Therapeutic potential of apelin and Elabela in cardiovascular disease

Apelin ameliorates sepsis-induced myocardial dysfunction via inhibition of NLRP3-mediated pyroptosis of cardiomyocytes

“…Apelin, an endogenous ligand for the APJ receptor, exerts essential roles in regulating cardiovascular physiology and pathophysiology [ 17 , 18 ]. Several isotypes of Apelin have been identified with differing number of amino acids, namely Apelin-13, -16, −17, −19, and −36 [ 19 ].…”