Therapeutic potency of pharmacological adenosine receptor agonist/antagonist in angiogenesis, current status and perspectives

Bahreyni, Amirhossein; Khazaei, Majid; Rajabian, Majid; Ryzhikov, Mikhail; Rezayi, Majid; Hassanian, Seyed Mahdi

doi:10.1111/jphp.12844

Cited by 20 publications

(14 citation statements)

References 50 publications

(87 reference statements)

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“…By additional investigation of the A2a AR role in angiogenesis, Liu et al (2010) demonstrated that inactivation of A2a AR attenuates retinopathy angiogenesis which is oxygen-induced only. Normal retinal vascularization not involved, supporting the therapeutic potency of A2a AR antagonists for retinopathy (Sun et al, 2011;Bahreyni et al, 2018). This angiogenic ability of adenosine could explain the results of the present study manifested by increased vascularity, congestion of blood vessels and hemorrhage.…”

Section: Resultssupporting

confidence: 80%

Effects of Adenosine A2A Receptor Agonist on Histopathology of Some Oral Tissues in Rabbits

Al-Mashhadane

2020

ijrps

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Adenosine is a protective regulator that act endogenously to restore equilibrium of cellular energy in response to tissue trauma. It can perform such function of different systems in the body by activation of adenosine receptors. Study the effects of systemic administration of the adenosine on tongue and salivary glands tissues in the rabbit model. Thirty male rabbits of body weight of 1.5 ± 0.25kg were included in the study. In control group (15 animals), one ml of distilled water was injected intraperitoneally while in treatment group (15 animals) were injected by adenosine intraperitoneally at a dose of one mg/ml, All animals were sacrificed after 30 days. Serum samples were separated and used for analysis of adenosine deaminase (ADA)and glutathione(GSH). Tissue samples sections from tongue and salivary glands were stained with hematoxylin-eosin (H&E) and examined under a light microscope for histological changes by a blinded pathologist. Histological sections in treatment group showed congestion of blood vessels and infiltration of inflammatory cells with mild hemorrhage among acini of salivary glands. Increased level of adenosine in the body microenvironment may affect tongue and salivary glands tissues by modulating some processes including inflammation and blood vessels.

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Section: Resultssupporting

confidence: 80%

Effects of Adenosine A2A Receptor Agonist on Histopathology of Some Oral Tissues in Rabbits

Al-Mashhadane

2020

ijrps

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“…A 1 and A 2B receptors upregulate IL‐8, while A 2A receptors stimulate IL‐10 release. VEGF levels are increased by A 2A , A 2B , and A 3 receptor activities; HIF‐1α is elevated in response to A 3 receptor stimulation, and iNOS/endothelial NO synthase (eNOS) expression levels are upregulated, respectively, as consequence of A 2A and A 2B receptor activities (161). Interactions between murine A 2A and TLR‐2, ‐4, ‐7, and ‐9 in macrophages have been reported, upregulating VEGF and downregulating TNF‐α generating a so‐called angiogenic switch (162).…”

Section: Macrophages and Cancer Biologymentioning

confidence: 99%

Using Cytometry for Investigation of Purinergic Signaling in Tumor‐Associated Macrophages

et al. 2020

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Tumor-associated macrophages are widely recognized for their importance in guiding pro-tumoral or antitumoral responses. Mediating inflammation or immunosuppression, these cells support many key events in cancer progression: cell growth, chemotaxis, invasiveness, angiogenesis and cell death. The communication between cells in the tumor microenvironment strongly relies on the secretion and recognition of several molecules, including damage-associated molecular patterns (DAMPs), such as adenosine triphosphate (ATP). Extracellular ATP (eATP) and its degradation products act as signaling molecules and have extensively described roles in immune response and inflammation, as well as in cancer biology. These multiple functions highlight the purinergic system as a promising target to investigate the interplay between macrophages and cancer cells. Here, we reviewed purinergic signaling pathways connecting cancer cells and macrophages, a yet poorly investigated field. Finally, we present a new tool for the characterization of macrophage phenotype within the tumor. Image cytometry emerges as a cutting-edge tool, capable of providing a broad set of information on cell morphology, expression of specific markers, and its cellular or subcellular localization, preserving cell-cell interactions within the tumor section and providing high statistical strength in small-sized experiments. Thus, image cytometry allows deeper investigation of tumor heterogeneity and interactions between these cells.

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“…48,49 However, in some tumor cell lines, A1AR agonists inhibit tumor cell proliferation, 50,51 whereas in others, adenosine-induced A1 activation elicits a proapoptotic response by activation of caspases 3, 8, and 9. 35 The role of ARs has been investigated in various cancers [52][53][54] (Figure 1). Jafari et al 42 demonstrated that activation of A3AR by Cl-IB-MECA, an A3AR agonist, suppresses breast cancer stem cell proliferation by inhibition of extracellular signal-regulated kinases 1/2 (ERK1/2) and glioma-associated oncogene (GLI-1) pathways leading to cell cycle arrest and apoptosis in these cells.…”

Section: Adenosine Signaling In Cancer Pathologymentioning

confidence: 99%

“…The role of ARs has been investigated in various cancers (Figure ). Jafari et al demonstrated that activation of A3AR by Cl‐IB‐MECA, an A3AR agonist, suppresses breast cancer stem cell proliferation by inhibition of extracellular signal‐regulated kinases 1/2 (ERK1/2) and glioma‐associated oncogene (GLI‐1) pathways leading to cell cycle arrest and apoptosis in these cells.…”

Section: Adenosine Signaling In Cancer Pathologymentioning

confidence: 99%

Role of adenosine signaling in the pathogenesis of head and neck cancer

Khayami

Toroghian

Bahreyni

et al. 2018

J of Cellular Biochemistry

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The concentrations of adenosine may increase under ischemic conditions in the tumor microenvironment, and then it enters the systemic circulation. Adenosine controls cancer progression and responses to therapy by regulating angiogenesis, cell survival, apoptosis, cell proliferation, and metastases in tumors. Hence, adenosine metabolism, adenosine-generating enzymes, and adenosine signaling are potentially novel therapeutic targets in a wide range of pathological conditions, including cerebral and cardiac ischemic diseases, inflammatory disorders, immunomodulatory disorders, and, of special interest in this review, cancer. This review summarizes the role of adenosine in the pathogenesis of head and neck cancer for a better understanding of how this may be applied to treating this type of cancer.

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Therapeutic potency of pharmacological adenosine receptor agonist/antagonist in angiogenesis, current status and perspectives

Cited by 20 publications

References 50 publications

Effects of Adenosine A2A Receptor Agonist on Histopathology of Some Oral Tissues in Rabbits

Effects of Adenosine A2A Receptor Agonist on Histopathology of Some Oral Tissues in Rabbits

Using Cytometry for Investigation of Purinergic Signaling in Tumor‐Associated Macrophages

Role of adenosine signaling in the pathogenesis of head and neck cancer

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