Therapeutic Potential of Mesenchymal Stem Cells for Oral and Systemic Diseases

Revascularization and Treatment Methods

“…88 Fakat etik ve immünolojik nedenlerden dolayı allojenik kök hücre kullanımı sınırlanmıştır ve daha çok postnatal kök hücreler üzerine çalışmalar yoğunlaşmıştır. 89 Ancak postnatal kök hücreler progenitör ve yüksek diferansiyasyon özelliğine sahip değildir. Aynı zamanda bu hücreler kendini replike etme özelliğine de sahip değildir.…”

Odontogenic epithelial stem cells: hidden sources

“…3,9,[13][14][15][16][17] Many reports have described the multi-potentiality and possible applications of mesenchymal DSCs in dental and non-dental tissue regeneration. [18][19][20][21][22][23] [18][19][20][21][22][23][24] Their uniqueness of development from CNCCs explains their multilineage differentiation characteristics.…”

“…68 The regeneration of non-dental tissues of critical value, such as the cornea, cardiac cells, neurons, pancreatic islets, and retina, from oral and DSCs will have favorable results in the near future because of their embryonic origin. [18][19][20][21][22][23]43 The current treatment protocols for dental defects by either the fillings with biocompatible materials or the tooth replacement with dental implants are well established with standard techniques, which are economically affordable and ethically safe. Clinical studies on human dental tissue regeneration should target acceptable and easy procedures for application in regenerative medicine with nano-structured materials as reported by Mitsiadis et al 69 and Mitsiadis and Papagerakis.…”

Transforming Growth Factor-ß1 (TGF-ß1) immunoreactivity in heterotopic grafts of adult dental apical papilla.

“…The progenitors of these cells come from the neural crest and colonize the dental papilla during odontogenesis 2 . The potential of these ectomesenchymal stem cells opens a range of therapeutic treatments in advanced restorative dentistry, for which the autologous or allogeneic transplant of these cells would allow for the regeneration of adult dental and periodontal tissues [3][4][5][6] .…”

“…Stem Cells of dental origin are used in the search of new therapeutic approaches with the aim of promoting tissue regeneration in the case of loss of pulpal and dentinal tissues [3][4][5][6]15 .…”