Therapeutic Plasma‐albumin Exchange for Hyperlipidemia Induced Acute Pancreatitis

Abstract

They conclude that in an in vitro gastrointestinal model simulating infant conditions, the protein quality is not different between the goat milk-based infant formula, cow milk-based infant formula, and human milk, but the kinetics of protein digestion of the goat milk-based infant formula is more comparable to that of human milk than that of the cow milk-based infant formula.Food and Agriculture Organization (FAO) (2) recommends to evaluate the protein quality based on true protein digestibility in the small intestine and the bioavailability of individual indispensable amino acid with the Digestible Indispensable Amino Acid Score.Nevertheless, we retain that adding the evaluation of proteomic profile can be a useful evaluation tool to understand the different kinetics underlined by the authors.A recent proteomic analysis of extensively hydrolysed milk formulas, using a nano-liquid chromatography-mass spectrometry analyses method, revealed that also the peptide profiles of commercially available hydrolyzed milk protein formulations provides a descriptive and distinct signature (3).The proteomic analysis and the use of dynamic gastrointestinal models could succeed in explaining the real pathogenesis of many conditions of impaired digestion, wrongly classified as nonimmunoglobulin E allergies mediated to cow's milk proteins.Further research is necessary to evaluate whether dynamic gastrointestinal models are the best possible approach to explore food and epithelium interaction.

Acute pancreatitis due to severe hypertriglyceridemia in the COVID-19 era: The role of therapeutic plasma exchange

“…The importance of adding FFP as a partial replacement fluid has to be highlighted as it enhances TG removal beyond the expected results (≥90% in 6 out of 11 HTG-AP episodes), while keeping with the putative addition of plasma lipoprotein-lipase activity [ 14 ].…”