Therapeutic Potential of Menstrual Blood-Derived Stem Cell Transplantation for Intrauterine Adhesions

Abstract

An increasing number of women experience intrauterine adhesion as a result of intrauterine operations, such as induced abortion, which can cause infertility, recurrent abortion and amenorrhea. Although some strategies have been applied clinically, such as hysteroscopy adhesiolysis of intrauterine adhesions, the results have not been promising. As regenerative medicine develops, research on menstrual blood-derived stem cell transplantation is increasing due to the properties of these cells, including self-renewal, differentiation, angiogenesis, anti-inflammation and immunomodulation. As a result, menstrual blood-derived stem cells may be an ideal cell source for the treatment of intrauterine adhesion. Excitingly, it has been reported that autologous menstrual blood stem cells could recovery injured endometrium and improve infertility in patients with refractory intrauterine adhesion. In this review, we discuss the possible potential of menstrual blood-derived stem cell transplantation for intrauterine adhesion, including the antifibrosis, angiogenesis, anti-inflammation and immunoregulation properties of the cells, which brings hopes for clinical therapy.

Supplementation of mitochondria from endometrial mesenchymal stem cells improves oocyte quality in aged mice

“… 19 Endometrial mesenchymal stem cells (EnMSCs) are located in the endometrium and can be extracted from menstrual blood and used to treat diseases such as intrauterine adhesions. 20 In this study, we demonstrated that purified EnMSCs can be stably cultured with relatively superior mitochondrial function compared to that of primary endometrial stromal cells (ESCs) in a mouse model. We also found that the transfer of mitochondria from EnMSCs can improve oocyte quality and fertility in aged mice.…”

“…Studies in the past decade have shown that mitochondria from mesenchymal stem cells (MSCs) can regenerate and repair damaged cells or tissues 19 . Endometrial mesenchymal stem cells (EnMSCs) are located in the endometrium and can be extracted from menstrual blood and used to treat diseases such as intrauterine adhesions 20 . In this study, we demonstrated that purified EnMSCs can be stably cultured with relatively superior mitochondrial function compared to that of primary endometrial stromal cells (ESCs) in a mouse model.…”

The Concept behind the Suitability of Menstrual Blood-Derived Stem Cells for the Management of Vaginal Atrophy among BRCA Mutation Carriers after RRSO

“…Nevertheless, MenSC have already been extensively applied in preclinical studies and in some clinical research, with many of them revealing positive and successful outcomes in a variety of diseases. Gynecological applications of this novel therapy are summarized in Figure 2 [13,[37][38][39][40][41][42][43][44]. Some novel strategies for the use of MenSC in treatment have been comprehensively studied.…”

The Role of Endometrial Stem/Progenitor Cells in Recurrent Reproductive Failure

“…eSPCs have been found to play a crucial role in the regeneration and repair of the endometrium [ 54 , 126 , 127 ]. We therefore would envisage eSPCs to be involved in the persistent aberrations in the functionalis layer of each successive cycle, associated with the implantation process and subsequent pregnancy establishment in RRF.…”

“…The authors concluded that stem cells derived from menstrual blood may have a role in repairing the damaged endometrium, which could be due to the engagement of angiogenesis mediated by stem cells derived from menstrual blood [ 151 ]. Therapy with autologous eMSCs derived from menstrual blood has also shown promise, accelerating the healing process of damaged endometrium by inducing self-renewal, differentiation, angiogenesis, anti-inflammation, and immunomodulation [ 127 ]. Numerous issues must, however, be addressed before treatments can be introduced to clinical practice, such as transplanted cell dosage, and administration route.…”