Therapeutic potential of 7-oxo-DHEA as an adjunctive host-directed therapy for pulmonary tuberculosis
María Belén Vecchione,
Jorge Barrios-Payán,
Dulce Mata-Espinosa
et al.
Abstract:Anti-tuberculous therapy successfully eradicates the infection, but it is long-lasting and impose the use of multiple drugs. Therefore, it is required to develop additional immunotherapy approaches to protect and manage human tuberculosis. In this study, we examined the properties of 7-oxo- dehydroepiandrosterone (7-oxo-DHEA), a DHEA-derivative hormone, through both in vitro and in vivo settings for M. tuberculosis (Mtb) infection. Firstly, we observed that 7-oxo-DHEA exhibited a bacteriostatic effect over Mtb… Show more
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