Therapeutic Potential of Optogenetic Treatment for Individuals with Multiple Sclerosis

Koussy, Mohamed M El; Jadavji, Nafisa M.

doi:10.22186/jyi.33.4.77-82

Cited by 2 publications

(3 citation statements)

References 29 publications

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“…(Ordaz et al, 2017, Gibson et al, 2014 Research also suggests that Oligodendrocyte precursor cells (OPCs) could be optogenetically modulated to tackle MS, furthermore, astrocytes expressing ChR2 could be stimulated with light to reduce inflammation and increase the protection of neurons. (Koussy & Jadavji, 2017)…”

Section: Multiple Sclerosismentioning

confidence: 99%

Neurodegenerative Disorders Through the Lens of Optogenetics

2023

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Neurodegenerative disorder, as the name suggests, encompasses progressive neuronal degeneration that renders patients with a lack of, or at the very least dysfunctional cognition, motor senses, and bodily functions. The progressive worsening of the condition in conjugation with the lack of therapeutic measures makes them very difficult to bear. Optogenetics, as discussed below, offers an approach that has contributed to the research for a solution to neurological degeneration at two fronts. The tools in the disciple help us employ microbial opsins to gain pinpoint control over neuronal firing. Furthermore, the engagements after an inhibitory or stimulatory control have been gained over neural circuitry have been insightful in understanding the progression of neurological pathologies. The following review will delve into the therapies available for Alzheimer's Disease, Amyotrophic lateral sclerosis (ALS), Huntington's Disease, Multiple sclerosis (MS), and Parkinson's Disease and explore the research insights. Keywords: Optogenetics, Neurodegenerative disorders, Alzheimer’s Disease, Parkinson’s Disease, Multiple Sclerosis, Amyotrophic Lateral Sclerosis, Huntington’s Chorea

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Section: Multiple Sclerosismentioning

confidence: 99%

Neurodegenerative Disorders Through the Lens of Optogenetics

2023

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“…Related information about the therapeutic potential of photostimulation in the treatment of MS-related symptoms can be found in the review coordinated by El Koussy and Jadavji. 49…”

Section: Msmentioning

confidence: 99%

“…Moreover, it has been shown that optogenetics can be effective in attenuating MS‐associated signs and symptoms like tremors, 45 visual learning and memory impairment, 46 visual dysfunction, 47 and bladder and bowel impairment 48 by controlling specific pathways involved in them. Related information about the therapeutic potential of photostimulation in the treatment of MS‐related symptoms can be found in the review coordinated by El Koussy and Jadavji 49 …”

Section: Neurobiologymentioning

confidence: 99%

The state of the art of biomedical applications of optogenetics

Neghab

Soheilifar²,

Grusch

et al. 2021

Lasers Surg Med

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Background and objective Optogenetics has opened new insights into biomedical research with the ability to manipulate and control cellular activity using light in combination with genetically engineered photosensitive proteins. By stimulating with light, this method provides high spatiotemporal and high specificity resolution, which is in contrast to conventional pharmacological or electrical stimulation. Optogenetics was initially introduced to control neural activities but was gradually extended to other biomedical fields. Study design In this paper, firstly, we summarize the current optogenetic tools stimulated by different light sources, including lasers, light‐emitting diodes, and laser diodes. Second, we outline the variety of biomedical applications of optogenetics not only for neuronal circuits but also for various kinds of cells and tissues from cardiomyocytes to ganglion cells. Furthermore, we highlight the potential of this technique for treating neurological disorders, cardiac arrhythmia, visual impairment, hearing loss, and urinary bladder diseases as well as clarify the mechanisms underlying cancer progression and control of stem cell differentiation. Conclusion We sought to summarize the various types of promising applications of optogenetics to treat a broad spectrum of disorders. It is conceivable to expect that optogenetics profits a growing number of patients suffering from a range of different diseases in the near future.

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Therapeutic Potential of Optogenetic Treatment for Individuals with Multiple Sclerosis

Cited by 2 publications

References 29 publications

Neurodegenerative Disorders Through the Lens of Optogenetics

Neurodegenerative Disorders Through the Lens of Optogenetics

The state of the art of biomedical applications of optogenetics

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