Therapeutic outcomes of transplantation of amniotic fluid-derived stem cells in experimental ischemic stroke

Tajiri, Naoki; Acosta, Sandra; Portillo-Gonzales, Gabriel S.; Aguirre, Daniela; Reyes, Stephanny; Lozano, Diego; Pabon, Mibel; Peña, Ike dela; Ji, Xunming; Yasuhara, Takao; Date, Isao; Solomita, Marianna A.; Antonucci, Ivana; Stuppia, Liborio; Kaneko, Yuji; Borlongan, Cesar V.

doi:10.3389/fncel.2014.00227

Cited by 23 publications

(17 citation statements)

References 88 publications

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“…Other molecular pathways for axonal sprouting, either induced in peri-infarct neurons or contralateral neurons [98], indicate promising targets for neural repair such as ephrin-A5, GDF10, and the use of the small molecule inosine [36,69,98,113]. Cell therapies appear to stimulate local axonal sprouting by tissue immunohistochemical staining [117][118][119], and in some cases by more detailed direct demonstration of axonal connections [120]. These also represent a candidate neural repair approach.…”

Section: Potential Neural Repair Therapiesmentioning

confidence: 99%

The 3 Rs of Stroke Biology: Radial, Relayed, and Regenerative

Carmichael

2016

Neurotherapeutics

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Stroke not only causes initial cell death, but also a limited process of repair and recovery. As an overall biological process, stroke has been most often considered from the perspective of early phases of ischemia, how these inter-relate and lead to expansion of the infarct. However, just as the biology of later stages of stroke becomes better understood, the clinical realities of stroke indicate that it is now more a chronic disease than an acute killer. As an overall biological process, it is now more important to understand how early cell death leads to the later, limited recovery so as develop an integrative view of acute to chronic stroke. This progression from death to repair involves sequential stages of primary cell death, secondary injury events, reactive tissue progenitor responses, and formation of new neuronal circuits. This progression is radial: from the tissue that suffers the infarct secondary injury signals, including free radicals and inflammatory cytokines, radiate out from the stroke core to trigger later regenerative events. Injury and repair processes occur not just in the local stroke site, but are also triggered in the connected networks of neurons that had existed in the stroke center: damage signals are relayed throughout a brain network. From these relayed, distributed damage signals, reactive astrocytosis, inflammatory processes, and the formation of new connections occur in distant brain areas. In short, emerging data in stroke cell death studies and the development of the field of stroke neural repair now indicate a continuum in time and in space of progressive events that can be considered as the 3 Rs of stroke biology: radial, relayed, and regenerative.

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Section: Potential Neural Repair Therapiesmentioning

confidence: 99%

The 3 Rs of Stroke Biology: Radial, Relayed, and Regenerative

Carmichael

2016

Neurotherapeutics

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“…Acosta and colleagues have provided preclinical evidence of safety and efficacy of stem cell therapy in traumatic brain injury [26,27] and in stroke [28,29]. In this article, they highlight the bioethical issues that have accompanied this cell therapy over the last two decades and raised public concern, including safety measures, commercialization, and confidentiality of donors.…”

Section: Bridging the Gap Between The Public And Scientific Communitymentioning

confidence: 99%

An update on stem cell therapy for neurological disorders: cell death pathways as therapeutic targets

et al. 2017

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Here, we compiled ten papers detailing recent strides in the field of stem cell therapy, which address critical issues relevant to pursuing this experimental treatment for clinical applications in brain disorders. Topics include efficacy, safety, and mechanism of action underlying cell therapy, emerging technologies and combination pharmacotherapies with cell transplantation directed at improving the functional outcomes, and evaluation of key translational components of advancing novel therapeutics to the clinic, including the need for vis-à-vis comparisons with the gold standard of treatment post-injury (i.e., physical rehabilitation). A bioethics paper is also incorporated here to further appreciate the current status of cell therapy in the community setting. The overall goal of this special volume is to provoke a meaningful assessment of the lessons we have learned in recent years and to use such knowledge to carefully translate safe and effective applications of cell therapy, and its mechanism of action for the treatment of neurological disorders.

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“…been used to treat stroke in rat models, and it was found that both motor and cognitive deficits were reduced after the transplantation. Furthermore, the cell proliferation in the subventrical zone (SVZ) was increased (Tajiri et al, 2014). However, amniotic fluid-derive cells are a heterogeneous cells population with diverse phenotypes.…”

Section: Instructionmentioning

confidence: 99%