic Acids

et al. 2020

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Combination therapies rely on the administration of more than one drug, with independent mechanisms of action, aiming to enhance the efficiency of the treatment. For an optimal performance, the implementation of such therapies requires the delivery of the correct combination of drugs to a specific cellular target. In this context, the use of nanoparticles (NP) as platforms for the co-delivery of multiple drugs is considered a highly promising strategy. In particular, mesoporous silica nanoparticles (MSN) have emerged as versatile building blocks to devise complex drug delivery systems (DDS). This review describes the design, synthesis, and application of MSNs to the delivery of multiple drugs including nucleic acids for combination therapies.

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Therapeutic Potential of Polymer-Coated Mesoporous Silica Nanoparticles

Cited by 28 publications

References 84 publications

Silica-Based Gene Delivery Systems: From Design to Therapeutic Applications

Silica-Based Gene Delivery Systems: From Design to Therapeutic Applications

Progress in Mesoporous Silica Nanoparticles as Drug Delivery Agents for Cancer Treatment

Preparation and Applications of Organo-Silica Hybrid Mesoporous Silica Nanoparticles for the Co-Delivery of Drugs and Nucleic Acids

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