Therapeutic Potential of Niche-Specific Mesenchymal Stromal Cells for Spinal Cord Injury Repair

Lindsay, Susan L.; Barnett, Susan C.

doi:10.3390/cells10040901

Cited by 21 publications

(20 citation statements)

References 145 publications

(96 reference statements)

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“…And numerous studies have showed that these pluripotent stem cells can effectively correct various functional parameters of the SCI models ( Figure 2 ) ( 9 ). In investigating the underlying mechanisms involved, it was found that MSCs exert their therapeutic effects mainly through the cell-cell interactions and the secretion of various cytokines to suppress the inflammatory response ( 75 ).…”

Section: Role Of Mscs On Inflammatory Responsementioning

confidence: 99%

Neuroinflammation and Scarring After Spinal Cord Injury: Therapeutic Roles of MSCs on Inflammation and Glial Scar

Pang

Chen

et al. 2021

Front. Immunol.

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Transected axons are unable to regenerate after spinal cord injury (SCI). Glial scar is thought to be responsible for this failure. Regulating the formation of glial scar post-SCI may contribute to axonal regrow. Over the past few decades, studies have found that the interaction between immune cells at the damaged site results in a robust and persistent inflammatory response. Current therapy strategies focus primarily on the inhibition of subacute and chronic neuroinflammation after the acute inflammatory response was executed. Growing evidences have documented that mesenchymal stem cells (MSCs) engraftment can be served as a promising cell therapy for SCI. Numerous studies have shown that MSCs transplantation can inhibit the excessive glial scar formation as well as inflammatory response, thereby facilitating the anatomical and functional recovery. Here, we will review the effects of inflammatory response and glial scar formation in spinal cord injury and repair. The role of MSCs in regulating neuroinflammation and glial scar formation after SCI will be reviewed as well.

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Section: Role Of Mscs On Inflammatory Responsementioning

confidence: 99%

Neuroinflammation and Scarring After Spinal Cord Injury: Therapeutic Roles of MSCs on Inflammation and Glial Scar

Pang

Chen

et al. 2021

Front. Immunol.

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“…Many different types of human adult-tissue-derived MSCs have been shown to have therapeutic potential in the EAE model, although there has been large variability in the efficacy between cell types [ 7 , 35 – 39 ]. Tissue-specific stem cells support the tissue from which they originate, suggesting that certain MSC types might be more suitable for the treatment of EAE [ 40 ]. hOM-MSCs reside in a neurogenic niche vulnerable to physical and chemical injury that can undergo continuous cell replacement after injury.…”

Section: Discussionmentioning

confidence: 99%

“…The entire hOM-MSC population highly express nestin, while hBM-MSCs express substantially less (approximately 50%) [ 42 ]; typically expressed in those hBM-MSCs associated with adrenergic nerve fibres [ 43 ]. This may reflect functional differences since nestin + MSCs are considered to have a neurosupportive role, making them more suitable for MS repair [ 21 , 40 ]. hOM-MSCs have also been shown to secrete lower levels of the inflammatory cytokines IL-6, IL-8 and CCL2 constitutively when compared to hBM-MSCs and their CM can skew microglia to an anti-inflammatory phenotype [ 15 ].…”

Section: Discussionmentioning

confidence: 99%

Human olfactory mesenchymal stromal cell transplantation ameliorates experimental autoimmune encephalomyelitis revealing an inhibitory role for IL16 on myelination

Lindsay

Molęda

MacLellan

et al. 2022

acta neuropathol commun

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One of the therapeutic approaches for the treatment of the autoimmune demyelinating disease, multiple sclerosis (MS) is bone marrow mesenchymal stromal cell (hBM-MSCs) transplantation. However, given their capacity to enhance myelination in vitro, we hypothesised that human olfactory mucosa-derived MSCs (hOM-MSCs) may possess additional properties suitable for CNS repair. Herein, we have examined the efficacy of hOM-MSCs versus hBM-MSCs using the experimental autoimmune encephalomyelitis (EAE) model. Both MSC types ameliorated disease, if delivered during the initial onset of symptomatic disease. Yet, only hOM-MSCs improved disease outcome if administered during established disease when animals had severe neurological deficits. Histological analysis of spinal cord lesions revealed hOM-MSC transplantation reduced blood–brain barrier disruption and inflammatory cell recruitment and enhanced axonal survival. At early time points post-hOM-MSC treatment, animals had reduced levels of circulating IL-16, which was reflected in both the ability of immune cells to secrete IL-16 and the level of IL-16 in spinal cord inflammatory lesions. Further in vitro investigation revealed an inhibitory role for IL-16 on oligodendrocyte differentiation and myelination. Moreover, the availability of bioactive IL-16 after demyelination was reduced in the presence of hOM-MSCs. Combined, our data suggests that human hOM-MSCs may have therapeutic benefit in the treatment of MS via an IL-16-mediated pathway, especially if administered during active demyelination and inflammation.

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“…Scientists proposed that these results might be largely explained by their paracrine effects or direct interactions with immune cells. 125 …”

Section: Contribution Of Mscs Transplantation To Sci Prognosismentioning

confidence: 99%

Regulatory Role of Mesenchymal Stem Cells on Secondary Inflammation in Spinal Cord Injury

QM¹,

Sy²,

SP³

et al. 2022

JIR

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Spinal cord injury (SCI) is a catastrophic condition with high morbidity and mortality that still lacks effective therapeutic strategies. It is well known that the most important stage in SCI pathogenesis is secondary injury, and among the involved mechanisms, the inflammatory cascade is the main contributor and directly influences neurological function recovery. In recent years, increasing evidence has shown that mesenchymal stem cells (MSCs) transplantation is a promising immunomodulatory strategy. Transplanted MSCs can regulate macrophage-, astrocyte-, and T lymphocyte-mediated neuroinflammation and help create a microenvironment that facilitates tissue repair and regeneration. This review focuses on the effects of different types of immune cells and MSCs, specifically the immunoregulatory capacity of MSCs in SCI and repair. We will also discuss how to exploit MSCs transplantation to regulate immune cells and develop novel therapeutic strategies for SCI.

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Therapeutic Potential of Niche-Specific Mesenchymal Stromal Cells for Spinal Cord Injury Repair

Cited by 21 publications

References 145 publications

Neuroinflammation and Scarring After Spinal Cord Injury: Therapeutic Roles of MSCs on Inflammation and Glial Scar

Neuroinflammation and Scarring After Spinal Cord Injury: Therapeutic Roles of MSCs on Inflammation and Glial Scar

Human olfactory mesenchymal stromal cell transplantation ameliorates experimental autoimmune encephalomyelitis revealing an inhibitory role for IL16 on myelination

Regulatory Role of Mesenchymal Stem Cells on Secondary Inflammation in Spinal Cord Injury

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