Therapeutic Peptides and Proteins: Stabilization Challenges and Biomedical Applications by Means of Nanodelivery Systems
Elisa Berselli,
Carlotta Coccolini,
Giovanni Tosi
et al.
Abstract:The delivery of peptides and proteins usually faces formulation development challenges attributed to the difficulties encountered in their stabilization. Nanoparticles offer an alternative to improve the physicochemical stability of such biomacromolecules, while increasing their bioavailability by overcoming biological absorption barriers. With this review, we aim to discuss the stability problems of proteins and peptides that have driven the scientific community to find in nanotechnology a valid alternative f… Show more
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