Therapeutic Potential of Medicinal Plants against Dengue Infection: A Mechanistic Viewpoint

Altamish, Mohammad; Khan, Muzayyana; Baig, Mirza Sarwar; Pathak, Bharti; Rani, Veena; Akhtar, Jamal; Khan, AsimAli; Ahmad, Sayeed; Krishnan, Anuja

doi:10.1021/acsomega.2c00625

Cited by 27 publications

(5 citation statements)

References 84 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On this basis, neem plants can be used to find the active ingredient having potential anti-dengue phytochemicals. Its main compounds azadirchtin and salanin, also showed interaction with dengue NS2/NS3 and NS5 gene in a previous study (Altamish et al, 2022;Rao and Yeturu, 2020); (Parida et al, 2002b) GLY, GLU, THR, and LYS. Desacetyl salanin exhibited strong hydrophobic interaction in line with the previous study (Altamish et al, 2022); (Chavda et al, 2022).…”

Section: Molecular Dockingmentioning

confidence: 82%

“…Its main compounds azadirchtin and salanin, also showed interaction with dengue NS2/NS3 and NS5 gene in a previous study (Altamish et al, 2022;Rao and Yeturu, 2020); (Parida et al, 2002b) GLY, GLU, THR, and LYS. Desacetyl salanin exhibited strong hydrophobic interaction in line with the previous study (Altamish et al, 2022); (Chavda et al, 2022). Similarly, Castalagin and Azadirachtin showed good antiviral properties against NS5 and inhibited viral replication in vitro (Qamar et al, 2017).…”

Section: Molecular Dockingmentioning

confidence: 82%

See 1 more Smart Citation

Antiviral Screening of Azadirachta Indica Phytochemicals as Dengue Ns5 Inhibitor: A Molecular Docking Approach

NAWAZ,

IJAZ

2023

Biol Clin Sci Res J

View full text Add to dashboard Cite

Dengue has been an alarming viral infection in tropical and subtropical regions of the world for the past few decades, resulting in millions of deaths. There is no effective drug to treat this arbovirus-based infection. Dengue virus non-structural protein NS5 contains N terminus methyl transferase domain and C terminus RNA-dependent RNA polymerase domain, which is involved in viral RNA replication and serves as a potential target. The current in-silico study aims to find new potential dengue virus NS5 protein inhibitors. The designed library containing eight compounds from Azadirachta Indica was used to perform molecular docking against active residues of dengue virus NS5 protein. Four compounds (Desacetyl Salanin, Azadirchtin-A, Castalagin, Vilasinin) with high negative binding energy values and zero RMSD values were selected, and their drug-likeness and ADMET analysis was performed. Among the best-docked compounds, Vilasinin (-11kcal/mol) exhibited drug-like properties as it has a molecular weight less than 500 D and has zero violation value. Moreover, it has 5 hydrogen bond donors and 10 hydrogen bond acceptors. It is well soluble in water so that it can be used as a potential inhibitor and drug candidate for the treatment of dengue infection.

show abstract

Section: Molecular Dockingmentioning

confidence: 82%

Section: Molecular Dockingmentioning

confidence: 82%

Antiviral Screening of Azadirachta Indica Phytochemicals as Dengue Ns5 Inhibitor: A Molecular Docking Approach

NAWAZ,

IJAZ

2023

Biol Clin Sci Res J

View full text Add to dashboard Cite

show abstract

“…Many herbal extracts derived from plants have been used to isolate individual molecules that exhibit potential as therapeutic candidates. These molecules are now being employed in many biochemical and biomedical fields [34]. The value obtained for the selected compounds was highly favorable and exhibited characteristic features with favorable indications of their potential as drug candidates.…”

Section: Plos Onementioning

confidence: 99%

Identification of natural antiviral drug candidates against Tilapia Lake Virus: Computational drug design approaches

Sumon,

Asseri,

Molla

et al. 2023

PLoS ONE

View full text Add to dashboard Cite

Tilapia Lake Virus (TiLV) is a disease that affects tilapia fish, causing a high rate of sudden death at any stage in their life cycle. Unfortunately, there are currently no effective antiviral drugs or vaccines to prevent or control the progression of this disease. Researchers have discovered that the CRM1 protein plays a critical function in the development and spreading of animal viruses. By inhibiting CRM1, the virus’s spread in commercial fish farms can be suppressed. With this in mind, this study intended to identify potential antiviral drugs from two different tropical mangrove plants from tropical regions: Heritiera fomes and Ceriops candolleana. To identify promising compounds that target the CRM1 protein, a computer-aided drug discovery approach is employed containing molecular docking, ADME (absorption, distribution, metabolism and excretion) analysis, toxicity assessment as well as molecular dynamics (MD) simulation. To estimate binding affinities of all phytochemicals, molecular docking is used and the top three candidate compounds with the highest docking scores were selected, which are CID107876 (-8.3 Kcal/mol), CID12795736 (-8.2 Kcal/mol), and CID12303662 (-7.9 Kcal/mol). We also evaluated the ADME and toxicity properties of these compounds. Finally, MD simulation was conducted to analyze the stability of the protein-ligand complex structures and confirm the suitability of these compounds. The computational study demonstrated that the phytochemicals found in H. fomes and C. candolleana could potentially serve as important inhibitors of TiLV, offering practical utility. However, further in vivo investigations are necessary to investigate and potentially confirm the effectiveness of these compounds as antiviral drugs against the virus TiLV.

show abstract

“…Plant-based medicines contain bioactive compounds that possess antiviral, anti-inflammatory, and immunomodulatory properties, making them an advantageous addition to managing dengue fever. Many plants, including Arrabidaea pulchra, Andrographis paniculata, Mimosa catechu, Carica papaya, Azadirachta indica, Allium sativum, Ficus septica, and Quercus lusitanica, have shown potential activity against dengue fever treatment (Huang et al 2017;Ali-Seyed and Vijayaraghavan 2020;Ester et al 2020;Lim et al 2021;Dwivedi et al 2021;Altamish et al 2022;Babbar et al 2023). These plants contain diverse bioactive compounds, such as alkaloids, Phenolics and flavonoids, contributing to their therapeutic properties.…”

Section: Medicinal Plants Against Dengue Fevermentioning

confidence: 99%

Management and Control of Dengue Fever through One Health Approach

2023

IJAB

View full text Add to dashboard Cite

Dengue fever, a virus transmitted by mosquitoes, continues to pose a significant health challenge on a global scale, especially in tropical areas. The One Health approach, which considers the interconnected areas of human, animal, and environmental health, is becoming a comprehensive strategy for managing and controlling this intricate infectious disease. A key aspect involves improved diagnostic abilities and smooth information exchange between healthcare facilities, which are crucial for surveillance and early detection. Effective dengue management relies on cooperation between public health and environmental agencies to carry out specific interventions such as insecticides, biological controls, and environmental modifications to prevent mosquito breeding. This collaboration is vital for controlling dengue. At the same time, a comprehensive approach to environmental management includes coordinated land use planning and recognizes the influence of climate change on mosquito carriers. Public awareness initiatives are essential in highlighting the importance of community involvement and individual accountability in reducing the breeding grounds for mosquitoes. It is crucial to conduct interdisciplinary research in order to progress our comprehension of dengue patterns and to encourage the development of inventive control methods, such as the genetic alteration of mosquitoes. In terms of policy, it is crucial to encourage collaboration between different agencies and countries, to support the creation and execution of policies that align with a unified One Health approach. By combining forces from various fields such as health, agriculture, environment, and education, the One Health strategy provides an effective way to reduce the spread of dengue fever, recognizing the complex interconnections between humans, animals, and the environment. This comprehensive method not only strengthens our ability to protect against dengue, but also lays a strong groundwork for tackling other new infectious risks that affect multiple areas of health.

show abstract

Therapeutic Potential of Medicinal Plants against Dengue Infection: A Mechanistic Viewpoint

Cited by 27 publications

References 84 publications

Antiviral Screening of Azadirachta Indica Phytochemicals as Dengue Ns5 Inhibitor: A Molecular Docking Approach

Antiviral Screening of Azadirachta Indica Phytochemicals as Dengue Ns5 Inhibitor: A Molecular Docking Approach

Identification of natural antiviral drug candidates against Tilapia Lake Virus: Computational drug design approaches

Management and Control of Dengue Fever through One Health Approach

Contact Info

Product

Resources

About