Therapeutic Potential of Hydrogel Based Sodium Alginate and Chitosan as A Multifunctional Drug Delivery System for Atopic Dermatitis
Kiran Singh,
Mahendra Kumar Sahu,
Deepa Thakur
et al.
Abstract:Tetramethylpyrazine (TMP) has low bioavailability due to its fast metabolism and short half-life, which is not conducive to transdermal treatment of atopic dermatitis (AD). Therefore, in this study, TMP was encapsulated into liposomes (Lip) by film dispersion method, and then the surface of Lip was modified by sodium alginate (ALG) and chitosan (CS). The tetramethylpyrazine-loaded liposomes in sodium alginate chitosan hydrogel called T-Lip-AC hydrogel. In vitro experiments, we found that T-Lip-AC hydrogel not … Show more
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