2010
DOI: 10.1111/j.1476-5381.2009.00489.x
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Therapeutic potential for novel drugs targeting the type 1 cholecystokinin receptor

Abstract: Cholecystokinin (CCK) is a physiologically important gastrointestinal and neuronal peptide hormone, with roles in stimulating gallbladder contraction, pancreatic secretion, gastrointestinal motility and satiety. CCK exerts its effects via interactions with two structurally related class I guanine nucleotide-binding protein (G protein)-coupled receptors (GPCRs), the CCK1 receptor and the CCK2 receptor. Here, we focus on the CCK1 receptor, with particular relevance to the broad spectrum of signalling initiated b… Show more

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Cited by 44 publications
(22 citation statements)
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“…Large body of data exists concerningseveral peptide and nonpeptidyl CCKAR modulators, and clinical potentials of these agents are under trial [37]. Our study defines two possible variants of GBC in this endemic belt.…”
Section: Discussionmentioning
confidence: 96%
“…Large body of data exists concerningseveral peptide and nonpeptidyl CCKAR modulators, and clinical potentials of these agents are under trial [37]. Our study defines two possible variants of GBC in this endemic belt.…”
Section: Discussionmentioning
confidence: 96%
“…2D shows that the CCK A71623 and pentagastrin mimicked the effect of CCK with regard to the stimulation of cholesterol absorption. Pentagastrin is ϳ968-fold selective for CCK2R over CCK1R (25), whereas A71623 is 1200-fold selective for CCK1R over CCK2R (26). The data in Fig.…”
Section: Cck Enhances Transcellular Cholesterol Transport In Caco-2 Cmentioning
confidence: 72%
“…CCK-CCK receptors play important roles in both gastrointestinal (GI) and central nervous system (CNS) functions (Cawston and Miller, 2010; Yu and Smagghe, 2014), due to the wide-spread distribution of both CCK1 and CCK2 receptors (Miller and Gao, 2008; Dockray and Burdyga, 2011). Of the group A GPCR receptors, CCK1 is unique in that it can be permanently activated by photodynamic oxidation (Cui and Kanno, 1997; An et al, 2003; Cui et al, 2012).…”
Section: Singlet Oxygen and Its Permanent Activation Of Cck1 Receptormentioning
confidence: 99%