Therapeutic Paradigm Underscoring Glucosinolate Sulforaphane in Chemo- and Radiosensitization of Cancer: Preclinical and Clinical Perspective

Banerjee, Sanjeev; Paruthy, Shivani B.; Mérillon, Jean‐Michel; Ramawat, K. G.

doi:10.1007/978-3-319-25462-3_19

Cited by 2 publications

(2 citation statements)

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“…We have found that the research of the last years on GSL extracts was mainly focused on broccoli extracts and SFN (the main GSL-metabolite from broccoli). In this regard, several preclinical studies have been performed with the intention to reveal the mechanisms behind the protection against the development and/or progression of different diseases, particularly, cancer ( 78 ). The main putative protective mechanisms included the induction of endogenous antioxidants defense, detoxification enzymes, and the activation of cytoprotective genes ( 70 , 79 ).…”

Section: Discussionmentioning

confidence: 99%

An Overview of Registered Clinical Trials on Glucosinolates and Human Health: The Current Situation

et al. 2021

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Epidemiological studies suggest a potential role of glucosinolates (GSLs) and isothiocyanates on human health. However, evidence from intervention studies, due to heterogeneity in features of study design, duration, participants, food or food components administered, and outcomes analyzed, is still insufficient. The current review aims to provide an overview of the trials on GSLs and GSL-rich foods registered over the last 20 years with the intention to summarize the main topics and results, but also the existing gaps that still need to be covered. Studies were collected by using ClinicalTrials.gov and the International Standard Randomized Controlled Trial Number (ISRCTN) registry. A total of 87 registered trials were identified with which most of them were performed by using extracts or pure compounds (n = 60) while few were conducted with GSL-rich foods (n = 27). In detail, sulforaphane was the most investigated compound, while broccoli was the most frequent food tested in the trials. The majority of the studies assessed the health effects of GSLs focusing on outcomes related to cancer and cognitive function, even if the current findings are not univocal. Emerging topics also included the study of GSLs and gut microbiota interaction and impact on skin health. Further attention was also drawn to the bioavailability of GSLs and/or derivatives from foods, extracts, and single compounds by also considering the contribution of the different genetic polymorphisms. In conclusion, although considerable efforts have been made to study GSLs and GSL-rich foods, further studies are necessary to provide evidence-based research and to corroborate the findings obtained. The interindividual response due to genetic polymorphisms should be further investigated in order to explore the contribution to the overall beneficial effect.

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Section: Discussionmentioning

confidence: 99%

An Overview of Registered Clinical Trials on Glucosinolates and Human Health: The Current Situation

et al. 2021

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“…GLSs impart specific pungency and flavors to Brassicaceae vegetables such as mustard and cabbage (Fahey et al, 2001; Halkier, 2016; Possenti et al, 2017). Moreover, a few GLS compounds such as glucoraphanin (4-methylsulfinyl- n -butyl glucosinolate) are known to produce health-promoting chemicals with diverse bioactivities (Traka, 2016; Banerjee and Paruthy, 2017). Very recently, the enormous body of research activities on GLS has been compiled as two books entitled Glucosinolates with few overlaps (Kopriva, 2016; Mérillon and Ramawat, 2017).…”

Section: Introductionmentioning

confidence: 99%

Atypical Myrosinase as a Mediator of Glucosinolate Functions in Plants

Sugiyama

Hirai

2019

Front. Plant Sci.

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Glucosinolates (GLSs) are a well-known class of specialized plant metabolites, distributed mostly in the order Brassicales. A vast research field in basic and applied sciences has grown up around GLSs owing to their presence in important agricultural crops and the model plant Arabidopsis thaliana , and their broad range of bioactivities beneficial to human health. The major purpose of GLSs in plants has been considered their function as a chemical defense against predators. GLSs are physically separated from a specialized class of beta-thioglucosidases called myrosinases, at the tissue level or at the single-cell level. They are brought together as a consequence of tissue damage, primarily triggered by herbivores, and their interaction results in the release of toxic volatile chemicals including isothiocyanates. In addition, recent studies have suggested that plants may adopt other strategies independent of tissue disruption for initiating GLS breakdown to cope with certain biotic/abiotic stresses. This hypothesis has been further supported by the discovery of an atypical class of GLS-hydrolyzing enzymes possessing features that are distinct from those of the classical myrosinases. Nevertheless, there is only little information on the physiological importance of atypical myrosinases. In this review, we focus on the broad diversity of the beta-glucosidase subclasses containing known atypical myrosinases in A. thaliana to discuss the hypothesis that numerous members of these subclasses can hydrolyze GLSs to regulate their diverse functions in plants. Also, the increasingly broadening functional repertoires of known atypical/classical myrosinases are described with reference to recent findings. Assessment of independent insights gained from A. thaliana with respect to (1) the phenotype of mutants lacking genes in the GLS metabolic/breakdown pathways, (2) fluctuation in GLS contents/metabolism under specific conditions, and (3) the response of plants to exogenous GLSs or their hydrolytic products, will enable us to reconsider the physiological importance of GLS breakdown in particular situations, which is likely to be regulated by specific beta-glucosidases.

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Therapeutic Paradigm Underscoring Glucosinolate Sulforaphane in Chemo- and Radiosensitization of Cancer: Preclinical and Clinical Perspective

Cited by 2 publications

References 145 publications

An Overview of Registered Clinical Trials on Glucosinolates and Human Health: The Current Situation

An Overview of Registered Clinical Trials on Glucosinolates and Human Health: The Current Situation

Atypical Myrosinase as a Mediator of Glucosinolate Functions in Plants

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