Therapeutic potential of dental stem cells

Chalisserry, Elna Paul; Nam, Seung Yun; Park, Sang Hyug; Anil, Sukumaran

doi:10.1177/2041731417702531

Cited by 158 publications

(163 citation statements)

References 161 publications

(223 reference statements)

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“…In corneal production A study put forward its findings that a tissue engineered DPSC sheet when transplanted on the corneal bed and further on it was converted with the help of de-epithelialized human amniotic membrane, the histological analysis at three months postoperative phase confirmed that a healthy uniform corneal epithelium was formed. Thus, it was concluded that tissue engineered DPSC sheet was successful for the reconstruction of corneal epithelium (18,45).…”

Section: Differentiation To Hepatocytementioning

confidence: 99%

Human Dental Pulp Stem Cells – A Prospective Regenerative Therapy

Tiwari¹

2018

IJTSRD

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Stem cells are the pluripotent cells that possess the potential to differentiate into a variety of cells of the human body. The knowledge of stem cell is enhancing not only in the medical field but equally in the dental field too. The stem cells of the dental origin provide remedies to many cell-based therapies in the regenerative medicine. Dental pulp stem cells (DPSCs) possess the mesenchymal stem cells phenotype and therefore get differentiated into neuron, chondrocytes, cardiomyocytes. The demand of cry preserving human exfoliated deciduous teeth (SHED) cells or the DPSCs are gaining popularity, in a similar fashion of the umbilical cord blood storage. The dental pulp stem cells are the adult multipotent cells that thrive in the cell abundant zone of the dental pulp. Accordingly, this multipotent characteristic makes the DPSCs an apt model to be incorporated in both dental and medical applications respectively. Therefore, this review which has been executed by both the electronic and hand-searching tools provides an outline of the applications of the dental pulp stem cells in the treatment of various medical disorders, nevertheless other aspects like the long-term clinical trials and studies needs more investigation to ascertain their efficacy.

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Section: Differentiation To Hepatocytementioning

confidence: 99%

Human Dental Pulp Stem Cells – A Prospective Regenerative Therapy

Tiwari¹

2018

IJTSRD

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“…Dental stem cells (DSCs) are self-renewable teeth cells, which help maintain or develop oral tissues 6 . In the literature, there are various types of dental adult stem cells, such as dental pulp stem cells (DPSCs), stem cells from human exfoliated deciduous teeth (SHEDs), periodontal ligament stem cells or stem cells of the developing root apical papilla (SCAPs), dental follicle stem cells (DFSCs), and dental MSCs (DMSCs) 7,8 .…”

Section: Introductionmentioning

confidence: 99%

Dental stem cells in tooth repair: A systematic review

2019

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Background: Dental stem cells (DSCs) are self-renewable teeth cells, which help maintain or develop oral tissues. These cells can differentiate into odontoblasts, adipocytes, cementoblast-like cells, osteoblasts, or chondroblasts and form dentin/pulp. This systematic review aimed to summarize the current evidence regarding the role of these cells in dental pulp regeneration. Methods: We searched the following databases: PubMed, Cochrane Library, MEDLINE, SCOPUS, ScienceDirect, and Web of Science using relevant keywords. Case reports and non-English studies were excluded. We included all studies using dental stem cells in tooth repair whether in vivo or in vitro studies. Results: Dental pulp stem cell (DPSCs) is the most common type of cell. Most stem cells are incorporated and implanted into the root canals in different scaffold forms. Some experiments combine growth factors such as TDM, BMP, and G-CSF with stem cells to improve the results. The transplant of DPSCs and stem cells from apical papilla (SCAPs) was found to be associated with pulp-like recovery, efficient revascularization, enhanced chondrogenesis, and direct vascular supply of regenerated tissue. Conclusion: The current evidence suggests that DPSCs, stem cells from human exfoliated deciduous teeth, and SCAPs are capable of providing sufficient pulp regeneration and vascularization. For the development of the dental repair field, it is important to screen for more effective stem cells, dentine releasing therapies, good biomimicry scaffolds, and good histological markers.

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“…24,26 Dental/oral stem cells Mesenchymal stem cells can be isolated from several dental locations (pulp, exfoliated primary deciduous teeth, apical papilla, dental follicule, periodontal ligament) as well as from some other oral tissues (gingiva, oral mucosa, craniofacial bone). 27 Dental stem cells (DSCs) are derived from neural crest post natal stem cell populations with MSC-like characteristics. Compared to BM-MSCs, the DMSCs appear to be more related to odontogenic than osteogenic development.…”

Section: 25mentioning

confidence: 99%

Briefly about Mesenchymal Stem Cells - One of the Main Players in Bone Tissue Engineering

Alexandrova

Zhivkova

Dyakova

et al. 2018

ACP

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Bone joint pathologies caused by several diseases, congenital defects, infections and trauma significantly decrease the quality of human's life, may be life-limiting and are recognized to be among the major health and social challenges of our time.1,2 Bone has a remarkable regenerative potential -fracture healing is a complex process that follows specific regenerative patterns involving several molecular, genetic, biochemical and cellular mechanisms. When the size of the lost bone is greater than the healing capacity of osteogenic tissues there is a need of bone implants. Nowadays, autologous (the gold standard for repairing bone defects) and allogeneic bone grafts are still widely used in clinical practice for repairing bone defects but their application has been connected with various challenges including limited availability, additional surgical trauma and postoperative complications (in the case of autografts), foreign body immune reactions, risk of infections (for example transmission of Hepatitis C virus, Human immunodeficiency virus), poor degree of cellularity, less revascularization and a higher resorption rate (in the case of allografts). 3,4 That is why there is an urgent need for design of suitable substitute with improved incorporation, osteogenicity, osteoconductivity, and osteoinductivity that can mimic to the highest degree the biological, physical and mechanical characteristics of the normal autogenous bone. Bone tissue engineeringBone tissue engineering (BTE) is a strategy combining the knowledge and principles of orthopedics, bioengineering, molecular/ cellular biology, cell transplantation, and materials' science to construct substitutes that can restore and maintain normal functions of injured and diseased bone. This innovative approach involves the use of stem cells that are seeded into 3D biocompatible scaffolds and induced by appropriate stimulation (growth factors, cytokines, etc) to generate genuine new bone. 2,4,5 Stem cellsStem cells (SCs) are unspecialized types of cells with the ability to proliferate, self-renew and differentiate under certain physiologic conditions and signaling. The initial concept of stem cells appeared more than one century ago. Although the major advances in clarifying the biology / behavior of SCs that occurred over the last three decades, our knowledge about their nature and ability to explore therapeutic potential are still insufficient.6,7 As compared to embryonic stem cells (ESCs) the adult (or somatic) stem cells are rare, quiescent cells with a more limited self-renewal and differentiation. At the same time, adult stem cells have two very important advantages: they circumvent ethical issues and show less tumorigenicity. Thousands of clinical trials using stem cells are currently in progress. Mesenchymal stem cellsMesenchymal stem cells (MSCs -multipotent stem cells with fibroblast-like morphology) are of mesodermal origin, except for the facial bones, which arise from neural crest.9 MSCs can be isolated from several adult tissues (bone marrow, adipose ...

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Therapeutic potential of dental stem cells

Cited by 158 publications

References 161 publications

Human Dental Pulp Stem Cells – A Prospective Regenerative Therapy

Human Dental Pulp Stem Cells – A Prospective Regenerative Therapy

Dental stem cells in tooth repair: A systematic review

Briefly about Mesenchymal Stem Cells - One of the Main Players in Bone Tissue Engineering

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