Therapeutic polymeric nanomedicine: GSH-responsive release promotes drug release for cancer synergistic chemotherapy

Shen, Jie; Wang, Qiwen; Fang, Jie; Shen, Wang-Xing; Wu, Dan; Tang, Guping; Yang, Jie

doi:10.1039/c9ra07051f

Cited by 12 publications

(5 citation statements)

References 50 publications

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“…Glutathiones is a natural compound that protects cells from oxidative damage and from the toxicity of xenobiotic electrophiles but may also enhance the intracellular reduction of Pt(IV) prodrugs into the corresponding Pt(II) active form. GSH concentrations in intracellular and extracellular environments have been found to range between 2–10 mM and 2–20 μM, respectively [ 48 , 49 , 50 ]. However, in our case, the more relevant value was that of GSH levels in the brain, reported to be 1–2 mM in normal conditions [ 51 ].…”

Section: Resultsmentioning

confidence: 99%

Intranasal Administration of Catechol-Based Pt(IV) Coordination Polymer Nanoparticles for Glioblastoma Therapy

et al. 2022

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Cisplatin has been described as a potent anticancer agent for decades. However, in the case of glioblastomas, it is only considered a rescue treatment applied after the failure of second-line treatments. Herein, based on the versatility offered by coordination chemistry, we engineered nanoparticles by reaction of a platinum (IV) prodrug and iron metal ions showing in vitro dual pH- and redox-sensitivity, controlled release and comparable cytotoxicity to cisplatin against HeLa and GL261 cells. In vivo intranasal administration in orthotopic preclinical GL261 glioblastoma tumor-bearing mice demonstrated increased accumulation of platinum in tumors, leading in some cases to complete cure and prolonged survival of the tested cohort. This was corroborated by a magnetic resonance imaging follow-up, thus opening new opportunities for intranasal glioblastoma therapies while minimizing side effects. The findings derived from this research showed the potentiality of this approach as a novel therapy for glioblastoma treatment.

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Section: Resultsmentioning

confidence: 99%

Intranasal Administration of Catechol-Based Pt(IV) Coordination Polymer Nanoparticles for Glioblastoma Therapy

et al. 2022

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“…For instance, Shen et al attached the disulfide-containing cleavable prodrug monomer, camptothecin (CPT), onto the methoxy poly(ethylene glycol) (mPEG)-based polymer chain by RAFT living polymerization and developed an amphiphilic copolymer. 147 Apart from the CPT, doxorubicin (DOX) was encapsulated via hydrophobic and π-π stacking interactions. In their work, the co-release of both the anticancer drugs are well controlled and demonstrated synergetic effect with enhanced anticancer efficacy, as illustrated in Figure 18.…”

Section: Disulfide Linkagementioning

confidence: 99%

Stimuli-responsive structure–property switchable polymer materials

Png

Wang

Yeo

et al. 2023

Mol. Syst. Des. Eng.

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“…Високі рівні глутатіону [26] спостерігаються при багатьох пухлинах, тому, враховуючи його роль в онкогенезі та запальних процесах, створено прямі підходи в терапії, направлені на регулювання синтезу GSH, який може зумовити фероптоз клітин (загибелі клітин, опосередковані перокисним окисненням ліпідів клітинних мембран) та непрямі методи, націлені на запальну реакцію або мікрооточення пухлини та імунотерапію. У процесі лікування онкохворих рівні GSH можуть бути індикатором успіху терапії [4,49,57]. Ліки на основі Lбутионін-сульфоксиміну інгібують синтез глутатіону, блокуючи активність γ-глутамілцистеїн синтетази.…”

Section: результати обговоренняunclassified

Glutathione: synthesis, mechanism of action, antioxidant and detoxifying role

Gerush,

Grigoryeva,

Ferenchuk

2023

Rep. of Vinnytsia Nation. Med. Univ.

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Annotation. Under the conditions of entry of toxic substances into the body and activation of redox processes, compounds of natural origin with antioxidant properties are widely used to correct metabolic disorders. The purpose of the work is to conduct an analysis and systematization of basic and modern scientific sources of literature on the role of the glutathione system in the development of pathologies. For the scientific review, data from the scientometric databases PubMed, ScienceDirect, Web of Science, Google Scholar, etc. were used, and the analysis of scientific textbooks and monographs was carried out. Among water-soluble antioxidants, low- and high-molecular compounds containing SH-groups are popular in medicine, mono-, di- and tricarboxylic acids and other anions. Glutathione, a thiol-containing tripeptide, is the main endogenous non-enzymatic antioxidant that exerts cytoprotective and detoxifying properties. Various epithelial cells – enterocytes, endotheliocytes, alveolar cells of the lungs, epithelium of the proximal renal tubules, absorb and use glutathione most intensively, in particular, taken orally, so the idea of using glutathione in diseases of organs that actively participate in detoxification processes: kidneys, liver, lungs, as well as under the conditions of systemic diseases accompanied by endothelial dysfunction and oxidative stress – diabetes, atherosclerosis, nephropathy. Under physiological conditions, the body maintains a dynamic balance between the content of oxidants, which stimulate the processes of free radical oxidation of biomolecules, and the activity of antioxidant systems. But under the conditions of damage to any link of the living system, increased formation of reactive oxygen species (ROS) and inhibition of antioxidant systems contributes to the activation of free radical oxidation processes, the intensity of which depends on the concentration of oxygen in the tissues and on the enzymatic and non-enzymatic systems of antioxidant protection, which prevents the destruction of cells by active forms of oxygen.

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Therapeutic polymeric nanomedicine: GSH-responsive release promotes drug release for cancer synergistic chemotherapy

Abstract: In the GSH-responsive doxorubicin loading camptothecin prodrug nanomedicine, easy modulation of the dose ratio and controlled co-release were achieved, and the synergistic effect was significantly improved.

Cited by 12 publications

References 50 publications

Intranasal Administration of Catechol-Based Pt(IV) Coordination Polymer Nanoparticles for Glioblastoma Therapy

Intranasal Administration of Catechol-Based Pt(IV) Coordination Polymer Nanoparticles for Glioblastoma Therapy

Stimuli-responsive structure–property switchable polymer materials

Glutathione: synthesis, mechanism of action, antioxidant and detoxifying role

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