Therapeutic potential of nanotechnology in reproduction disorders and possible limitations

Abstract

Summary One of the prominent peculiarities of nanoparticles (NPs) is their ability to cross biological barriers. Therefore, the development of NPs with different properties has great therapeutic potential in the area of reproduction because the association of drugs, hormones and other compounds with NPs represents an alternative for delivering substances directly at a specific site and for treatment of reproductive problems. Additionally, lipid-based NPs can be taken up by the tissues of patients with ovarian failure, deep endometriosis, testicular dysfunctions, etc., opening up new perspectives for the treatment of these diseases. The development of nanomaterials with specific size, shape, ligand density and charge certainly will contribute to the next generation of therapies to solve fertility problems in humans. Therefore, this review discusses the potential of NPs to treat reproductive disorders, as well as to regulate the levels of the associated hormones. The possible limitations of the clinical use of NPs are also highlighted.

Recent Advances in Nanotechnology-Based Drug Delivery Systems for the Diagnosis and Treatment of Reproductive Disorders

“…Additionally, ongoing research is exploring the use of nanomaterials for diagnostic purposes, such as imaging and sensing techniques, further expanding their potential in the field of medicine . Nanotechnology holds promise to treat many chronic diseases, which include cardiovascular, neurological, gastrointestinal, autoimmune inflammatory, infectious, and reproductive diseases, as well as various types of cancer …”

“…Additionally, ongoing research is exploring the use of nanomaterials for diagnostic purposes, such as imaging and sensing techniques, 7 further expanding their potential in the field of medicine. 8 Nanotechnology holds promise to treat many chronic diseases, which include cardiovascular, 9 neurological, 10 gastrointestinal, 11 autoimmune inflammatory, 12 infectious, 13 and reproductive diseases, 14 as well as various types of cancer. 15 With the help of nanoscience, reproductive assistive technology has revolutionized the field of fertility treatments, and scientists have been able to develop innovative methods that improve the success rates of procedures such as in vitro fertilization (IVF) and sperm selection by utilizing nano-technology.…”