Therapeutic potential of a biomedical cellular product in rats with lower limb ischaemia

Лыков, А. П.; Бондаренко, Н. А.; Повещенко, О. В.; Kabakov, Alexander E.; Суровцева, М. А.; Kim, I. I.; Kazakov, O. V.; Повещенко, А. Ф.; Iankaĭte, E V

doi:10.33529/angio2020315

Cited by 3 publications

(1 citation statement)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, radiation therapeutics aim to promote the recovery of hematopoietic function. At present, acute radiation sickness is treated clinically using biological agents, such as cytokines and mesenchymal stem cells (MSCs), modulate normal immune system function ( 127 ) and the secretion of hematopoietic growth factors, and promote reconstruction of the hematopoietic microenvironment ( 128 ). Biological agents have advantages such as low immunogenicity, and ease of transfection and expression of exogenous genes.…”

Section: Strategies To Reduce Radiation Injurymentioning

confidence: 99%

Radioprotective countermeasures for radiation injury (Review)

Liu

Liang

et al. 2023

Mol Med Rep

View full text Add to dashboard Cite

A series of physiological and pathological changes occur after radiotherapy and accidental exposure to ionizing radiation (IR). These changes cause serious damage to human tissues and can lead to death. Radioprotective countermeasures are radioprotective agents that prevent and reduce IR injury or have therapeutic effects. Based on a good understanding of radiobiology, a number of protective agents have achieved positive results in early clinical trials. The present review grouped known radioprotective agents according to biochemical categories and potential clinical use, and reviewed radiation countermeasures, i.e., radioprotectors, radiation mitigators and radiotherapeutic agents, with an emphasis on their current status and research progress. The aim of the present review is to facilitate the selection and application of suitable radioprotectors for clinicians and researchers, to prevent or reduce IR injury.

show abstract

Section: Strategies To Reduce Radiation Injurymentioning

confidence: 99%

Radioprotective countermeasures for radiation injury (Review)

Liu

Liang

et al. 2023

Mol Med Rep

View full text Add to dashboard Cite

show abstract

Erythropoietin: Functions and Therapeutic Potential

Lykov

2024

Cell Tiss. Biol.

View full text Add to dashboard Cite

Erythropoietin: function and therapeutic potential

Лыков

2023

Sibirskij nauchnyj medicinskij zhurnal

Self Cite

View full text Add to dashboard Cite

Erythropoietin (EPO) exerts its eﬀect on erythroid lineage cells through interaction with the EPO receptor (EPOR), the so-called canonical pathway, and through a complex consisting of EPOR and a common cytokine receptor beta subunit (CD131) – a non-canonical pathway for non-hematopoietic cells of the human and animal body. EPO realizes its eﬀects through the launch of a signaling cascade, which begins with the phosphorylation of Janus kinase 2 (JAK2) and then with the involvement of phosphatidylinositol-3 kinase B (PI3K) or Ras-mitogen-activated protein kinase (MAPK) or signal transducers and transcription activators (STAT). EPO exhibits a direct cytoprotective eﬀect through increased CD131 expression and subsequent development of anti-apoptotic and anti-inﬂammatory eﬀects in target cells. In addition to its use in the treatment of anemia, EPO is increasingly being used in correction of inﬂammatory and degenerative processes, both in experimental and clinical studies. EPO promotes the engraftment of stem cells, diﬀerentiation of mesenchymal stem cells in the connective tissue direction, suppresses the inﬂammatory response and apoptosis of cells in the lesion. The article includes literature data concerning EPO and its clinical use in inﬂammatory and degenerative processes, based on data from eLibrary and the National Center for Biotechnological Information (NCBI) for the period 1998–2022.

show abstract

Therapeutic potential of a biomedical cellular product in rats with lower limb ischaemia

Cited by 3 publications

References 9 publications

Radioprotective countermeasures for radiation injury (Review)

Radioprotective countermeasures for radiation injury (Review)

Erythropoietin: Functions and Therapeutic Potential

Erythropoietin: function and therapeutic potential

Contact Info

Product

Resources

About