Therapeutic potential of mesenchymal stem cells for diabetes

Abstract

Mesenchymal stem cells (MSCs) are self-renewing multipotent cells that have the capacity to secrete multiple biologic factors that can restore and repair injured tissues. Preclinical and clinical evidence have substantiated the therapeutic benefit of MSCs in various medical conditions. Currently, MSCs are the most commonly used cell-based therapy in clinical trials because of their regenerative effects, ease of isolation, and low immunogenicity. Experimental and clinical studies have provided promising results using MSCs to treat diabetes. This review will summarize the role of MSCs on tissue repair, provide emerging strategies to improve MSC function, and describe how these processes translate to clinical treatments for diabetes.

Interaction of Human Mesenchymal Stem Cells with Soft Nanocomposite Hydrogels Based on Polyethylene Glycol and Dendritic Polyglycerol

“…hMSCs are now being investigated in many applications in regenerative medicine, tissue engineering, and cell‐based therapy. It is important to keep the stemness of the cells since a lower expression of the markers would decrease the efficiency of therapies . In line with immunophenotyping, mechanosensing ability is also a valued quality …”

Effects of mesenchymal stromal cells on motor function and collagen in the skeletal muscles of rats with type I diabetes

“…The present therapeutic options have not been successful in preventing the long‐term complications triggered by T1D, stimulating the search for alternative approaches such as the use of stem cells . Mesenchymal stromal cells (MSCs) can be defined by their ability to differentiate into a variety of mesenchymal tissue types (adipose tissue, cartilage and bone) .…”

“…Mesenchymal stromal cells (MSCs) can be defined by their ability to differentiate into a variety of mesenchymal tissue types (adipose tissue, cartilage and bone) . In addition, the use of MSCs is an attractive therapeutic strategy that is able to modify the microenvironment of injured tissues contributing to tissue repair and regeneration, as well as improving the metabolic profile in various animal models of diabetes . There is little evidence regarding the effects of MSCs on muscular dysfunction caused by DM.…”

“…The present therapeutic options have not been successful in preventing the long-term complications triggered by T1D, stimulating the search for alternative approaches such as the use of stem cells. 16 Mesenchymal stromal cells (MSCs) can be defined by their ability to differentiate into a variety of mesenchymal tissue types (adipose tissue, cartilage and bone). 17,18 In addition, the use of MSCs is an attractive therapeutic strategy that is able to modify the microenvironment of injured tissues contributing to tissue repair and regeneration, 19 as well as improving the metabolic profile in various animal models of diabetes.…”

“…17,18 In addition, the use of MSCs is an attractive therapeutic strategy that is able to modify the microenvironment of injured tissues contributing to tissue repair and regeneration, 19 as well as improving the metabolic profile in various animal models of diabetes. 16,20,21 There is little evidence regarding the effects of MSCs on muscular dysfunction caused by DM. It was previously demonstrated that MSC transplantation improved walking performance and decreased muscle fibrosis in DM by modulating atrogenes.…”