Therapeutic nanoparticles penetrate leaves and deliver nutrients to agricultural crops

Karny, Avishai; Zinger, Assaf; Kajal, Ashima; Shainsky‐Roitman, Janna; Schroeder, Avi

doi:10.1038/s41598-018-25197-y

Cited by 162 publications

(107 citation statements)

References 34 publications

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“…They can be applied to the soil 15 or into the plant; 2 , 20 upon foliar application, some NCs are able to penetrate the leaves and are translocated throughout the plant. 21 , 22 Furthermore, targeted delivery to chloroplasts is known. 23 Some studies report the utilization of NCs to overcome nutrient deficiencies, 24 , 25 for growth regulation 26 and for the sustained release of herbicides, 27 nematocides, 28 fungicides, 29 and insecticides.…”

Section: Introductionmentioning

confidence: 99%

Bio-Based Lignin Nanocarriers Loaded with Fungicides as a Versatile Platform for Drug Delivery in Plants

et al. 2020

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Lignin-based nano- and microcarriers are a promising biodegradable drug delivery platform inside of plants. Many wood-decaying fungi are capable of degrading the wood component lignin by segregated lignases. These fungi are responsible for severe financial damage in agriculture, and many of these plant diseases cannot be treated today. However, enzymatic degradation is also an attractive handle to achieve a controlled release of drugs from artificial lignin vehicles. Herein, chemically cross-linked lignin nanocarriers (NCs) were prepared by aza-Michael addition in miniemulsion, followed by solvent evaporation. The cross-linking of lignin was achieved with the bio-based amines (spermine and spermidine). Several fungicides—namely, azoxystrobin, pyraclostrobin, tebuconazole, and boscalid—were encapsulated in situ during the miniemulsion polymerization, demonstrating the versatility of the method. Lignin NCs with diameters of 200–300 nm (determined by dynamic light scattering) were obtained, with high encapsulation efficiencies (70–99%, depending on the drug solubility). Lignin NCs successfully inhibited the growth of Phaeomoniella chlamydospora and Phaeoacremonium minimum , which are lignase-producing fungi associated with the worldwide occurring fungal grapevine trunk disease Esca. In planta studies proved their efficiency for at least 4 years after a single injection into Vitis vinifera (“Portugieser”) plants on a test vineyard in Germany. The lignin NCs are of high interest as biodegradable delivery vehicles to be applied by trunk injection against the devastating fungal disease Esca but might also be promising against other fungal plant diseases.

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Section: Introductionmentioning

confidence: 99%

Bio-Based Lignin Nanocarriers Loaded with Fungicides as a Versatile Platform for Drug Delivery in Plants

et al. 2020

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“…Nanoparticles have been vastly explored for biomedical applications such as; biocides agents (Hemeg, 2017), gene therapy (Liu and Zhang, 2011), cellular imaging (Hemmerich and von Mikecz, 2013) and molecular recognition and sensing (Yan and Chen, 2019). Useful agricultural applications have been reported in the literature as well, such as; the use of nanoparticles for enhancing plant growth and yield (Karny et al, 2018;Rastogi et al, 2019;Sanzari et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Biological interaction levels of zinc oxide nanoparticles; lettuce seeds as case study

Rawashdeh

Harb

AlHasan

2020

Heliyon

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Background: Seed germination is a critical stage in plant life, and recent practices use nanomaterials for the improvement of plant seed germination indices. This study was conducted to assess the effect of laboratory prepared zinc oxide nanoparticles on the physiological and biochemical changes of lettuce seeds. Methods: Lettuce seeds were soaked in a suspension of moderately polydisperse zinc oxide nanoparticles at two different concentrations (25 ppm or 50 ppm) and shaken for 3 h at 25 C. Seeds treatment was followed subsequently by two to three days drying at ambient conditions. Treated seeds were stored for 3-4 weeks, at ambient conditions and then tested for germination in petri dishes. Germination was observed on daily basis and seedling length was measured. After imbibition and before the start of the visible germination, seeds were examined for topography and surface analysis using the scanning electron microscope and zinc uptake was measured by using the atomic absorption spectrometry and the energy dispersive X-ray. The pattern of mobilization of biomolecules was analyzed to detect any differences among different seed groups. Results: There was no loss of viability for the nanoparticles treated seeds. Indeed their germination was enhanced and their biomass increased. The activated performance of the nanoparticles imbibed seeds has been found to be correlated with an increased level of Zn inside lettuce seeds. The recorded measurements show a significant enhancement of seedling length. Interaction of zinc oxide nanoparticles with lettuce seeds mediates a variation in the biochemical processes. Changes detected in treated seeds were as following: reduced levels of the total carbohydrates (including simple saccharides and polysaccharides), higher capacity of protein synthesis, an elevated level of starch as well as an increased activity of antioxidant enzymes. Discussion and conclusion: Lettuce seeds primed with ZnO nanoparticles were found not only to maintain seed viability but even to exhibit a detectable level of germination enhancement compared to the control seeds. Overall, the promoted response of lettuce seeds during early stages of seed growth is encouraging for the application of ZnO NPs for seed priming for better germination indices.

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“…The NP fertilizers can facilitate tunable delivery of the required nutrients to the plants. Therefore, NP fertilizers are seen as highly promising candidates for enhanced production of agricultural and bioenergy crops to meet the growing food and energy demands of the world population [5,[7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Increased Plant Growth with Hematite Nanoparticle Fertilizer Drop and Determining Nanoparticle Uptake in Plants Using Multimodal Approach

Boutchuen

Zimmerman

Aich

et al. 2019

Journal of Nanomaterials

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There is an emerging scientific interest in the use of nanoparticle fertilizers for enhanced agricultural and bioenergy crop production to meet the growing food and energy demands of the world. The objective of designing the nanoparticle fertilizers is to effectively deliver the required nutrients for the plants without adding large quantities of fertilizer to the environment. However, most reports on nanoparticle fertilizers so far, involved the addition of nanoparticles to the hydroponic system or the soil. In this study, we report a new modified seed presoak strategy using a drop of Fe-enriching hematite nanoparticle dispersion to enhance plant growth and production in four different legume species, i.e., chickpea, green gram, black bean, and red bean. The hematite nanoparticle fertilizer drop promoted a 230-830% increase in plant growth with green gram showing the highest increase, based on our prolonged and statistically reliable growth studies. In general, we observed an increase in the survival span of plants, a twofold increase in fruit production per plant, nearly two times faster fruit production, and healthy secondgeneration plants with the nanoparticle treatment; however, there were slight species-specific variations. We used a novel multimodal material characterization approach combining three techniques, hyperspectral imaging, Fourier transform infrared spectroscopy (FTIR), and inductively coupled plasma optical emission spectroscopy (ICP-OES), to evaluate the internalization and transport of the nanoparticle fertilizer within the plants. Our results indicated that the hematite nanoparticles were transported through the roots and stems and were localized in the leaves after 10 days of growth in pots of soil. Therefore, the modified seed presoaking method using a drop of hematite nanoparticle will be highly attractive in enhancing plant growth and health, while minimizing environmental impacts.

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Therapeutic nanoparticles penetrate leaves and deliver nutrients to agricultural crops

Cited by 162 publications

References 34 publications

Bio-Based Lignin Nanocarriers Loaded with Fungicides as a Versatile Platform for Drug Delivery in Plants

Bio-Based Lignin Nanocarriers Loaded with Fungicides as a Versatile Platform for Drug Delivery in Plants

Biological interaction levels of zinc oxide nanoparticles; lettuce seeds as case study

Increased Plant Growth with Hematite Nanoparticle Fertilizer Drop and Determining Nanoparticle Uptake in Plants Using Multimodal Approach

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