Therapeutic potential of Lactobacillus plantarum CJLP133 for house-dust mite-induced dermatitis in NC/Nga mice

Won, Tae Joon; Kim, Bongjoon; Lee, Yun‐Jung; Bang, Joon Seok; Oh, Eun Seul; Yoo, Jaeeun; Hyung, Kyeong Eun; Yoon, Joowon; Hwang, Sung Ho; Park, Eon Sub; Park, Soyoung; Hwang, Kwang Woo

doi:10.1016/j.cellimm.2012.05.013

Cited by 20 publications

(10 citation statements)

References 37 publications

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“…In another study, Lctbs plantarum strains from Kimchi were investigated for their capacity to inhibit AD (house dust mite-induced dermatitis) in NC/Nga mouse. The three strains, CJLP55, CJLP133, and CJLP136, suppressed AD-like skin lesions and epidermal thickening [13, 23, 87]. …”

Section: Experimental (Animal Model) and Clinical (Human) Studies mentioning

confidence: 99%

Preventative and Therapeutic Probiotic Use in Allergic Skin Conditions: Experimental and Clinical Findings

Özdemir

Erol

2013

BioMed Research International

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Probiotics are ingested live microbes that can modify intestinal microbial populations in a way that benefits the host. The interest in probiotic preventative/therapeutic potential in allergic diseases stemmed from the fact that probiotics have been shown to improve intestinal dysbiosis and permeability and to reduce inflammatory cytokines in human and murine experimental models. Enhanced presence of probiotic bacteria in the intestinal microbiota is found to correlate with protection against allergy. Therefore, many studies have been recently designed to examine the efficacy of probiotics, but the literature on the allergic skin disorders is still very scarce. Here, our objective is to summarize and evaluate the available knowledge from randomized or nonrandomized controlled trials of probiotic use in allergic skin conditions. Clinical improvement especially in IgE-sensitized eczema and experimental models such as atopic dermatitis-like lesions (trinitrochlorobenzene and picryl chloride sensitizations) and allergic contact dermatitis (dinitrofluorobenzene sensitization) has been reported. Although there is a very promising evidence to recommend the addition of probiotics into foods, probiotics do not have a proven role in the prevention or the therapy of allergic skin disorders. Thus, being aware of possible measures, such as probiotics use, to prevent/heal atopic diseases is essential for the practicing allergy specialist.

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Section: Experimental (Animal Model) and Clinical (Human) Studies mentioning

confidence: 99%

Preventative and Therapeutic Probiotic Use in Allergic Skin Conditions: Experimental and Clinical Findings

Özdemir

Erol

2013

BioMed Research International

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“…Won et al . have shown that serum IFN‐γ and IL‐10 concentrations are increased during probiotic treatment, whereas these cytokines are repressed in lymph node cells by the end of the treatment . By the end of our study, on Day 56, the RHT3201‐fed groups were moving towards having similar histopathological and immunological characteristics as the normal control group.…”

Section: Discussionmentioning

confidence: 52%

Therapeutic effect of tyndallized Lactobacillus rhamnosus IDCC 3201 on atopic dermatitis mediated by down‐regulation of immunoglobulin E in NC/Nga mice

Lee

Yoon

Kim

et al. 2016

Microbiology and Immunology

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The therapeutic effect of oral administration of Lactobacillus rhamnosus IDCC 3201 tyndallizate (RHT3201) on atopic dermatitis (AD)-like skin lesions in NC/Nga mice were investigated. After induction of dermatitis in NC/Nga mice with house-dust mite extract, each group was fed RHT3201 with 1 × 10(8) , 1 × 10(9) , or 1 × 10(10) cells orally once a day for 8 weeks. Dermatitis scores and frequency of scratching were improved by oral feeding with RHT3201. In contrast to the control group, RHT3201-fed mice showed significantly down-regulated mast cell numbers and serum immunoglobulin E (IgE) concentrations had significantly less IL4 in their axillary lymph node cells. The therapeutic effect of RHT3201 was found to be dose-dependent. These findings indicate that RHT3201 has potential for treating AD.

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“…GQ336971) strain was isolated from kimchi, which is the most popular fermented food in Korea and is easily obtained. 27 This strain also has the potential to improve mouse and human AD. 28 29 Finally, we decided to use L. plantarum for the experiment, and L. plantarum culture medium was donated by Probiotics Research Center, CJ CheilJedang Corporation, Korea.…”

Section: Methodsmentioning

confidence: 99%

Lactobacillus plantarum-derived Extracellular Vesicles Protect Atopic Dermatitis Induced byStaphylococcus aureus-derived Extracellular Vesicles

Kim

Choi²,

Choi

et al. 2018

Allergy Asthma Immunol Res

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PurposeThe microbial environment is an important factor that contributes to the pathogenesis of atopic dermatitis (AD). Recently, it was revealed that not only bacteria itself but also extracellular vesicles (EVs) secreted from bacteria affect the allergic inflammation process. However, almost all research carried out so far was related to local microorganisms, not the systemic microbial distribution. We aimed to compare the bacterial EV composition between AD patients and healthy subjects and to experimentally find out the beneficial effect of some bacterial EV compositionMethodsTwenty-seven AD patients and 6 healthy control subjects were enrolled. After urine and serum were obtained, EVs were prepared from samples. Metagenomic analysis of 16s ribosomal DNA extracted from the EVs was performed, and bacteria showing the greatest difference between controls and patients were identified. In vitro and in vivo therapeutic effects of significant bacterial EV were evaluated with keratinocytes and with Staphylococcus aureus-induced mouse AD models, respectively.ResultsThe proportions of Lactococcus, Leuconostoc and Lactobacillus EVs were significantly higher and those of Alicyclobacillus and Propionibacterium were lower in the control group than in the AD patient group. Therefore, lactic acid bacteria were considered to be important ones that contribute to the difference between the patient and control groups. In vitro, interleukin (IL)-6 from keratinocytes and macrophages decreased and cell viability was restored with Lactobacillus plantarum-derived EV treatment prior to S. aureus EV treatment. In S. aureus-induced mouse AD models, L. plantarum-derived EV administration reduced epidermal thickening and the IL-4 level.ConclusionsWe suggested the protective role of lactic acid bacteria in AD based on metagenomic analysis. Experimental findings further suggest that L. plantarum-derived EV could help prevent skin inflammation.

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Therapeutic potential of Lactobacillus plantarum CJLP133 for house-dust mite-induced dermatitis in NC/Nga mice

Cited by 20 publications

References 37 publications

Preventative and Therapeutic Probiotic Use in Allergic Skin Conditions: Experimental and Clinical Findings

Preventative and Therapeutic Probiotic Use in Allergic Skin Conditions: Experimental and Clinical Findings

Therapeutic effect of tyndallized Lactobacillus rhamnosus IDCC 3201 on atopic dermatitis mediated by down‐regulation of immunoglobulin E in NC/Nga mice

Lactobacillus plantarum-derived Extracellular Vesicles Protect Atopic Dermatitis Induced byStaphylococcus aureus-derived Extracellular Vesicles

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