Therapeutic potential of mangiferin against kidney disorders and its mechanism of action: A review

Lum, Pei Teng; Sekar, Mahendran; Gan, Siew Hua; Jeyabalan, Srikanth; Bonam, Srinivasa Reddy; Rani, Nur Najihah Izzati Mat; Ku-Mahdzir, Ku-Marina; Seow, Lay-Jing; Wu, Yuan Seng; Subramaniyan, Vetriselvan; Fuloria, Neeraj Kumar; Fuloria, Shivkanya

doi:10.1016/j.sjbs.2021.11.016

Cited by 24 publications

(12 citation statements)

References 71 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…LY294002, as an autophagy inhibitor, inhibits the phosphorylation of AKT through broad-spectrum suppression of PI3K, and final achieves autophagy inhibition [ 35 ]. Some literatures have reported that autophagy retardation could aggravate glomerular diseases, suggesting that increased autophagy may attenuate MN [ 37 , 38 ]. Here, we found that LY294002 could reverse the reduction of mesangial cells proliferation and inflammation after SalB intervention.…”

Section: Discussionmentioning

confidence: 99%

Salvianolic acid B attenuates membranous nephropathy by activating renal autophagy via microRNA-145-5p/phosphatidylinositol 3-kinase/AKT pathway

Chen

Luo

et al. 2022

Bioengineered

View full text Add to dashboard Cite

The abnormal proliferation and inflammatory response of the mesangial cells play a crucial role in the progression of membranous nephropathy (MN). Herein, this study aimed to investigate the therapeutic effect of Salvianolic acid B (SalB) on MN-induced mesangial abnormalities and its underlying mechanisms. MN models were established in cationic bovine serum albumin-induced Sprague-Dawley rats and lipopolysaccharide-induced human mesangial cells (HMCs). Following SalB and microRNA-145-5p antagomir treatment, kidney function was investigated by 24-hours urine protein, serum creatinine, and blood urea nitrogen. Pathological changes of kidney were investigated by Periodic acid Schiff staining. CD68 and IgG were detected by immunofluorescence in glomerulus. Mesangial autophagosomes were observed by transmission electron microscope. MicroRNA-145-5p inhibitor, mimic, LY294002, and SalB were used to treat with HMCs. In kidney and HMCs, IL-1 , IL-2, IL-6, TNF- and microRNA-145-5p was detected by quantitative real-time PCR. Phosphatidylinositol 3-kinase (PI3K), phosphorylated AKT, AKT, beclin1, and microtubule-associated protein light chain 3 (LC3) levels were detected by Western blot. HMCs proliferation and cycle were detected by Cell Counting Kit-8 and flow cytometry. LC3 were detected by LC3-dual-fluorescent adenovirus in HMCs. Our results showed that SalB significantly ameliorated kidney function and pathological changes. Furthermore, it significantly alleviated proliferation, inflammation and activated autophagy in mesangial cells. Moreover, microRNA-145-5p antagomir accentuated MN while microRNA-145-5p inhibitor and LY294002 encouraged proliferation and inflammation through PI3K/AKT pathway in HMCs. Collectively, our study demonstrated that SalB activated renal autophagy to reduce cell proliferation and inflammation of MN, which was mediated by microRNA-145-5p to inhibit PI3K/AKT pathway, and ultimately attenuated MN.

show abstract

Section: Discussionmentioning

confidence: 99%

Salvianolic acid B attenuates membranous nephropathy by activating renal autophagy via microRNA-145-5p/phosphatidylinositol 3-kinase/AKT pathway

Chen

Luo

et al. 2022

Bioengineered

View full text Add to dashboard Cite

show abstract

“…Mangiferinis mainly extracted from Mangifera persiciformis, Anemarrhena asphodeloides , and Mangifera indica ( Akter et al, 2022 ; Wang et al, 2022 ). It plays an important role in the progression of kidney disorders ( Lum et al, 2022 ), diabetes ( Aswal et al, 2020 ), cancer ( Morozkina et al, 2021 ), and osteoarthritis ( Qu et al, 2017 ; Li et al, 2019 ). It has crucial anti-inflammatory ( Wang R. et al, 2021 ; Li N. et al, 2021 ) and antioxidant functions ( Huang et al, 2020 ; Samadarsi and Dutta, 2020 ; Ismail et al, 2021 ); its application has also been reported in the treatment of IDD.…”

Section: Phytochemicals For the Treatment Of Idd By Targeting Inflamm...mentioning

confidence: 99%

Targeting Oxidative Stress and Inflammation in Intervertebral Disc Degeneration: Therapeutic Perspectives of Phytochemicals

et al. 2022

View full text Add to dashboard Cite

Low back pain is a major cause of disability worldwide that declines the quality of life; it poses a substantial economic burden for the patient and society. Intervertebral disc (IVD) degeneration (IDD) is the main cause of low back pain, and it is also the pathological basis of several spinal degenerative diseases, such as intervertebral disc herniation and spinal stenosis. The current clinical drug treatment of IDD focuses on the symptoms and not their pathogenesis, which results in frequent recurrence and gradual aggravation. Moreover, the side effects associated with the long-term use of these drugs further limit their use. The pathological mechanism of IDD is complex, and oxidative stress and inflammation play an important role in promoting IDD. They induce the destruction of the extracellular matrix in IVD and reduce the number of living cells and functional cells, thereby destroying the function of IVD and promoting the occurrence and development of IDD. Phytochemicals from fruits, vegetables, grains, and other herbs play a protective role in the treatment of IDD as they have anti-inflammatory and antioxidant properties. This article reviews the protective effects of phytochemicals on IDD and their regulatory effects on different molecular pathways related to the pathogenesis of IDD. Moreover, the therapeutic limitations and future prospects of IDD treatment have also been reviewed. Phytochemicals are promising candidates for further development and research on IDD treatment.

show abstract

“…[53][54][55][56] Naringin enhances bone regeneration 57 and has a theraupeutic effect on osteoporosis. 58 Mangiferin has benefits against kidney, 59 neurodegenerative 60 and allergic asthma 61 disorders. Thus, using the developed approach, it was found that I. sibirica L. extracts have valuable biologically active properties.…”

Section: Procedures For the Optimisation Of Extraction Of Flavonoids ...mentioning

confidence: 99%

Development of approach for flavonoid profiling of biotechnological raw materials Iris sibirica L. by HPLC with high‐resolution tandem mass spectrometry

Karpitskiy

Бессонова

Карцова

et al. 2022

Phytochemical Analysis

View full text Add to dashboard Cite

Introduction Iris L. are promising in medicine due to the biological activity of extracts. Iris sibirica L. is spread in Russia but its phytochemical composition has not been studied in detail though it is included in the Red Book. For this reason, I. sibirica L. biotechnology is in high demand. One of the key points in biotechnology is the regulation of plant metabolism using phytohormones. Obtaining of chromatographic metabolite profiles allows to control this process. Objective The aim of this study was to develop an approach for effective control of biotechnological raw materials of I. sibirica L. by flavonoid profiles using high‐performance liquid chromatography–tandem mass spectrometry (HPLC–MS/MS) and to investigate the influence of phytohormones in nutrient media on content of flavonoids. Methodology Iris sibirica L. regenerated plants were grown on Murashige–Skoog media with 6‐benzylaminopurine (6‐BAP) and α‐naphtylacetic acid (NAA) additives. To optimise extraction conditions, the design of the experiment was used. Profiles of polyphenols were obtained by HPLC–MS/MS in the positive and negative ionisation modes. Results The process for efficient extraction from leaves of I. sibirica L. were developed. The factors influencing the extraction efficiency of flavonoids have been determined. A total of 36 compounds were identified by HPLC–MS/MS. Among them isoflavones and their glycosides are the main classes. Addition of an auxin‐like hormone increased the non‐polar flavonoid levels, but decreased the polar ones. The variation in concentration of cytokinin (6‐BAP) affected almost all of the analytes. Conclusion The methodology for effective control of I. sibirica L. raw plant material biotechnology was developed by analysing obtained chromatographic polyphenol profiles.

show abstract

Therapeutic potential of mangiferin against kidney disorders and its mechanism of action: A review

Cited by 24 publications

References 71 publications

Salvianolic acid B attenuates membranous nephropathy by activating renal autophagy via microRNA-145-5p/phosphatidylinositol 3-kinase/AKT pathway

Salvianolic acid B attenuates membranous nephropathy by activating renal autophagy via microRNA-145-5p/phosphatidylinositol 3-kinase/AKT pathway

Targeting Oxidative Stress and Inflammation in Intervertebral Disc Degeneration: Therapeutic Perspectives of Phytochemicals

Development of approach for flavonoid profiling of biotechnological raw materials Iris sibirica L. by HPLC with high‐resolution tandem mass spectrometry

Contact Info

Product

Resources

About