Therapeutic Potential of Combined Therapy of Vitamin A and Vitamin C in the Experimental Autoimmune Encephalomyelitis (EAE) in Lewis Rats

Navidhamidi, Mojdeh; Nazari, Atena; Dehghan, Samaneh; Ebrahimpour, Anahita; Nasrnezhad, Reza; Pourabdolhossein, Fereshteh

doi:10.1007/s12035-022-02755-0

Cited by 5 publications

(4 citation statements)

References 69 publications

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“…70 And it was interesting to find that the high level of β-retinol could improve oxidative stress by upregulating the expressions of Nrf2, HMOX1 and glutathione and downregulate the expression of MDA. 71,72 The higher level of β-retinol in the Rg3-H group than in the OVA group was also found in our study. (iii) α-Linolenic acid had a positive effect on diminishing airway inflammation by reversing low levels of glutathione and SOD and high level of MDA.…”

Section: Papersupporting

confidence: 85%

Integration of transcriptomics and metabolomics to reveal the effect of ginsenoside Rg3 on allergic rhinitis in mice

Liu

Yang

et al. 2023

Food Funct.

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Section: Papersupporting

confidence: 85%

Integration of transcriptomics and metabolomics to reveal the effect of ginsenoside Rg3 on allergic rhinitis in mice

Liu

Yang

et al. 2023

Food Funct.

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“…VC plays an essential role in the myelination of peripheral nerves and can regulate Schwann cell myelination by promoting DNA demethylation of pro‐myelinating genes (Huff et al., 2021) as well as benefit Lewis Rats with experimental autoimmune encephalomyelitis (Navidhamidi et al., 2022). However, little attention has been paid to the effects of VC on the myelin sheath in the CNS.…”

Section: Discussionmentioning

confidence: 99%

L‐ascorbyl‐2‐phosphate alleviates white matter injury caused by chronic hypoxia through the PRMT5/P53/NF‐κB pathway

Ding,

Lou,

Qin

et al. 2024

Journal of Neurochemistry

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White matter injury (WMI) is one of the most serious complications associated with preterm births. Damage to oligodendrocytes, which are the key cells involved in WMI pathogenesis, can directly lead to myelin abnormalities. L‐ascorbyl‐2‐phosphate (AS‐2P) is a stable form of vitamin C. This study aimed to explore the protective effects of AS‐2P against chronic hypoxia‐induced WMI, and elucidate the underlying mechanisms. An in vivo chronic hypoxia model and in vitro oxygen–glucose deprivation (OGD) model were established to explore the effects of AS‐2P on WMI using immunofluorescence, immunohistochemistry, western blotting, real‐time quantitative polymerase chain reaction, Morris water maze test, novel object recognition test, beaming‐walking test, electron microscopy, and flow cytometry. The results showed that AS‐2P resulted in the increased expression of MBP, Olig2, PDGFRα and CC1, improved thickness and density of the myelin sheath, and reduced TNF‐α expression and microglial cell infiltration to alleviate inflammation in the brain after chronic hypoxia. Moreover, AS‐2P improved the memory, learning and motor abilities of the mice with WMI. These protective effects of AS‐2P may involve the upregulation of protein arginine methyltransferase 5 (PRMT5) and downregulation of P53 and NF‐κB. In conclusion, our study demonstrated that AS‐2P attenuated chronic hypoxia‐induced WMI in vivo and OGD‐induced oligodendrocyte injury in vitro possibly by regulating the PRMT5/P53/NF‐κB pathway, suggesting that AS‐2P may be a potential therapeutic option for WMI.

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“…Research on other autoimmune diseases indicates the better success of combined application of different antioxidants. 38 39 It was shown that resveratrol, molecule with strong antioxidative potential, restores Th17/T reg imbalance in ITP patients. 9 Therefore, to achieve a satisfactory therapeutic effect, it is not enough to apply antioxidant therapy at the appropriate time, but it is necessary to apply antioxidant therapy with the appropriate mechanism of action, and in order to achieve this, it is most expedient to apply combination of several antioxidants.…”

Section: Discussionmentioning

confidence: 99%

Variations of Redox Balance in Different Stages of Childhood Immune Thrombocytopenic Purpura

Medovic,

Srejovic,

Medovic

et al. 2023

Thromb Haemost

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Background Few previous studies indicated the role of oxidative stress in the pathogenesis of childhood idiopathic thrombocytopenic purpura (ITP), but there are little data regarding changes in redox balance in different forms of the disease, and changes after therapeutic procedures. We aimed to investigate the values of pro-oxidants and antioxidative capacity in various forms of ITP before and after the applying therapy. Materials and Methods The research included 102 children, classified into the following groups: (1) newly diagnosed ITP (ndITP), (2) persistent ITP, (3) chronic ITP (chITP), and (4) control groups: (A) healthy control and (B) previously experienced ITP—healthy children who had been suffering from ITP earlier. During the clinical assessment, a blood sample was taken from the patients, from which the value of pro-oxidants (index of lipid peroxidation measured as TBARS, nitrites [NO2 −], as measurement of nitric oxide [NO] production, superoxide anion radical [O2 −], and hydrogen peroxide [H2O2]) and the capacity of antioxidant protection (activity of superoxide dismutase and catalase, and quantity of reduced glutathione) were determined spectrophotometrically. Results Our results demonstrated that values of pro-oxidants, especially reflected through the TBARS and O2 −, were the highest in the ndITP and exacerbated chITP groups. Also, the activity of the endogenous antioxidative defense system was the lowest in these groups. Intravenous immunoglobulin therapy in the ndITP group exerted the most prominent effect on the redox balance. Conclusion It can be concluded that severity and exacerbation of the ITP are closely related to the redox status.

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Therapeutic Potential of Combined Therapy of Vitamin A and Vitamin C in the Experimental Autoimmune Encephalomyelitis (EAE) in Lewis Rats

Cited by 5 publications

References 69 publications

Integration of transcriptomics and metabolomics to reveal the effect of ginsenoside Rg3 on allergic rhinitis in mice

Integration of transcriptomics and metabolomics to reveal the effect of ginsenoside Rg3 on allergic rhinitis in mice

L‐ascorbyl‐2‐phosphate alleviates white matter injury caused by chronic hypoxia through the PRMT5/P53/NF‐κB pathway

Variations of Redox Balance in Different Stages of Childhood Immune Thrombocytopenic Purpura

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