Therapeutic Potential of a Candidate relA Deletion Mutant Vaccine of Mycobacterium Avium Subsp. Paratuberculosis

Park, Kun Taek

doi:10.14737/journal.aavs/2014/2.1s.26.31

Cited by 1 publication

(2 citation statements)

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“…Mounting evidence shows it is also the causative agent of Crohn’s disease in humans [ 16 , 17 ]. The Map/relA mutant is one of three deletion mutants developed to test as a candidate vaccine for bovine paratuberculosis [ 11 , 13 , 18 , 19 ]. Ongoing studies have shown deletion of relA abrogates the capacity of Map to establish a persistent infection [ 11 ].…”

Section: Methodsmentioning

confidence: 99%

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Phenotype and Function of CD209+ Bovine Blood Dendritic Cells, Monocyte-Derived-Dendritic Cells and Monocyte-Derived Macrophages

et al. 2016

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Phylogenic comparisons of the mononuclear phagocyte system (MPS) of humans and mice demonstrate phenotypic divergence of dendritic cell (DC) subsets that play similar roles in innate and adaptive immunity. Although differing in phenotype, DC can be classified into four groups according to ontogeny and function: conventional DC (cDC1 and cDC2), plasmacytoid DC (pDC), and monocyte derived DC (MoDC). DC of Artiodactyla (pigs and ruminants) can also be sub-classified using this system, allowing direct functional and phenotypic comparison of MoDC and other DC subsets trafficking in blood (bDC). Because of the high volume of blood collections required to study DC, cattle offer the best opportunity to further our understanding of bDC and MoDC function in an outbred large animal species. As reported here, phenotyping DC using a monoclonal antibody (mAb) to CD209 revealed CD209 is expressed on the major myeloid population of DC present in blood and MoDC, providing a phenotypic link between these two subsets. Additionally, the present study demonstrates that CD209 is also expressed on monocyte derived macrophages (MoΦ). Functional analysis revealed each of these populations can take up and process antigens (Ags), present them to CD4 and CD8 T cells, and elicit a T-cell recall response. Thus, bDC, MoDC, and MoΦ pulsed with pathogens or candidate vaccine antigens can be used to study factors that modulate DC-driven T-cell priming and differentiation ex vivo.

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Section: Methodsmentioning

confidence: 99%

“…It is immune eliminated. A preliminary study has shown it has potential for use in immunotherapy and as a vaccine [ 19 ]. MMP is a 35 kD outer membrane protein with a potential for developing a subunit vaccine [ 9 ].…”

Section: Methodsmentioning

confidence: 99%