Therapeutic potential of Artemisia vulgaris: An insight into underlying immunological mechanisms

Soon, Laura; Ng, Phui Qi; Chellian, Jestin; Madheswaran, Thiagarajan; Panneerselvam, Jithendra; Gupta, Gaurav; Nammi, Srinivas; Hansbro, Philip M.; Hsu, Alan; Dureja, Harish; Mehta, Meenu; Satija, Saurabh; Dua, Kamal; Collet, Trudi; Chellappan, Dinesh Kumar

doi:10.1615/jenvironpatholtoxicoloncol.2019029397

Cited by 17 publications

(13 citation statements)

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“…The plant possesses antileishmanial, antimalarial, antibacterial, antifungal, anthelmintic, and anti-inflammatory properties [ 102 - 104 ]. Mugwort comprises compounds with significant chemical polymorphisms and contains terpenes, a monoterpenoid, which contributes to the plant’s odor, which is the basis of its insecticidal activity, therefore, employed as an insecticide [ 105 , 106 ].…”

Section: Plants Used In Traditional (Folk) Medicine In Latviamentioning

confidence: 99%

“…A. absinthium serves as a source of numerous conventional and traditional medicines [ 113 ]. The most important chemical constituents in wormwood include flavonoids (santonin) and sesquiterpenes (artemisinin), which exert antiparasitic activities [ 105 , 114 ]. Artemisinin is a “parent drug” of antimalarial agents, and its derivatives have been used since 1980 [ 104 ].…”

Section: Plants Used In Traditional (Folk) Medicine In Latviamentioning

confidence: 99%

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Traditional Latvian herbal medicinal plants used to treat parasite infections of small ruminants: A review

et al. 2021

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Numerous treatment agents offering prophylaxis against livestock parasites are commercially available. However, because of increasing antiparasitic drug resistance, the increased popularity of environmentally friendly lifestyle choices, and organic farming, there is more demand for new alternatives to livestock anthelmintic control strategies and medications. It is important to develop antiparasitics that are safe, effective, inexpensive, and environmentally safe. Local, traditional herbal plants such as tansy, mugwort, wormwood, and heather may serve as treatments for intestinal parasites of sheep. This overview provides knowledge of traditional Latvian plants with antiparasitic activities to establish a database for further research to develop new herbal antiparasitic drugs.

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Section: Plants Used In Traditional (Folk) Medicine In Latviamentioning

confidence: 99%

Section: Plants Used In Traditional (Folk) Medicine In Latviamentioning

confidence: 99%

Traditional Latvian herbal medicinal plants used to treat parasite infections of small ruminants: A review

et al. 2021

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“…The plant possess a broad spectrum of therapeutic properties like antitumor antispasmodic, antisteroidogenic, anti-fertility, antihypertensive, muscle relaxant, antiviral, antibacterial, antioxidant, cholinergic, diuretic etc. [6,7]. It is an important medicinal plant due to the presence of anti-malarial drug artemisinin [8], sesquiterpenes (derivative of artemisinin) and several essential oils [9].…”

Section: A C C E T E Dmentioning

confidence: 99%

Artemisia vulgaris extract causes precocious acrosome reaction and viability loss but low rate of membrane damage in mouse spermatozoa

Bhandari¹,

Sharma²,

Rizal³

et al. 2021

J Anim Sci Technol

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Several herbs including Artemisia are known to possess conceptive property. In the present study, mouse spermatozoa were incubated with ethanol extract of Artemisia vulgaris leaves. The effect of extract on acrosome exocytosis was studied by labeling spermatozoa with fluorescein isothiocyanate (FITC) peanut agglutinin and by staining with Coomassie blue. Viability and membrane integrity were studied by Trypan-blue staining and hypo-osmotic swelling test. Artemisia extract at very low concentration caused precocious acrosome reaction and loss of sperm viability. Acrosome reaction increased remarkably from 22.63% to 88.42% with increasing extract concentration from 0 to 2,000 µg/mL. However, the viability loss of spermatozoa was increased from 11.71% in control to 63.73% in samples treated, evaluated by Trypan-blue staining method. Membrane damage caused by the extract, evaluated by hypo-osmotic swelling test was even low, ranging from 2.27% to only 24.23%. These results indicate that Artemisia extract might block fertilization by causing precocious acrosome exocytosis in spermatozoa. A direct contraceptive effect was tested by injecting the plant extract into the vagina of female mice and then allowing them to mate with normal males. The treated female mice delivered significantly fewer litters in comparison to the control.

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“…The reaction cascade is triggered by external stimuli on the interaction with any of the receptors, namely, B and T cell receptors, cytokine receptors, G-protein-coupled receptors (GPCR), integrins and tyrosine kinase [71]. This interaction activates PI3K and triggers the generation of phosphatidylinositol- (3,4,5)-trisphosphates (also known as PIP3) via phosphorylation. After that, the synthesized PIP3 binds with the pleckstrin homology (PH) domain of Akt for facilitating its transfer to the plasma membrane [72,73].…”

Section: Akt/pkb/pi3k Signaling Pathwaymentioning

confidence: 99%

“…Cell signaling or communication among the cells is one of the key factors in understanding both cellular mechanisms and system functioning [1][2][3][4][5][6]. There are various cell signaling pathways that are involved in a myriad of specific mechanisms in the body, ranging from an antigen triggered antibody response to targeted cells responding to particular hormones.…”

Section: Introductionmentioning

confidence: 99%

Advancing of Cellular Signaling Pathways in Respiratory Diseases Using Nanocarrier Based Drug Delivery Systems

Mehta

Dhanjal

Satija

et al. 2020

CPD

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: Cell Signaling pathways form an integral part of our existence, that allows the cells to comprehend a stimulus and respond back. Such reactions, to external cues from the environment, are required and are essential to regulate the normal functioning of our body. Abnormalities in the system arise when there are errors developed in these signals, resulting in a complication or a disease. Presently, respiratory diseases contribute to being the third leading cause of morbidity worldwide. According to the current statistics, over 339 million people who are asthmatic, 65 million who are suffering from COPD, 2.3 million who are lung cancer patients and 10 million are tuberculosis patients. This toll of statistics with chronic respiratory diseases leaves a heavy burden on society and nation annual health expenditure. Hence, a better understanding of the processes governing these cellular pathways will enable us to treat and manage these deadly respiratory diseases effectively. Moreover, it is important to comprehend the synergy and interplay of the cellular signaling pathways in respiratory diseases, which will enable us to explore and develop suitable strategies for targeted drug delivery. This review, in particular, focuses on the major respiratory diseases and further provides an in-depth discussion on the various cell signaling pathways that are involved in the pathophysiology of respiratory diseases. Moreover, the review also analyses the defining concepts about advanced nano-drug delivery systems involving various nanocarriers and propose newer prospects to minimize the current challenges faced by researchers and formulation scientists.

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Therapeutic potential of Artemisia vulgaris: An insight into underlying immunological mechanisms

Cited by 17 publications

References 0 publications

Traditional Latvian herbal medicinal plants used to treat parasite infections of small ruminants: A review

Traditional Latvian herbal medicinal plants used to treat parasite infections of small ruminants: A review

Artemisia vulgaris extract causes precocious acrosome reaction and viability loss but low rate of membrane damage in mouse spermatozoa

Advancing of Cellular Signaling Pathways in Respiratory Diseases Using Nanocarrier Based Drug Delivery Systems

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