Nanozymes (NSEs), which are efficient nanomaterials with enzyme-like appearances, have proved themselves highly-stable compared to the natural enzymes. They are also organized with the exclusive fundamental properties of nanomaterials such as luminescence and magnetism. Thus, in the biomedical field, their expansions demonstrate that their catalytic movements have opened up new applications as well as opportunities. Nanozymes are excellent in the informal mass production as well as long term storage. They are also helpful in the field of biomedical technology for the treatment of many diseases. They may incorporate various therapeutically effects in the anti-inflammatory, cytoprotecting, brain diseases and dental biofilms as well as in cardiovascular diseases. They have also performed as impartial therapeutics with other therapeutic approaches to increase antitumor effects. This chapter describes their fascinating applications in therapeutics the associated mechanism.