Therapeutic potential of bixin on inflammation: a mini review

Abstract

Chronic inflammation is the underlying mechanism for many diseases. Thus, inflammatory signaling pathways are valuable targets for new treatment modalities. Natural products have gained interest as a potential source of bioactive compounds which provide health benefits in combating inflammatory-related diseases. Recent reports have linked the medicinal values of Bixa orellana L. with its anti-inflammatory activities. Therefore, this review aims to examine the therapeutic potential of bixin, a major bioactive constituent found in the seeds of B. orellana, on inflammatory-related diseases based on existing in vitro and in vivo evidence. Additionally, the anti-inflammatory mechanism of bixin via signaling pathways is explored and possible toxic effects are addressed. The findings suggest that bixin may ameliorate inflammation via inhibition of toll-like receptor 4/nuclear factor-kappa B (TLR4/NF-κB), phosphoinositide 3-kinase/protein kinase B (PI3K/Akt) and thioredoxin-interacting protein/NOD-like receptor protein 3 (TXNIP/NLRP3) inflammasome mechanisms. More well-planned clinical studies should be performed to verify its effectiveness and safety profile.

From Extraction to Stabilization: Employing a 22 Experimental Design in Developing Nutraceutical-Grade Bixin from Bixa orellana L.

“…Oil-based food applications, such as dairy spreads, cheese sauces, and processed cheese, are the main uses for bixin due to its oil solubility. To improve its processing in foods and enhance its anti-inflammatory and antioxidant properties [ 52 ], encapsulation techniques are found useful for the development of functional foods. Superoxide, hydroxyl, and peroxyl radicals are examples of reactive oxygen and nitrogen species that they can scavenge.…”

Characterization of Bixin by UV-Visible Spectroscopy and HPLC, and Its Application as Latent Fingermark Developer

“…However, its cultivation has now expanded to the Caribbean, Africa, and Asia. The pigment extracted from its seeds is commercially referred to as annatto, typically used as a spice and dye, providing a yellow-orange hue to various food products [14,15]. Besides that, it is approved as a colorant and additive by the Food and Drug Administration (FDA) and can be extracted using one or a suitable combination of food-grade solvents, such as acetone, ethylene dichloride, hexane, isopropyl alcohol, methyl alcohol, methylene chloride, and trichloroethylene [16,17].…”

Development of topical silver nano gel formulation of Bixin: Characterization, and evaluation of anticancer activity

“…The seeds have commercial value since they contain a pigment called bixin that is extensively employed as a natural tinting agent in the paint and food industry. Bixin (C 25 H 30 O 4 ) is an orange-red colored component containing mostly the carotenoids (80 %) ( Shadisvaaran et al, 2023 ). Owing to the presence of carotenoids, this pigment has been shown to have a number of pharmacological properties, including the ability to reduce fibrosis, function as an antioxidant, reduce inflammation, lower blood cholesterol, treat diabetes, and reduce allergies ( Tao et al, 2021 ).…”