Therapeutic Potential of Kaempferol against Sleep Deprivation-Induced Cognitive Impairment: Modulation of Neuroinflammation and Synaptic Plasticity Disruption in Mice

Du, Ya-Ya; Sun, Ting; Yang, Qi; Liu, Qing-Qing; Li, Jia-Min; Yang, Le; Luo, Lan-Xin

doi:10.1021/acsptsci.3c00226

Cited by 4 publications

(1 citation statement)

References 36 publications

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“…MLR refers to the oral supplementation with natural cell membrane glycerophospholipids and kaempferol (3,4′,5,7-tetrahydroxyflavone), a natural flavonoid found in tea, broccoli, cabbage, kale, beans, endive, leek, tomato, strawberries, and grapes [ 161 ]. Kaempferol is a glycogen synthase kinase-3β (GSK-3β) inhibitor which prevents sleep deprivation-induced cognitive decline [ 162 , 163 ]. Like lithium and several antipsychotic drugs, kaempferol blocks GSK-3β, an enzyme previously implicated in SCZ and circadian rhythm disorders, suggesting that this natural compound may exert antipsychotic properties without the adverse effects of conventional therapeutics [ 164 , 165 , 166 , 167 ].…”

Section: Mitochondria and Aryl Hydrocarbon Receptormentioning

confidence: 99%

Insomnia in Forensic Detainees: Is Salience Network the Common Pathway for Sleep, Neuropsychiatric, and Neurodegenerative Disorders?

Sfera,

Thomas,

Ogunjale

et al. 2024

JCM

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Forensic hospitals throughout the country house individuals with severe mental illness and history of criminal violations. Insomnia affects 67.4% of hospitalized patients with chronic neuropsychiatric disorders, indicating that these conditions may hijack human somnogenic pathways. Conversely, somnolence is a common adverse effect of many antipsychotic drugs, further highlighting a common etiopathogenesis. Since the brain salience network is likely the common denominator for insomnia, neuropsychiatric and neurodegenerative disorders, here, we focus on the pathology of this neuronal assembly and its likely driver, the dysfunctional neuronal and mitochondrial membrane. We also discuss potential treatment strategies ranging from membrane lipid replacement to mitochondrial transplantation. The aims of this review are threefold: 1. Examining the causes of insomnia in forensic detainees with severe mental illness, as well as its role in predisposing them to neurodegenerative disorders. 2. Educating State hospital and prison clinicians on frontotemporal dementia behavioral variant, a condition increasingly diagnosed in older first offenders which is often missed due to the absence of memory impairment. 3. Introducing clinicians to natural compounds that are potentially beneficial for insomnia and severe mental illness.

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